公开(公告)号：US20210155894A1

公开(公告)日：2021-05-27

申请号：US17159137

申请日：2021-01-26

Applicant: Inscripta, Inc.

Inventor： Richard Fox ,  Daniel Held ,  Eric Abbate ,  Michael Clay ,  Katherine Krouse ,  Nandini Krishnamurthy ,  Krishna Yerramsetty

IPC: C12N1/20 ,  C07K14/245

Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

公开(公告)号：US11078458B2

公开(公告)日：2021-08-03

申请号：US17159137

申请日：2021-01-26

Applicant: Inscripta, Inc.

Inventor： Richard Fox ,  Daniel Held ,  Eric Abbate ,  Michael Clay ,  Katherine Krouse ,  Nandini Krishnamurthy ,  Krishna Yerramsetty

IPC: C12N1/20 ,  C07K14/245

Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

公开(公告)号：US11566241B2

公开(公告)日：2023-01-31

申请号：US17492435

申请日：2021-10-01

Applicant: Inscripta, Inc.

Inventor： Andrea Halweg-Edwards ,  Thomas Hraha ,  Krishna Yerramsetty ,  Shea Lambert ,  Miles Gander ,  Matthew David Estes ,  Chad Douglas Sanada ,  Isaac David Wagner ,  Paul Hardenbol

IPC: C12N15/10 ,  G16B35/20 ,  G16B40/20 ,  G16B35/10

Abstract: Disclosed systems and methods relate to predicting the relative representation of genomic variants in an edited cell population, based on the editing cassette design representation in an editing cassette design library used to generate the edited cell population. A library of editing cassette designs is generated, and a feature vector, or sequence embedding, is developed for each design using natural language processing techniques. The feature vector may be based upon sequence attributes and editing kinetics of each cassette design as well as attributes that describe the library context. Features may include sequence embeddings generated from a neural network, linguistic-type distances, and statistical distance summaries thereof. The feature vectors are classified using one or more machine learning models, and the classified feature vectors are used to predict the representation of each design an edited cell population.

公开(公告)号：US20210317402A1

公开(公告)日：2021-10-14

申请号：US17355295

申请日：2021-06-23

Applicant: Inscripta, Inc.

Inventor： Eric Abbate ,  Katherine Krouse ,  Nandini Krishnamurthy ,  Richard Fox ,  Daniel Held ,  Michael Clay ,  Krishna Yerramsetty

IPC: C12N1/20 ,  C07K14/245

Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

公开(公告)号：US10920189B2

公开(公告)日：2021-02-16

申请号：US16904827

申请日：2020-06-18

Applicant: Inscripta, Inc.

Inventor： Richard Fox ,  Daniel Held ,  Eric Abbate ,  Michael Clay ,  Katherine Krouse ,  Nandini Krishnamurthy ,  Krishna Yerramsetty

IPC: C12N1/20 ,  C07K14/245

Abstract: The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.