-
公开(公告)号:US08252785B2
公开(公告)日:2012-08-28
申请号:US12898295
申请日:2010-10-05
申请人: Iris Kauffmann-Hefner , Norbert Hauel , Rainer Walter , Heiner Ebel , Henri Doods , Angelo Ceci , Annette Schuler-Metz , Ingo Konetzki
发明人: Iris Kauffmann-Hefner , Norbert Hauel , Rainer Walter , Heiner Ebel , Henri Doods , Angelo Ceci , Annette Schuler-Metz , Ingo Konetzki
IPC分类号: A61K31/55 , A61K31/445 , A61K31/495
CPC分类号: C07D401/02 , C07C311/29 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/06 , C07D223/04 , C07D403/04 , C07D403/06
摘要: The present invention relates to compounds of general formula I wherein A, B, D, Y, R1, R2, R3, R4 and R5 are defined as in the specification, the enantiomers, the diastereomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.
摘要翻译: 本发明涉及通式I的化合物,其中A,B,D,Y,R 1,R 2,R 3,R 4和R 5如说明书中所定义,其对映异构体,非对映异构体,混合物及其盐,特别是 其有机或无机酸或碱的生理上可接受的盐,其具有有价值的性质,其制备,含有药理学有效化合物的药物组合物,其制备及其用途。
-
公开(公告)号:US07858618B2
公开(公告)日:2010-12-28
申请号:US11840395
申请日:2007-08-17
申请人: Iris Kauffmann-Hefner , Norbert Hauel , Rainer Walter , Heiner Ebel , Henri Doods , Angelo Ceci , Annette Schuler-Metz , Ingo Konetzki
发明人: Iris Kauffmann-Hefner , Norbert Hauel , Rainer Walter , Heiner Ebel , Henri Doods , Angelo Ceci , Annette Schuler-Metz , Ingo Konetzki
IPC分类号: A61K31/5375
CPC分类号: C07D401/02 , C07C311/29 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/06 , C07D223/04 , C07D403/04 , C07D403/06
摘要: The present invention relates to compounds of general formula I wherein A, B, D, Y, R1, R2, R3, R4 and R5 are defined as in the specification, the enantiomers, the diastereomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.
摘要翻译: 本发明涉及通式I的化合物,其中A,B,D,Y,R 1,R 2,R 3,R 4和R 5如说明书中所定义,其对映异构体,非对映异构体,混合物及其盐,特别是 其有机或无机酸或碱的生理上可接受的盐,其具有有价值的性质,其制备,含有药理学有效化合物的药物组合物,其制备及其用途。
-
公开(公告)号:US20090137545A1
公开(公告)日:2009-05-28
申请号:US11840395
申请日:2007-08-17
申请人: Iris Kauffmann-Hefner , Norbert Hauel , Rainer Walter , Heiner Ebel , Henri Doods , Angelo Ceci , Annette Schuler-Metz , Ingo Konetzki
发明人: Iris Kauffmann-Hefner , Norbert Hauel , Rainer Walter , Heiner Ebel , Henri Doods , Angelo Ceci , Annette Schuler-Metz , Ingo Konetzki
IPC分类号: A61K31/00
CPC分类号: C07D401/02 , C07C311/29 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/06 , C07D223/04 , C07D403/04 , C07D403/06
摘要: The present invention relates to compounds of general formula I wherein A, B, D, Y, R1, R2, R3, R4 and R5 are defined as in the specification, the enantiomers, the diastereomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.
摘要翻译: 本发明涉及通式I的化合物,其中A,B,D,Y,R 1,R 2,R 3,R 4和R 5如说明书中所定义,其对映异构体,非对映异构体,混合物及其盐,特别是 其有机或无机酸或碱的生理上可接受的盐,其具有有价值的性质,其制备,含有药理学有效化合物的药物组合物,其制备及其用途。
-
公开(公告)号:US08394805B2
公开(公告)日:2013-03-12
申请号:US12672460
申请日:2008-08-12
申请人: Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
发明人: Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
IPC分类号: A61K31/551 , A61K31/4965 , C07D243/08 , C07D241/04
CPC分类号: C07D241/04 , A61K31/495 , C07D243/08 , C07D295/155
摘要: Novel compounds of which the following is exemplary:
摘要翻译: 以下是示例性的新型化合物:
-
公开(公告)号:US08450306B2
公开(公告)日:2013-05-28
申请号:US12672650
申请日:2008-08-12
申请人: Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
发明人: Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
IPC分类号: A61K31/551 , A61K31/4965 , C07D243/08 , C07D243/04 , A61P25/00 , A61P29/00
CPC分类号: C07D205/04 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/06 , C07D223/04 , C07D295/14 , C07D295/18 , C07D401/02 , C07D403/04
摘要: Novel compounds which are useful for treating acute pain, visceral pain, neuropathic pain, inflammatory/pain receptor-mediated pain, tumor pain and headache diseases. The following is exemplary:
摘要翻译: 可用于治疗急性疼痛,内脏痛,神经性疼痛,炎症/疼痛受体介导的疼痛,肿瘤疼痛和头痛疾病的新型化合物。 以下是示范:
-
公开(公告)号:US08865702B2
公开(公告)日:2014-10-21
申请号:US12669970
申请日:2008-07-23
申请人: Iris Kauffmann-Hefner , Angelo Ceci , Henri Doods , Norbert Hauel , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
发明人: Iris Kauffmann-Hefner , Angelo Ceci , Henri Doods , Norbert Hauel , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
IPC分类号: C07D223/16 , C07D401/14 , C07D217/06 , C07D487/04 , C07D471/10 , C07D211/58 , C07D209/40 , C07D209/44
CPC分类号: C07D401/14 , C07D209/40 , C07D209/44 , C07D211/58 , C07D217/06 , C07D223/16 , C07D471/10 , C07D487/04
摘要: Disclosed are compounds of the formula I wherein A, Y, R1, R2, R3, R4 and R5 are defined, suitable for treating diseases and symptoms of diseases caused at least to some extent by stimulation of bradykinin-B1 receptors, the preparation thereof and the use thereof.
摘要翻译: 公开了式I的化合物,其中A,Y,R 1,R 2,R 3,R 4和R 5的定义适用于通过刺激缓激肽B1受体至少在某种程度上引起的疾病和症状的治疗,其制备和 其使用。
-
公开(公告)号:US20110294775A1
公开(公告)日:2011-12-01
申请号:US12672650
申请日:2008-08-12
申请人: Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
发明人: Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
IPC分类号: A61K31/397 , C07C311/29 , C07D211/56 , C07D403/04 , C07D241/08 , C07D401/06 , C07D205/04 , C07D207/14 , C07D305/08 , A61K31/495 , A61K31/40 , A61K31/18 , A61K31/5375 , A61K31/445 , A61K31/4025 , A61K31/496 , A61K31/4453 , A61K31/337 , A61P29/00 , C07D295/135
CPC分类号: C07D205/04 , C07C311/29 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/08 , C07D207/06 , C07D223/04 , C07D295/14 , C07D295/18 , C07D401/02 , C07D403/04
摘要: Novel compounds which are useful for treating acute pain, visceral pain, neuropathic pain, inflammatory/pain receptor-mediated pain, tumour pain and headache diseases. The following is exemplary:
摘要翻译: 可用于治疗急性疼痛,内脏痛,神经性疼痛,炎症/疼痛受体介导的疼痛,肿瘤疼痛和头痛疾病的新型化合物。 以下是示范:
-
公开(公告)号:US20110046106A1
公开(公告)日:2011-02-24
申请号:US12865436
申请日:2009-02-05
申请人: Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
发明人: Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
IPC分类号: A61K31/397 , C07D403/06 , C07D401/06 , A61K31/454 , C07D401/14 , C07D211/06 , A61K31/4453 , C07D241/04 , A61K31/495 , A61K31/4545 , A61P29/00
CPC分类号: C07D403/06 , C07D295/125 , C07D401/04 , C07D401/06 , C07D407/14
摘要: The present invention relates to compounds of general formula I wherein A, B, R1, R2 and R3 are defined as in claim 1, the enantiomers, the diastereomers, the mixtures and the salts thereof, particularly the physiologically acceptable salts thereof with organic or inorganic acids or bases, which have valuable properties, the preparation thereof, the pharmaceutical compositions containing the pharmacologically effective compounds, the preparation thereof and the use thereof.
摘要翻译: 本发明涉及通式I的化合物,其中A,B,R 1,R 2和R 3如权利要求1中所定义,对映异构体,非对映体,其混合物和盐,特别是其与有机或无机的生理学上可接受的盐 具有有价值性质的酸或碱,其制备方法,含有药理学有效化合物的药物组合物,其制备方法及其用途。
-
公开(公告)号:US20100197664A1
公开(公告)日:2010-08-05
申请号:US12669970
申请日:2008-07-23
申请人: Iris Kauffmann-Hefner , Angelo Ceci , Henri Doods , Norbert Hauel , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
发明人: Iris Kauffmann-Hefner , Angelo Ceci , Henri Doods , Norbert Hauel , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
IPC分类号: A61K31/55 , C07D401/14 , A61K31/4545 , A61K31/496 , C07D403/14 , A61K31/438 , C07D223/16 , C07D217/06 , A61K31/47 , A61P29/00 , A61P25/06 , A61P35/00
CPC分类号: C07D401/14 , C07D209/40 , C07D209/44 , C07D211/58 , C07D217/06 , C07D223/16 , C07D471/10 , C07D487/04
摘要: Disclosed are compounds of the formula I wherein A, Y, R1, R2, R3, R4 and R5 are defined, suitable for treating diseases and symptoms of diseases caused at least to some extent by stimulation of bradykinin-B1 receptors, the preparation thereof and the use thereof.
摘要翻译: 公开了式I的化合物,其中A,Y,R 1,R 2,R 3,R 4和R 5的定义适用于通过刺激缓激肽B1受体至少在某种程度上引起的疾病和症状的治疗,其制备和 其使用。
-
公开(公告)号:US20110098282A1
公开(公告)日:2011-04-28
申请号:US12672460
申请日:2008-08-12
申请人: Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
发明人: Norbert Hauel , Angelo Ceci , Henri Doods , Iris Kauffmann-Hefner , Ingo Konetzki , Annette Schuler-Metz , Rainer Walter
IPC分类号: A61K31/551 , A61K31/4965 , C07D243/08 , C07D241/04 , A61P25/00 , A61P29/00
CPC分类号: C07D241/04 , A61K31/495 , C07D243/08 , C07D295/155
摘要: Novel compounds of which the following is exemplary:
摘要翻译: 以下是示例性的新型化合物:
-
-
-
-
-
-
-
-
-