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公开(公告)号:US11414385B2
公开(公告)日:2022-08-16
申请号:US16063877
申请日:2016-12-20
申请人: The University of Chicago , University of Leeds , The J. Craig Venter Institute , Institute For Systems Biology , U.S. Government, as represented by The Secretary of The Army Medical Command (MEDCOM) , The University of Strathclyde
发明人: Rima McLeod , Martin McPhillie , Colin W. G. Fishwick , Hernan Alejandro Lorenzi , Kai Wang , Taek-Kyun Kim , Yong Zhou , Leroy E. Hood , Ying Zhou , Kamal El Bissati , Mark Hickman , QiGui Li , Craig Roberts
IPC分类号: C07D215/233 , A61P33/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: Disclosed herein; are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
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公开(公告)号:US20140073516A1
公开(公告)日:2014-03-13
申请号:US13830326
申请日:2013-03-14
发明人: Leroy HOOD , Kai Wang , Inyoul Lee , Yong Zhou , Ji Hoon Cho , Dhimankrishna Ghosh
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要: Concentrations of certain miRNA, mRNA and/or protein markers in the biological fluids and/or tissues of a subject are used to determine the probability that the subject does or does not have Posttraumatic Stress Disorder (PTSD). The concentrations of these markers in fluids and/or tissues are different in subjects with PTSD as compared to subjects who do not suffer from this disorder.
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公开(公告)号:US09856532B2
公开(公告)日:2018-01-02
申请号:US13830326
申请日:2013-03-14
发明人: Leroy Hood , Kai Wang , Inyoul Lee , Yong Zhou , Ji Hoon Cho , Dhimankrishna Ghosh
CPC分类号: C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要: Concentrations of certain miRNA, mRNA and/or protein markers in the biological fluids and/or tissues of a subject are used to determine the probability that the subject does or does not have Posttraumatic Stress Disorder (PTSD). The concentrations of these markers in fluids and/or tissues are different in subjects with PTSD as compared to subjects who do not suffer from this disorder.
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公开(公告)号:US20230140413A1
公开(公告)日:2023-05-04
申请号:US17831049
申请日:2022-06-02
申请人: The University of Chicago , University of Leeds , The J. Craig Venter Institute , Institute For Systems Biology , U.S. Government, as represented by The Secretary of The Army Medical Command (MEDCOM) , The University of Strathclyde
发明人: Rima McLeod , Martin McPhillie , Colin W.G. Fishwick , Hernan Alejandro Lorenzi , Kai Wang , Taek-Kyun Kim , Yong Zhou , Leroy E. Hood , Ying Zhou , Kamal El Bissati , Mark Hickman , QiGui Li , Craig Roberts
IPC分类号: C07D215/233 , A61P33/06 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要: Disclosed herein are novel compounds for treating apicomplexan parasite related disorders, methods for their use; cell line and non-human animal models of the dormant parasite phenotype and methods for their use in identifying new drugs to treat apicomplexan parasite related disorders, and biomarkers to identify disease due to the parasite and its response to treatment.
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