公开(公告)号：US20030113379A1

公开(公告)日：2003-06-19

申请号：US10219674

申请日：2002-08-16

Applicant: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

Inventor： Da-Young Chen ,  Huey-Min Lai ,  Yuan-Han Chen ,  Rung-Jiun Gau

IPC: A61K031/66 ,  A61K009/14

CPC classification number: A61L27/48 ,  A61K31/00 ,  A61L27/58

Abstract: A biodegradable composite matrix for enhancing angiogenesis. The matrix includes a biodegradable material and a phospholipid distributed in the biodegradable material as a liposome or micelle. Derivatives of phospholipid have chemo-attraction properties and thus induce the transfer of endothelial cells into the system through tropism-inductive mechanism. The biodegradable composite matrix induces an intracellular signal cascade that is different from cascade induced by a growth factor, and can coordinate with the growth factor-induced cascade to enhance angiogenesis. The present invention also includes the method for producing the biodegradable composite matrix.

Abstract translation: 用于增强血管发生的可生物降解的复合基质。 该基质包括分解在生物可降解材料中的可生物降解材料和磷脂作为脂质体或胶束。 磷脂的衍生物具有化学吸引性，因此通过向性诱导机制诱导内皮细胞向系统的转移。 可生物降解的复合基质诱导与生长因子诱导的级联不同的细胞内信号级联，并且可以与生长因子诱导的级联配合以增强血管发生。 本发明还包括生物可降解复合基质的制造方法。

公开(公告)号：US20040013733A1

公开(公告)日：2004-01-22

申请号：US10330085

申请日：2002-12-30

Applicant: Industrial Technology Research Institute

Inventor： Yuan-Han Chen ,  Ming-Hsi Yeh ,  Huey-Min Lai

IPC: A61K038/39 ,  A61K031/737 ,  A61K031/716 ,  A61K009/14

CPC classification number: A61K9/0024 ,  A61K47/36 ,  A61L27/26 ,  A61L27/52 ,  C08L89/06 ,  C08L5/08

Abstract: The present invention relates to a biodegradable thermal-sensitive gel system, which comprises at least one polysaccharide solution, at least one electrolytic salt, and at least one buffer solution for adjusting pH. A natural protein as well as a cross-linking agent can be added to the gel system optionally. Said gel system is liquid at room temperature (25null C.) and solidifies at or above 37null C. The present invention also relates to a process for preparing said gel system, and a use for drug releasing carrier.

Abstract translation: 本发明涉及一种可生物降解的热敏凝胶体系，其包含至少一种多糖溶液，至少一种电解质盐和至少一种用于调节pH的缓冲溶液。 天然蛋白质以及交联剂可以任选地添加到凝胶体系中。 所述凝胶体系在室温（25℃）下为液体，并在37℃或更高温度下固化。本发明还涉及制备所述凝胶体系的方法和用于药物释放载体的用途。