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公开(公告)号：US20130225428A1
公开(公告)日：2013-08-29
申请号：US13691170
申请日：2012-11-30
发明人： Shizhen QIN , Leroy Hood
CPC分类号： C12Q1/6876 , G01N33/6893
摘要： New markers for diseased liver conditions have been identified. A combination of protein C (PROC) and retinol binding protein 4 (RBP4) in blood are biomarkers to distinguish patients at different stages of hepatic fibrosis due, for example, to chronic infection with hepatitis C virus (HCV). Also, alpha-1-B glycoprotein (A1BG), complement factor H (CFH) and insulin-like growth factor binding protein acid labile subunit (IGFALS) distinguish subjects with chronic or acute liver conditions such as hepatitis infection or liver fibrosis from healthy controls.
摘要翻译： 已经确定了患病肝脏疾病的新标志物。 血液中蛋白C（PROC）和视黄醇结合蛋白4（RBP4）的组合是生物标志物，以区分肝纤维化的不同阶段的患者，例如由于丙型肝炎病毒（HCV）的慢性感染。 此外，α-1-B糖蛋白（A1BG），补体因子H（CFH）和胰岛素样生长因子结合蛋白酸不稳定亚基（IGFALS）区分来自健康对照的慢性或急性肝病例如肝炎感染或肝纤维化的受试者 。
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公开(公告)号：US09856532B2
公开(公告)日：2018-01-02
申请号：US13830326
申请日：2013-03-14
发明人： Leroy Hood , Kai Wang , Inyoul Lee , Yong Zhou , Ji Hoon Cho , Dhimankrishna Ghosh
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178
摘要： Concentrations of certain miRNA, mRNA and/or protein markers in the biological fluids and/or tissues of a subject are used to determine the probability that the subject does or does not have Posttraumatic Stress Disorder (PTSD). The concentrations of these markers in fluids and/or tissues are different in subjects with PTSD as compared to subjects who do not suffer from this disorder.
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公开(公告)号：US20150252429A1
公开(公告)日：2015-09-10
申请号：US14439974
申请日：2013-10-31
发明人： Nathan D. Price , Leroy Hood , Jaeyun Sung , Donald Geman
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/158 , C12Q2600/16
摘要： The invention provides methods to identify various types of brain cancer tissue by comparing gene expression transcriptomes in tissue samples. A sequential method to discriminate among six different types of brain cancer is described. The invention relates to the field of markers for various types of brain cancer. More particularly, it relies on a sequential system for sorting individual cancer types.
摘要翻译： 本发明提供了通过比较组织样品中的基因表达转录组来鉴定各种类型的脑癌组织的方法。 描述了区分六种不同类型的脑癌的顺序方法。 本发明涉及各种脑癌的标志物领域。 更具体地，它依赖于用于分类各种癌症类型的顺序系统。
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公开(公告)号：US09103834B2
公开(公告)日：2015-08-11
申请号：US14100301
申请日：2013-12-09
发明人： Leroy Hood , Biaoyang Lin
IPC分类号： G01N33/53 , G01N33/574 , G01N33/68
CPC分类号： G01N33/57434 , G01N33/6842 , G01N33/6893
摘要： The present invention relates generally to methods for identifying drug side effects by detecting perturbations in organ-specific molecular blood fingerprints. The invention further relates to methods for identifying drug-specific organ-specific molecular blood fingerprints. As such, the present invention provides compositions comprising organ-specific proteins, detection reagents for detecting such proteins, and panels and arrays for determining organ-specific molecular blood fingerprints.
摘要翻译： 本发明一般涉及通过检测器官特异性分子血液指纹图中的扰动来鉴定药物副作用的方法。 本发明还涉及用于鉴定药物特异性器官特异性分子血液指纹图谱的方法。 因此，本发明提供了包含器官特异性蛋白质的组合物，用于检测这些蛋白质的检测试剂，以及用于测定器官特异性分子血液指纹图谱和阵列。
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公开(公告)号：US20140106981A1
公开(公告)日：2014-04-17
申请号：US14072651
申请日：2013-11-05
IPC分类号： G01N33/68
CPC分类号： G01N33/68 , G01N33/6845 , G01N2800/00 , G01N2800/52
摘要： The present invention relates generally to methods for identifying and using organ-specific proteins and transcripts. The present invention further provides compositions comprising organ-specific proteins and transcripts encoding the same, detection reagents for detecting such proteins and transcripts, and diagnostic panels, kits and arrays for measuring organ-specific proteins/transcripts in blood, biological tissue or other biological fluid.
摘要翻译： 本发明一般涉及鉴定和使用器官特异性蛋白质和转录物的方法。 本发明还提供了包含器官特异性蛋白质和编码其的转录物的组合物，用于检测这些蛋白质和转录物的检测试剂，以及用于测量血液，生物组织或其它生物液体中的器官特异性蛋白质/转录物的诊断板，试剂盒和阵列 。
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公开(公告)号：US20140228229A1
公开(公告)日：2014-08-14
申请号：US14100301
申请日：2013-12-09
发明人： Leroy Hood , Biaoyang Lin
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/57434 , G01N33/6842 , G01N33/6893
摘要： The present invention relates generally to methods for identifying drug side effects by detecting perturbations in organ-specific molecular blood fingerprints. The invention further relates to methods for identifying drug-specific organ-specific molecular blood fingerprints. As such, the present invention provides compositions comprising organ-specific proteins, detection reagents for detecting such proteins, and panels and arrays for determining organ-specific molecular blood fingerprints.
摘要翻译： 本发明一般涉及通过检测器官特异性分子血液指纹图中的扰动来鉴定药物副作用的方法。 本发明还涉及用于鉴定药物特异性器官特异性分子血液指纹图谱的方法。 因此，本发明提供了包含器官特异性蛋白质的组合物，用于检测这些蛋白质的检测试剂，以及用于测定器官特异性分子血液指纹图谱和阵列。
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