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公开(公告)号：US10190124B2
公开(公告)日：2019-01-29
申请号：US15069057
申请日：2016-03-14
Applicant: Intrexon Corporation
Inventor： Subba Reddy Palli , Mohan Basavaraju Kumar , Dean Ervin Cress , Ted Tsutomu Fujimoto
Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
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2.发明申请公开(公告)号：US20190071485A1
公开(公告)日：2019-03-07
申请号：US16117211
申请日：2018-08-30
Applicant: Intrexon Corporation
Inventor： Subba Reddy Palli , Marianna Zinovievna Kapitskaya
IPC: C07K14/705 , C12N15/63 , C07K14/72
Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel nuclear receptors comprising a substitution mutation and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene within a host cell using this inducible gene expression system.
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Patent Agency Ranking
公开(公告)号：US20160122771A1
公开(公告)日：2016-05-05
申请号：US14937355
申请日：2015-11-10
Applicant: Intrexon Corporation
Inventor： Tarlochan Singh DHADIALLA , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig , Mohan Philip
CPC classification number: C12N15/635 , A01K2217/05 , A61K48/00 , C07K14/721 , C07K2319/00 , C12N15/70 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/8217 , C12N15/8238 , C12N15/8241 , C12N15/85 , C12N15/861 , G01N33/6845
Abstract: The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.
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公开(公告)号：US10087231B2
公开(公告)日：2018-10-02
申请号：US14972901
申请日：2015-12-17
Applicant: Intrexon Corporation
Inventor： Subba Reddy Palli , Marianna Zinovievna Kapitskaya
IPC: G01N33/53 , C07K14/705 , C07K14/72 , C12N15/63
Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel nuclear receptors comprising a substitution mutation and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene within a host cell using this inducible gene expression system.
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5.发明申请Chimeric Retinoid X Receptors and Their Use in a Novel Ecdysone Receptor-Based Inducible Gene Expression System 审中-公开嵌合维甲酸X受体及其在新型蜕皮激素受体诱导型基因表达系统中的应用公开(公告)号：US20150150152A1
公开(公告)日：2015-05-28
申请号：US14551247
申请日：2014-11-24
Applicant: Intrexon Corporation
Inventor： Marianna Zinovievna KAPITSKAYA , Subba Reddy Palli
IPC: C12N15/63 , C07K14/39 , C07K14/005 , C07K14/72
CPC classification number: C12N15/635 , C07K14/005 , C07K14/39 , C07K14/70567 , C07K14/721 , C07K2319/00 , C07K2319/70 , C07K2319/74 , C07K2319/80 , C12N15/1055 , C12N15/63
Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel ecdysone receptor/chimeric retinoid X receptor-based inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large-scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
Abstract translation: 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及一种新的蜕皮激素受体/基于嵌合维甲酸X受体的诱导型基因表达系统和调节宿主细胞中基因表达的方法，用于诸如基因治疗，蛋白质和抗体的大规模生产， 基于高通量筛选测定，功能基因组学和转基因生物体中性状的调控。
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6.发明申请公开(公告)号：US20170096673A1
公开(公告)日：2017-04-06
申请号：US15293602
申请日：2016-10-14
Applicant: Intrexon Corporation
Inventor： Marianna Zinovievna KAPITSKAYA , Subba Reddy Palli
IPC: C12N15/63 , C07K14/72 , C07K14/705
CPC classification number: C12N15/635 , C07K14/005 , C07K14/39 , C07K14/70567 , C07K14/721 , C07K2319/00 , C07K2319/70 , C07K2319/74 , C07K2319/80 , C12N15/1055 , C12N15/63
Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to a novel ecdysone receptor/chimeric retinoid X receptor-based inducible gene expression system and methods of modulating gene expression in a host cell for applications such as gene therapy, large-scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.
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公开(公告)号：US20150067899A1
公开(公告)日：2015-03-05
申请号：US14478668
申请日：2014-09-05
Applicant: Intrexon Corporation
Inventor： Tarlochan Singh DHADIALLA , Dean Ervin Cress , Glenn Richard Carlson , Robert Eugene Hormann , Subba Reddy Palli , Arthur John Kudla , Ronald Phillip Herzig , Mohan Philip
CPC classification number: C12N15/635 , A01K2217/05 , A61K48/00 , C07K14/721 , C07K2319/00 , C12N15/70 , C12N15/74 , C12N15/80 , C12N15/81 , C12N15/8217 , C12N15/8238 , C12N15/8241 , C12N15/85 , C12N15/861 , G01N33/6845
Abstract: The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.
Abstract translation: 本发明涉及生物技术或遗传工程领域。 更具体地，本发明涉及在细胞内起作用以同时控制多个基因的定量表达的多重诱导型基因调控系统。
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