公开(公告)号：US20160257964A1

公开(公告)日：2016-09-08

申请号：US15069057

申请日：2016-03-14

Applicant: Intrexon Corporation

Inventor： Subba Reddy PALLI ,  Mohan Basavaraju Kumar ,  Dean Ervin Cress ,  Ted Tsutomu Fujimoto

IPC: C12N15/63 ,  C12N7/00 ,  C12N15/86

CPC classification number: C12N15/635 ,  C07K14/70567 ,  C07K14/721 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/10043 ,  C12P21/02

Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

公开(公告)号：US20160122771A1

公开(公告)日：2016-05-05

申请号：US14937355

申请日：2015-11-10

Applicant: Intrexon Corporation

Inventor： Tarlochan Singh DHADIALLA ,  Dean Ervin Cress ,  Glenn Richard Carlson ,  Robert Eugene Hormann ,  Subba Reddy Palli ,  Arthur John Kudla ,  Ronald Phillip Herzig ,  Mohan Philip

IPC: C12N15/63 ,  C12N15/85

CPC classification number: C12N15/635 ,  A01K2217/05 ,  A61K48/00 ,  C07K14/721 ,  C07K2319/00 ,  C12N15/70 ,  C12N15/74 ,  C12N15/80 ,  C12N15/81 ,  C12N15/8217 ,  C12N15/8238 ,  C12N15/8241 ,  C12N15/85 ,  C12N15/861 ,  G01N33/6845

Abstract: The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.

公开(公告)号：US20150067899A1

公开(公告)日：2015-03-05

申请号：US14478668

申请日：2014-09-05

Applicant: Intrexon Corporation

Inventor： Tarlochan Singh DHADIALLA ,  Dean Ervin Cress ,  Glenn Richard Carlson ,  Robert Eugene Hormann ,  Subba Reddy Palli ,  Arthur John Kudla ,  Ronald Phillip Herzig ,  Mohan Philip

IPC: C12N15/85 ,  G01N33/68 ,  C12N15/82 ,  C12N15/74 ,  C12N15/70 ,  C12N15/80 ,  C12N15/81

CPC classification number: C12N15/635 ,  A01K2217/05 ,  A61K48/00 ,  C07K14/721 ,  C07K2319/00 ,  C12N15/70 ,  C12N15/74 ,  C12N15/80 ,  C12N15/81 ,  C12N15/8217 ,  C12N15/8238 ,  C12N15/8241 ,  C12N15/85 ,  C12N15/861 ,  G01N33/6845

Abstract: The present invention relates to the field of biotechnology or genetic engineering. More specifically, the present invention relates to a multiple inducible gene regulation system that functions within cells to simultaneously control the quantitative expression of multiple genes.

Abstract translation: 本发明涉及生物技术或遗传工程领域。 更具体地，本发明涉及在细胞内起作用以同时控制多个基因的定量表达的多重诱导型基因调控系统。

公开(公告)号：US10190124B2

公开(公告)日：2019-01-29

申请号：US15069057

申请日：2016-03-14

Applicant: Intrexon Corporation

Inventor： Subba Reddy Palli ,  Mohan Basavaraju Kumar ,  Dean Ervin Cress ,  Ted Tsutomu Fujimoto

IPC: C12P21/06 ,  C12N15/63 ,  C07K14/705 ,  C07K14/72 ,  C12P21/02 ,  C12N7/00 ,  C12N15/86

Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a Group H nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.