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11 条记录 (耗时 0.04 秒)

    Benzothiepine ileal bile acid transport inhibitors
    3.
    发明授权
    Benzothiepine ileal bile acid transport inhibitors 有权
    苯妥英回肠胆酸运输抑制剂

    公开(公告)号：US07226943B2

    公开(公告)日：2007-06-05

    申请号：US10489010

    申请日：2002-09-05

    申请人： Ingemar Starke ,  Mikael Ulf Johan Dahlstrom ,  David Blomberg

    发明人： Ingemar Starke ,  Mikael Ulf Johan Dahlstrom ,  David Blomberg

    IPC分类号： A61K31/38 ,  C07D337/12

    CPC分类号： C07D409/12 ,  C07D337/08

    摘要： The present invention relates to compounds of formula (I) wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described

    摘要翻译： 本发明涉及式（I）化合物，其中可变基团如本文所定义; 药学上可接受的盐，溶剂合物，这些盐的溶剂合物和前药，以及它们作为回肠胆汁转运（IBAT）抑制剂用于治疗高脂血症的用途。 还描述了其制备方法和含有它们的药物组合物

    Benzothiazepine derivatives for the treatment of hyperlipidemia
    4.
    发明授权
    Benzothiazepine derivatives for the treatment of hyperlipidemia 有权
    苯并硫氮因衍生物用于治疗高脂血症

    公开(公告)号：US07125864B2

    公开(公告)日：2006-10-24

    申请号：US10489009

    申请日：2002-09-05

    申请人： Ingemar Starke ,  Mikael Ulf Johan Dahlstrom ,  David Blomberg

    发明人： Ingemar Starke ,  Mikael Ulf Johan Dahlstrom ,  David Blomberg

    IPC分类号： C07D281/10 ,  A61P31/554 ,  A61K3/06

    CPC分类号： C07D281/10

    摘要： The present invention relates to compounds of formula (I): wherein variable groups are as defined within; pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidemia. Processes for their manufacture and pharmaceutical compositions containing them are also described

    摘要翻译： 本发明涉及式（I）化合物：其中可变基团如本文所定义; 药学上可接受的盐，溶剂合物，这些盐的溶剂合物和前药，以及它们作为回肠胆汁酸转运（IBAT）抑制剂用于治疗高脂血症的用途。 还描述了其制备方法和含有它们的药物组合物

    Benzothiazepine derivatives
    8.
    发明授权
    Benzothiazepine derivatives 有权
    苯并硫氮杂衍生物

    公开(公告)号：US07192945B2

    公开(公告)日：2007-03-20

    申请号：US10451262

    申请日：2001-12-17

    申请人： Ingemar Starke ,  Mikael Dahlstrom ,  David Blomberg

    发明人： Ingemar Starke ,  Mikael Dahlstrom ,  David Blomberg

    IPC分类号： A61P3/06 ,  A61K31/55 ,  C07D281/10

    CPC分类号： C07D417/12 ,  A61K45/06 ,  C07D281/10 ,  C07F9/6536

    摘要： The present invention relates to compounds of the formula (I): (wherein variable groups are as defined within) pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and their use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described

    摘要翻译： 本发明涉及式（I）的化合物：（其中可变基团如本文所定义）其药学上可接受的盐，溶剂合物，这些盐及其前药的溶剂合物及其作为回肠胆汁转运（IBAT）抑制剂用于治疗的用途 的高脂血症。 还描述了其制备方法和含有它们的药物组合物

    1,5-Benzothiazepines and their use as hypolipidaemics
    9.
    发明授权
    1,5-Benzothiazepines and their use as hypolipidaemics 失效
    1,5-苯并硫氮杂及其作为降血脂药的用途

    公开(公告)号：US06906058B2

    公开(公告)日：2005-06-14

    申请号：US10220877

    申请日：2001-03-05

    申请人： Ingemar Starke ,  Mickael Dahlström ,  David Blomberg

    发明人： Ingemar Starke ,  Mickael Dahlström ,  David Blomberg

    IPC分类号： A61K31/554 ,  A61K45/00 ,  A61P1/16 ,  A61P3/06 ,  A61P43/00 ,  C07D281/10 ,  C07D417/12 ,  C07F9/6536 ,  A61K31/662 ,  C07D401/12

    CPC分类号： C07D417/12 ,  C07D281/10 ,  C07F9/6536

    摘要： The present invention relates to compounds of formula (I) wherein R1 and R2 are independently selected from C1-6alkyl; one of R4 and R5 is a group of formula (IA): R3, R6, R7, R8, R9, R10 and R11 and the other of R4 and R5 are as defined within, pharmaceutically acceptable salts, solvates, solvates of such salts and prodrugs thereof and there use as ileal bile acid transport (IBAT) inhibitors for the treatment of hyperlipidaemia. Processes for their manufacture and pharmaceutical compositions containing them are also described.

    摘要翻译： 本发明涉及其中R 1和R 2独立地选自C 1-6烷基的式（I）化合物; R 4和R 5之一是式（IA）的基团：R 3，R 6， R 7，R 8，R 9，R 10和R 11和R 11和 R 4和R 5中的另一个如本文所定义的药学上可接受的盐，溶剂化物，这些盐和前药的溶剂化物，并且用作回肠胆汁转运（IBAT ）抑制剂用于治疗高脂血症。 还描述了其制备方法和含有它们的药物组合物。