公开(公告)号：US20220073479A1

公开(公告)日：2022-03-10

申请号：US17414477

申请日：2019-12-20

Applicant: Intervet Inc.

Inventor： Harald Schmitt

IPC: C07D261/04

Abstract: The present invention relates to a novel method for preparing (5S)-4-[5-(3,5-di-chlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid, which can preferably be used in the synthesis of (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoro-Q methyl)-4H-isoxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-2-methyl-benzamide.

公开(公告)号：US20220017499A1

公开(公告)日：2022-01-20

申请号：US17311615

申请日：2019-12-12

Applicant: Intervet Inc.

Inventor： Christophe Pierre Alain Chassaing ,  Jingjun Yin ,  Licheng Song ,  Wensong Xiao ,  Edward Cleator ,  Thomas Dahmen ,  Daniel Salanta ,  Claudia Scheipers ,  Harald Schmitt

IPC: C07D405/14

Abstract: The application relates to processes for the preparation of 1-[(3R,4S)-4-cyanotetrahydropyran-3-yl]-3-[(2-fluoro-6-methoxy-4-pyridyl) amino]pyrazole-4-carboxamide (I) which include (i) a synthesis for bromo and iodo pyridine intermediates, (ii) a synthesis of a pyrazole ester intermediate which can be obtained in enantiopure form and (iii) the combination of these intermediates into compound (I).

公开(公告)号：US11530187B2

公开(公告)日：2022-12-20

申请号：US17414228

申请日：2019-12-20

Applicant: Intervet Inc.

Inventor： Harald Schmitt

IPC: C07D261/04

Abstract: The present invention relates to a novel method for preparing (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid, which can preferably be used in the synthesis of (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-2-methyl-benzamide.

公开(公告)号：US11548859B2

公开(公告)日：2023-01-10

申请号：US17414477

申请日：2019-12-20

Applicant: Intervet Inc.

Inventor： Harald Schmitt

IPC: C07D261/04

Abstract: The present invention relates to a novel method for preparing (5S)-4-[5-(3,5-di-chlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid, which can preferably be used in the synthesis of (5S)-4-[5-(3,5-dichlorophenyl)-5-(trifluoro-methyl)-4H-isoxazol-3-yl]-N-[2-oxo-2-(2,2,2-trifluoroethylamino)ethyl]-2-methyl-benzamide.

公开(公告)号：US20240316045A1

公开(公告)日：2024-09-26

申请号：US18263227

申请日：2022-01-26

Applicant: Intervet Inc. ,  Corteva Agriscience LLC

Inventor： James Edward Hunter ,  Lori Kay Lawler ,  Tony Kent Trullinger ,  Martin Joseph Walsh ,  Harald Schmitt ,  Anja Regina Heckeroth ,  Jürgen Lutz ,  Maria Daniela Fähsing ,  Hartmut Zoller

IPC: A61K31/505 ,  A61K31/167 ,  A61K31/44 ,  A61P33/14

CPC classification number: A61K31/505 ,  A61K31/167 ,  A61K31/44 ,  A61P33/14

Abstract: The present invention relates to cyclopropylamide compounds that are useful in the treatment of parasitic infestations of fish. The compounds have the formula (I).

公开(公告)号：US20240315993A1

公开(公告)日：2024-09-26

申请号：US18263211

申请日：2022-01-26

Applicant: Intervet Inc.

Inventor： James Edward Hunter ,  Lori Kay Lawler ,  Tony Kent Trullinger ,  Martin Joseph Walsh ,  Harald Schmitt ,  Anja Regina Heckeroth ,  Jürgen Lutz ,  Heike Williams ,  Hartmut Zoller ,  John Gerard Sheehan ,  Joshua M. Katzenstein

IPC: A61K31/167 ,  A61K31/277 ,  A61K31/341 ,  A61K31/404 ,  A61K31/44 ,  A61K31/505 ,  A61P33/14 ,  C07C233/66 ,  C07D213/81 ,  C07D239/28

CPC classification number: A61K31/167 ,  A61K31/277 ,  A61K31/341 ,  A61K31/404 ,  A61K31/44 ,  A61K31/505 ,  A61P33/14 ,  C07C233/66 ,  C07D213/81 ,  C07D239/28

Abstract: The present invention relates to cyclopropylamide compounds that are useful in the treatment of parasitic infestations of animals. The compounds have the formula (I).

公开(公告)号：US20240116854A1

公开(公告)日：2024-04-11

申请号：US18263203

申请日：2021-01-26

Applicant: Intervet Inc. ,  Corteva Agriscience LLC

Inventor： James Edward Hunter ,  Lori Kay Lawler ,  Tony Kent Trullinger ,  Martin Joseph Walsh ,  Harald Schmitt ,  Anja Regina Heckeroth ,  Jürgen Lutz ,  Maria Daniela Fähsing ,  Hartmut Zoller

IPC: C07C233/65 ,  A23K20/111 ,  A23K50/80 ,  A61P33/14 ,  C07C233/66 ,  C07C233/79

CPC classification number: C07C233/65 ,  A23K20/111 ,  A23K50/80 ,  A61P33/14 ,  C07C233/66 ,  C07C233/79 ,  C07C2601/02 ,  C07C2601/04

Abstract: The present invention relates to cyclopropylamide compounds that are useful in the treatment of parasitic infestations of fish. The compounds have the formula (I).

公开(公告)号：US12077514B2

公开(公告)日：2024-09-03

申请号：US17414214

申请日：2019-12-20

Applicant: Intervet Inc.

Inventor： Harald Schmitt

IPC: C07D261/04 ,  C07B55/00

CPC classification number: C07D261/04 ,  C07B55/00

Abstract: The present invention relates to a method for racemizing (5R)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid.