公开(公告)号：US20220281953A1

公开(公告)日：2022-09-08

申请号：US17504405

申请日：2021-10-18

申请人： INNOCOLL PHARMACEUTICALS LIMITED

发明人： Alexandra DIETRICH ,  Michael Myers ,  Stefan Schneid

IPC分类号： C07K14/78

摘要： There is a need to provide a collagen powder having desirable product characteristics, such as high fluid absorption capacity, while also having processing characteristics that allow commercial manufacturing and handling of the collagen powder. The present invention relates to a collagen powder, a method of manufacture thereof, and uses thereof. In particular, the present invention relates to a process for preparing a collagen powder, the process comprising the steps of providing a collagen source; adjusting the concentration of the collagen source; adjusting the pH of the collagen source; freezing the collagen source; dehydrating the frozen collagen; and degrading the dehydrated collagen to a powder.

公开(公告)号：USRE47826E1

公开(公告)日：2020-01-28

申请号：US14660681

申请日：2015-03-17

申请人： INNOCOLL PHARMACEUTICALS LIMITED

发明人： Michael Myers ,  Philip Wallace Reginald

IPC分类号： A61F2/02 ,  A61K31/13 ,  A61K9/00 ,  A61K31/445 ,  A61K31/21 ,  A61K31/381 ,  A61K31/164

摘要： The invention relates to a drug delivery device for providing local analgesia, local anesthesia or nerve blockade at a site in a human or animal in need thereof, the device comprising a fibrillar collagen matrix; and at least one drug substance selected from the group consisting of amino amide anesthetics, amino ester anesthetics and mixtures thereof, the at least one drug substance being substantially homogeneously dispersed in the collagen matrix, and the at least one drug substance being present in an amount sufficient to provide a duration of local analgesia, local anesthesia or nerve blockade which lasts for at least about one day after administration.

公开(公告)号：US20220213173A1

公开(公告)日：2022-07-07

申请号：US17700120

申请日：2022-03-21

申请人： INNOCOLL PHARMACEUTICALS LIMITED

发明人： Alexandra DIETRICH ,  Michael Myers

IPC分类号： C07K14/78 ,  A61L27/24 ,  C08L89/00 ,  C08L89/06 ,  A61K31/445 ,  A61K31/7036 ,  A61K47/42 ,  A61L27/54

摘要： The present invention relates to a modified collagen obtainable by providing isolated collagen; freezing the isolated collagen; dehydrating the frozen collagen; and maturing the dehydrated collagen. Also disclosed are methods of preparing the modified collagen and uses thereof.

公开(公告)号：US11746141B2

公开(公告)日：2023-09-05

申请号：US16537339

申请日：2019-08-09

申请人： INNOCOLL PHARMACEUTICALS LIMITED

发明人： Alexandra Dietrich ,  Michael Myers

IPC分类号： C07K1/12 ,  C07K14/78 ,  A61L27/24 ,  C08L89/00 ,  C08L89/06 ,  A61K31/445 ,  A61K31/7036 ,  A61K47/42 ,  A61L27/54 ,  A61K38/39

CPC分类号： C07K14/78 ,  A61K31/445 ,  A61K31/7036 ,  A61K47/42 ,  A61L27/24 ,  A61L27/54 ,  C08L89/00 ,  C08L89/06 ,  A61K38/39 ,  A61L2300/204 ,  A61L2300/23 ,  A61L2300/402 ,  A61L2300/406

摘要： The present invention relates to a modified collagen obtainable by providing isolated collagen; freezing the isolated collagen; dehydrating the frozen collagen; and maturing the dehydrated collagen. Also disclosed are methods of preparing the modified collagen and uses thereof.

公开(公告)号：US11623947B2

公开(公告)日：2023-04-11

申请号：US13858382

申请日：2013-04-08

申请人： Innocoll Pharmaceuticals Limited

发明人： Alexandra Dietrich ,  Michael Myers ,  Stefan Schneid

IPC分类号： A61K8/65 ,  C07K14/78

摘要： There is a need to provide a collagen powder having desirable product characteristics, such as high fluid absorption capacity, while also having processing characteristics that allow commercial manufacturing and handling of the collagen powder. The present invention relates to a collagen powder, a method of manufacture thereof, and uses thereof. In particular, the present invention relates to a process for preparing a collagen powder, the process comprising the steps of providing a collagen source; adjusting the concentration of the collagen source; adjusting the pH of the collagen source; freezing the collagen source; dehydrating the frozen collagen; and degrading the dehydrated collagen to a powder.