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    Bioluminescent novelty items
    6.
    发明授权
    Bioluminescent novelty items 失效
    生物发光新奇物品

    公开(公告)号：US06247995B1

    公开(公告)日：2001-06-19

    申请号：US08597274

    申请日：1996-02-06

    申请人： Bruce Bryan

    发明人： Bruce Bryan

    IPC分类号： A63H3330

    CPC分类号： F21V33/0028 ,  A23G3/366 ,  A23G3/50 ,  A23G9/363 ,  A23G9/44 ,  A23L29/06 ,  A23L29/065 ,  A23P10/30 ,  A24D3/14 ,  A45D34/00 ,  B05B7/2416 ,  B05C17/00553 ,  F21K2/00 ,  F21K2/06 ,  F21W2121/02 ,  F41B9/004

    摘要： Systems and apparatus for generating bioluminescence, and combinations of these systems and apparatus with inanimate articles of manufacture to produce novelty items are provided. These novelty items, which are articles of manufacture, are designed for entertainment, recreation and amusement, include, toys, paints, slimy play material, textiles, particularly clothing, bubbles in bubble making toys and other toys that produce bubbles, balloons, personal items, such as bath powders, body lotions, gels, powders and creams, toothpastes and other dentifrices, soaps, body paints, and bubble bath, foods, such as gelatins, icings and frostings, beverages such as beer, wine, champagne, soft drinks, and ice cubes, fountains, including liquid “fireworks” and other such jets or sprays or aerosols of compositions that are solutions, mixtures, suspensions, powders, pastes, particles or other suitable formulation.

    摘要翻译： 提供了用于产生生物发光的系统和装置，以及这些系统和装置与无生命制品的组合以产生新颖物品。 这些新品是制作娱乐，娱乐和娱乐的新奇物品，包括玩具，油漆，泥土玩具材料，纺织品，特别是服装，泡泡玩具中的气泡和其他产生气泡，气球，个人物品的玩具 例如浴粉，身体乳液，凝胶，粉末和乳膏，牙膏和其他洁牙剂，肥皂，身体涂料和泡泡浴，食品如明胶，结冰和结霜，饮料如啤酒，葡萄酒，香槟，软饮料 和冰块，喷泉，包括液体“烟花”和其他溶液，混合物，悬浮液，粉末，糊剂，颗粒或其他合适制剂的组合物的喷雾或喷雾剂或喷雾剂。

    Bioluminescent Endoscopy Methods and Compounds
    7.
    发明申请
    Bioluminescent Endoscopy Methods and Compounds 审中-公开
    生物发光内窥镜检查方法和化合物

    公开(公告)号：US20130058872A1

    公开(公告)日：2013-03-07

    申请号：US13610242

    申请日：2012-09-11

    申请人： Philip T. Neff ,  Bruce Bryan ,  Randall B. Murphy

    发明人： Philip T. Neff ,  Bruce Bryan ,  Randall B. Murphy

    IPC分类号： A61K49/00

    CPC分类号： G01N21/763 ,  C07D487/04 ,  G01N21/6456

    摘要： Bioluminescent endoscopy methods in which bioluminescent generating system components are combined ex vivo immediately prior to injection or infusion into a tissue area of interest to enable bioluminescent viewing of the tissue. The bioluminescent generating system components are combined by simultaneous injection into a Y tube or other in-line mixing chamber receiving fluid inputs from two or more fluid conduits and providing a fluid output to at least one fluid conduit. The mixed components which are the output of such multi lumen mixing system is injected into a hollow viscus organ or otherwise applied to organs and/or tissues of the body.

    摘要翻译： 生物发光内窥镜检查方法，其中将生物发光发生系统组分在注射或注射到目的组织区域之前离体组合以使组织的生物发光观察。 生物发光发生系统部件通过同时注射到Y管或其它在线混合室中，从两个或更多个流体导管接收流体输入，并向至少一个流体导管提供流体输出。 作为这种多腔混合系统的输出的混合成分被注射到空心粘液器官中或以其它方式施加到身体的器官和/或组织上。

    Bioluminescent endoscopy methods and compounds
    8.
    发明授权
    Bioluminescent endoscopy methods and compounds 有权
    生物发光内窥镜检查方法和化合物

    公开(公告)号：US08431698B2

    公开(公告)日：2013-04-30

    申请号：US12201680

    申请日：2008-08-29

    申请人： Philip T. Neff ,  Randall B. Murphy ,  Bruce Bryan

    发明人： Philip T. Neff ,  Randall B. Murphy ,  Bruce Bryan

    IPC分类号： C07D491/00 ,  C07D495/00 ,  C07D497/00

    CPC分类号： G01N21/763 ,  C07D487/04 ,  G01N21/6456

    摘要： Bioluminescent endoscopy methods and compounds, wherein an anatomical object is examined by means of filling, perfusing, intubating, injecting, or otherwise administering a solution containing a bioluminescent substance or a mixture of luciferin and luciferase which produces bioluminescence, wherein a color or monochrome image of the object is constituted using the images and information based on bioluminescent emitted by the bioluminescent substance. Procedures are demonstrated which allow bioluminescent solutions to be perfused into certain tissue regions, such as but not limited to the common biliary duct, genitourinary tract, gastro-intestinal tract, cardiovascular system and lymphatic system wherein said structures may be conveniently visualized during surgery to avoid damage to these structures. Such images may also be combined with visual light images. Methods of detection of cancer cells using bioluminescence are provided. Preferred embodiments disclosed include membrane permeant coelenterazine analogs.

    摘要翻译： 生物发光内窥镜检查方法和化合物，其中通过填充，灌注，插管，注射或以其他方式施用含有生物发光物质或产生生物发光的荧光素和荧光素酶的混合物的溶液来检查解剖学对象，其中， 使用基于由生物发光物质发射的生物发光的图像和信息构成该对象。 证明了允许将生物发光溶液灌注到某些组织区域中的程序，例如但不限于常见的胆管，泌尿生殖道，胃肠道，心血管系统和淋巴系统，其中所述结构可在手术期间方便地可视化以避免 损坏这些结构。 这些图像也可以与视觉光图像组合。 提供了使用生物发光检测癌细胞的方法。 公开的优选实施方案包括膜渗透性肠溶纤维素类似物。

    Bioluminescent Endoscopy Methods And Compounds
    9.
    发明申请
    Bioluminescent Endoscopy Methods And Compounds 有权
    生物发光内窥镜检查方法和化合物

    公开(公告)号：US20090081129A1

    公开(公告)日：2009-03-26

    申请号：US12201680

    申请日：2008-08-29

    申请人： Philip T. Neff ,  Randall B. Murphy ,  Bruce Bryan

    发明人： Philip T. Neff ,  Randall B. Murphy ,  Bruce Bryan

    IPC分类号： A61K49/00 ,  C07D487/02 ,  C12Q1/66

    CPC分类号： G01N21/763 ,  C07D487/04 ,  G01N21/6456

    摘要： Bioluminescent endoscopy methods and compounds, wherein an anatomical object is examined by means of filling, perfusing, intubating, injecting, or otherwise administering a solution containing a bioluminescent substance or a mixture of luciferin and luciferase which produces bioluminescence, wherein a color or monochrome image of the object is constituted using the images and information based on bioluminescent emitted by the bioluminescent substance. Procedures are demonstrated which allow bioluminescent solutions to be perfused into certain tissue regions, such as but not limited to the common biliary duct, genitourinary tract, gastro-intestinal tract, cardiovascular system and lymphatic system wherein said structures may be conveniently visualized during surgery to avoid damage to these structures. Such images may also be combined with visual light images. Methods of detection of cancer cells using bioluminescence are provided. Preferred embodiments disclosed include membrane permeant coelenterazine analogs.

    摘要翻译： 生物发光内窥镜检查方法和化合物，其中通过填充，灌注，插管，注射或以其他方式施用含有生物发光物质或产生生物发光的荧光素和荧光素酶的混合物的溶液来检查解剖学对象，其中， 使用基于由生物发光物质发射的生物发光的图像和信息构成该对象。 证明了允许将生物发光溶液灌注到某些组织区域中的程序，例如但不限于常见的胆管，泌尿生殖道，胃肠道，心血管系统和淋巴系统，其中所述结构可在手术期间方便地可视化以避免 损坏这些结构。 这些图像也可以与视觉光图像组合。 提供了使用生物发光检测癌细胞的方法。 公开的优选实施方案包括膜渗透性肠溶纤维素类似物。

    Detection and visualization of neoplastic tissues and other tissues
    10.
    发明授权
    Detection and visualization of neoplastic tissues and other tissues 失效
    肿瘤组织和其他组织的检测和可视化

    公开(公告)号：US06416960B1

    公开(公告)日：2002-07-09

    申请号：US08908909

    申请日：1997-08-08

    申请人： Bruce Bryan

    发明人： Bruce Bryan

    IPC分类号： G01N33574

    CPC分类号： A61K49/0013 ,  A61K47/6851 ,  C12Q1/66 ,  G01N33/533 ,  G01N33/574 ,  G01N33/581 ,  G01N33/582

    摘要： Diagnostic systems that rely on bioluminescence for visualizing tissues in situ are provided. The systems are particularly useful for visualizing and detecting neoplastic tissue and specialty tissue during surgical procedures. Kits that provide the components of the systems and methods using the systems for visualizing the tissue are also provided. The systems include compositions containing conjugates that include a tissue specific, particularly a tumor-specific, targeting agent linked to a targeted agent, a luciferase or luciferin. The systems also include a second composition that contains the remaining components of a bioluminescence generating reaction. Administration of the compositions results production of light by targeted tissues that permits the detection and localization of neoplastic tissue for surgical removal. Therapeutic methods in which photosensitizing compounds are administered are also provided.

    摘要翻译： 提供了依靠生物发光来原位观察组织的诊断系统。 该系统在外科手术过程中可视化和检测肿瘤组织和特殊组织特别有用。 还提供了提供使用用于可视化组织的系统的系统和方法的组件的套件。 该系统包括含有缀合物的组合物，其包含组织特异性，特别是与靶向药剂，荧光素酶或荧光素相连的肿瘤特异性靶向剂。 该系统还包括含有生物发光反应的剩余组分的第二组合物。 组合物的施用导致通过靶组织产生光，其允许检测和定位肿瘤组织用于手术切除。 还提供了施用光敏化合物的治疗方法。