公开(公告)号：US20210363481A1

公开(公告)日：2021-11-25

申请号：US17319006

申请日：2021-05-12

申请人： Inscripta, Inc.

发明人： Eric Abbate ,  Katherine Krouse ,  Richard Fox ,  Daniel Held ,  Michael Clay ,  Nandini Krishnamurthy

IPC分类号： C12N1/20 ,  C12N15/70

摘要： The present disclosure relates to various different types of mutations in the thrA gene in E. coli leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

公开(公告)号：US20210155894A1

公开(公告)日：2021-05-27

申请号：US17159137

申请日：2021-01-26

申请人： Inscripta, Inc.

发明人： Richard Fox ,  Daniel Held ,  Eric Abbate ,  Michael Clay ,  Katherine Krouse ,  Nandini Krishnamurthy ,  Krishna Yerramsetty

IPC分类号： C12N1/20 ,  C07K14/245

摘要： The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

公开(公告)号：US20220033829A1

公开(公告)日：2022-02-03

申请号：US17387780

申请日：2021-07-28

申请人： Inscripta, Inc.

发明人： Tyson Shepherd ,  Andrew Garst ,  Daniel Held ,  Eric Abbate

IPC分类号： C12N15/63 ,  C12N9/22 ,  C12N15/11

摘要： The present disclosure relates to compositions, methods, modules and automated integrated instrumentation for using sets of short, curated peptide barcodes to track nucleic acid-guided edits and the translated proteins that result from the edits as well as to create in vitro pathways.

公开(公告)号：US11078458B2

公开(公告)日：2021-08-03

申请号：US17159137

申请日：2021-01-26

申请人： Inscripta, Inc.

发明人： Richard Fox ,  Daniel Held ,  Eric Abbate ,  Michael Clay ,  Katherine Krouse ,  Nandini Krishnamurthy ,  Krishna Yerramsetty

IPC分类号： C12N1/20 ,  C07K14/245

摘要： The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

公开(公告)号：US20210095243A1

公开(公告)日：2021-04-01

申请号：US17026359

申请日：2020-09-21

申请人： Inscripta, Inc.

发明人： Bryan Leland ,  Michael Clay ,  Eric Abbate ,  Stephen Federowicz ,  Richard Fox

IPC分类号： C12N1/14 ,  C12N15/10 ,  C12N9/10

摘要： The present disclosure relates to various different types of mutations in S. cerevisiae leading to enhanced tyrosine production for, e.g., supplements and nutraceuticals.

公开(公告)号：US20210317402A1

公开(公告)日：2021-10-14

申请号：US17355295

申请日：2021-06-23

申请人： Inscripta, Inc.

发明人： Eric Abbate ,  Katherine Krouse ,  Nandini Krishnamurthy ,  Richard Fox ,  Daniel Held ,  Michael Clay ,  Krishna Yerramsetty

IPC分类号： C12N1/20 ,  C07K14/245

摘要： The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

公开(公告)号：US10920189B2

公开(公告)日：2021-02-16

申请号：US16904827

申请日：2020-06-18

申请人： Inscripta, Inc.

发明人： Richard Fox ,  Daniel Held ,  Eric Abbate ,  Michael Clay ,  Katherine Krouse ,  Nandini Krishnamurthy ,  Krishna Yerramsetty

IPC分类号： C12N1/20 ,  C07K14/245

摘要： The present disclosure relates to various different types of variants in E. coli coding and noncoding regions leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

公开(公告)号：US11787841B2

公开(公告)日：2023-10-17

申请号：US17319006

申请日：2021-05-12

申请人： Inscripta, Inc.

发明人： Eric Abbate ,  Katherine Krouse ,  Richard Fox ,  Daniel Held ,  Michael Clay ,  Nandini Krishnamurthy

IPC分类号： A61K39/108 ,  C07K14/245

CPC分类号： C07K14/245 ,  A61K39/0258

摘要： The present disclosure relates to various different types of mutations in the thrA gene in E. coli leading to enhanced lysine production for, e.g., supplements and nutraceuticals.

公开(公告)号：US20220267812A1

公开(公告)日：2022-08-25

申请号：US17676720

申请日：2022-02-21

申请人： Inscripta, Inc.

发明人： Andrew Garst ,  Daniel Held ,  Eric Abbate ,  Katherine Noon

IPC分类号： C12P7/10 ,  C12N15/10 ,  C12N1/20 ,  C12N15/70 ,  C12N9/22 ,  C12N15/11 ,  C12N15/52 ,  C10L1/02

摘要： The present disclosure provides multiplexed engineered cells, automated multi-module instruments and methods of producing biofuel producing cells for enhanced production of biofuels. This platform empowers users to design genetic variant libraries of insertions, swaps, and/or deletions, that can be intentionally or randomly positioned across the entire genome to generate engineered cell populations with improved properties for several common biofuel applications including, but not limited to, improved tolerance to biomass inhibitors, increased thermo-tolerance, increased ethanol production and/or tolerance, expanded carbon utilization abilities, and increased utilization of heterologous proteins or pathways.