公开(公告)号：US20180099155A1

公开(公告)日：2018-04-12

申请号：US15727292

申请日：2017-10-06

Applicant: Ion Beam Applications S.A.

Inventor： Damien PRIEELS ,  Erik VAN DER KRAAIJ ,  Sébastien HENROTIN ,  Caterina BRUSASCO

IPC: A61N5/10 ,  G01R33/48 ,  G01R33/483 ,  G01R33/56 ,  A61B5/055 ,  A61B5/00

CPC classification number: A61N5/1039 ,  A61B5/055 ,  A61B5/743 ,  A61N5/1049 ,  A61N5/1065 ,  A61N2005/1055 ,  A61N2005/1074 ,  A61N2005/1085 ,  A61N2005/1087 ,  G01R33/4808 ,  G01R33/4833 ,  G01R33/5608

Abstract: The present disclosure relates to a method and a medical apparatus for visualizing on magnetic resonance (MR) images a hadron beam path traversing an organic body. The present method may utilize artefacts in MR image acquisition provoked by the changes in properties of excitable atoms when irradiated by a hadron beam. By synchronizing the hadron pulses with different steps of MR data acquisition, it is possible to identify such artefacts and determine, based on their positions, the hadron beam path and the corresponding position of the Bragg peak.

公开(公告)号：US20180099157A1

公开(公告)日：2018-04-12

申请号：US15727379

申请日：2017-10-06

Applicant: Ion Beam Applications S.A.

Inventor： Damien PRIEELS ,  Erik VAN DER KRAAIJ ,  Sébastien HENROTIN ,  Caterina BRUSASCO

IPC: A61N5/10 ,  A61B5/055 ,  A61B5/00

CPC classification number: A61N5/1048 ,  A61B5/055 ,  A61B5/742 ,  A61B5/7425 ,  A61B5/743 ,  A61N5/103 ,  A61N5/1049 ,  A61N5/1067 ,  A61N5/1077 ,  A61N2005/1055 ,  A61N2005/1087 ,  G01R33/4808 ,  G01R33/4838 ,  G01R33/5602

Abstract: The present disclosure relates to a method and a medical apparatus for visualizing a hadron beam traversing an organic body. In one implementation, the method may include capturing a magnetic resonance (MR) image including a volume of irradiated excitable atoms surrounding a hadron beam and having a magnetic susceptibility modified by the hadron beam captured as a hyposignal. For example, a hyposignal may be obtained by saturating the spins of the irradiated excitable atoms before capturing an MR image based on excitation of excitable atoms not affected by the hadron beam.

公开(公告)号：US20180099154A1

公开(公告)日：2018-04-12

申请号：US15726836

申请日：2017-10-06

Applicant: Ion Beam Applications S.A.

Inventor： Damien PRIEELS

IPC: A61N5/10

CPC classification number: A61N5/1039 ,  A61B5/055 ,  A61B5/4836 ,  A61B6/032 ,  A61B6/037 ,  A61B6/0478 ,  A61B6/4258 ,  A61B6/48 ,  A61B6/5205 ,  A61B6/5247 ,  A61B8/085 ,  A61N5/1049 ,  A61N5/1064 ,  A61N2005/1052 ,  A61N2005/1055 ,  A61N2005/1058 ,  A61N2005/1087

Abstract: The present disclosure relates to a medical apparatus. In one implementation, the medical apparatus includes a hadron therapy device adapted for directing a hadron beam having an initial beam energy along a beam path to a target spot located inside a subject of interest; an MRI for acquiring a magnetic resonance (MR) image within an imaging volume having the target spot; a prompt-γ system adapted for acquiring a signal generated by the hadron beam; and a controller configured for computing an actual position of the Bragg peak of the hadron beam, based on the signal acquired by the PG system, and locating the actual position of the Bragg peak on the MR image.

公开(公告)号：US20180099153A1

公开(公告)日：2018-04-12

申请号：US15726681

申请日：2017-10-06

Applicant: Ion Beam Applications S.A.

Inventor： Damien PRIEELS

IPC: A61N5/10

CPC classification number: A61N5/1039 ,  A61B5/055 ,  A61B5/4848 ,  A61B6/032 ,  A61B6/037 ,  A61B6/4092 ,  A61B6/4258 ,  A61N5/1049 ,  A61N5/1065 ,  A61N5/1081 ,  A61N2005/1052 ,  A61N2005/1055 ,  A61N2005/1061 ,  A61N2005/1087 ,  A61N2005/109 ,  G01N23/025 ,  G01N23/04

Abstract: The present disclosure relates to a medical apparatus including a hadron therapy device directing an imaging hadron beam along a beam path. The beam path crosses a subject of interest including a plurality of tissues having upstream and downstream boundaries and a target tissue having a target spot. The apparatus further includes a magnetic resonance imaging device for acquiring magnetic resonance data within an imaging volume including a portion of the subject of interest including the target spot and at least the portion of the beam path between the upstream boundary and the target spot. The apparatus further includes a hadron radiography system (HRS) acquiring a signal generated by the imaging hadron beam and a controller for determining a water equivalent path length of the beam path between upstream and downstream boundaries based on at least the signal.

公开(公告)号：US20150087882A1

公开(公告)日：2015-03-26

申请号：US14491743

申请日：2014-09-19

Applicant: ION BEAM APPLICATIONS, S.A. ,  Technische Universität Dresden ,  Helmholtz-Zentrum Dresden-Rossendorf e.V.

Inventor： Guntram PAUSCH ,  Christian GOLNIK ,  Wolfgang ENGHARDT ,  Guillaume JANSSENS ,  Damien PRIEELS ,  Julien SMEETS ,  Francois VANDER STAPPEN

IPC: A61N5/10

CPC classification number: A61N5/1067 ,  A61N2005/1052 ,  A61N2005/1074 ,  A61N2005/1087 ,  G01T1/24 ,  G01T1/29

Abstract: The invention is related to a method for monitoring a range of a particle beam in a target. The method is using gamma detectors for detecting prompt gammas produced in the target. The time differences between the time of detecting a gamma quantum and a time of emission of a particle or a bunch of particles from the radiation device are determined. A statistical distribution of those time difference is used to deduce information related to the range of the beam. The invention is also related to an apparatus for monitoring a range based on measured time profiles of detected prompt gammas.

Abstract translation: 本发明涉及用于监测目标中的粒子束的范围的方法。 该方法使用γ检测器来检测目标中产生的瞬时伽马值。 确定检测伽马量子的时间与发射来自辐射装置的粒子或一束粒子之间的时间差。 这些时差的统计分布用于推导出与波束范围有关的信息。 本发明还涉及一种用于基于检测到的提示伽马的测量时间曲线来监视范围的装置。