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公开(公告)号:US09995683B2
公开(公告)日:2018-06-12
申请号:US14308477
申请日:2014-06-18
Applicant: Industrial Technology Research Institute
Inventor: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
IPC: G01N21/00 , G01N21/64 , B82Y15/00 , G01N21/77 , G01N33/543
CPC classification number: G01N21/6486 , B82Y15/00 , G01N21/645 , G01N21/648 , G01N21/7703 , G01N33/54373 , G01N2021/6482 , G01N2021/6484 , G01N2201/088 , Y10S977/954 , Y10S977/957 , Y10S977/958 , Y10T436/143333 , Y10T436/145555
Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
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公开(公告)号:US09777321B2
公开(公告)日:2017-10-03
申请号:US15260773
申请日:2016-09-09
Applicant: Industrial Technology Research Institute
Inventor: Chung-Fan Chiou , Ying-Chih Pu , Chao-Chi Pan , Chih-Tsung Shih , Ming-Chia Li , Chein-Shiu Kuo , Hung-Chi Chien , Chang-Sheng Chu
CPC classification number: C12Q1/6869 , G01N21/6428 , G01N21/6452 , G01N21/6454 , G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2201/08 , G01N2201/12 , C12Q2563/155 , C12Q2561/113
Abstract: Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.
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公开(公告)号:US20140367589A1
公开(公告)日:2014-12-18
申请号:US14308477
申请日:2014-06-18
Applicant: Industrial Technology Research Institute
Inventor: Chung-Fan Chiou , Rung-Ywan Tsai , Yu-Tang Li , Chih-Tsung Shih , Ming-Chia Li , Chang-Sheng Chu , Shuang-Chao Chung , Jung-Po Chen , Ying-Chih Pu
IPC: G01N21/64
CPC classification number: G01N21/6486 , B82Y15/00 , G01N21/645 , G01N21/648 , G01N21/7703 , G01N33/54373 , G01N2021/6482 , G01N2021/6484 , G01N2201/088 , Y10S977/954 , Y10S977/957 , Y10S977/958 , Y10T436/143333 , Y10T436/145555
Abstract: An apparatus for detecting an object capable of emitting light. The apparatus includes a light source and a waveguide. The waveguide includes a core layer and a first cladding layer. At least one nanowell is formed in at least the first cladding layer. The apparatus further includes a light detector. The light detector can detect a light emitted from a single molecule object contained in the at least one nanowell.
Abstract translation: 一种用于检测能够发光的物体的装置。 该装置包括光源和波导。 波导包括芯层和第一覆层。 在至少第一包层中形成至少一个纳米线。 该装置还包括光检测器。 光检测器可以检测从包含在至少一个纳米管中的单个分子对象发射的光。
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公开(公告)号:US20170009286A1
公开(公告)日:2017-01-12
申请号:US15260773
申请日:2016-09-09
Applicant: Industrial Technology Research Institute
Inventor: Chung-Fan Chiou , Ying-Chih Pu , Chao-Chi Pan , Chih-Tsung Shih , Ming-Chia Li , Chein-Shiu Kuo , Hung-Chi Chien , Chang-Sheng Chu
CPC classification number: C12Q1/6869 , G01N21/6428 , G01N21/6452 , G01N21/6454 , G01N21/648 , G01N21/7703 , G01N2021/6439 , G01N2201/08 , G01N2201/12 , C12Q2563/155 , C12Q2561/113
Abstract: Embodiments encompass a single-molecule detection system and methods of using the detection system to detect an object. Further, embodiments encompass a detection system comprising a movable light coupler, a waveguide, and a light detector. Embodiments further encompass methods of single-molecule detection, including methods of single-molecule nucleic acid sequencing.
Abstract translation: 实施例包括单分子检测系统和使用检测系统检测物体的方法。 此外,实施例包括包括可移动光耦合器,波导和光检测器的检测系统。 实施方案进一步包括单分子检测的方法,包括单分子核酸测序的方法。
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