利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

5 条记录 (耗时 0.029 秒)

    Treatment of systemic lupus erythematosus by down-regulating the autoimmune response to autoantigens
    1.
    发明申请
    Treatment of systemic lupus erythematosus by down-regulating the autoimmune response to autoantigens 审中-公开
    通过下调对自身抗原的自身免疫反应来治疗系统性红斑狼疮

    公开(公告)号：US20060030524A1

    公开(公告)日：2006-02-09

    申请号：US11179820

    申请日：2005-07-13

    申请人： Irun Cohen ,  Varda Rotter ,  Neta Erez ,  Johannes Herkel

    发明人： Irun Cohen ,  Varda Rotter ,  Neta Erez ,  Johannes Herkel

    IPC分类号： A61K48/00 ,  A61K38/17

    CPC分类号： C07K14/4746 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  C07K16/18 ,  C07K16/4241 ,  G01N33/564 ,  G01N2800/104

    摘要： Systemic lupus erythematosus (SLE) can be prevented or treated by down-regulating the autoimmune response to the C-terminal-DNA-binding domain of the p53 protein (p53) by an active principle selected from the group consisting of: (i) a peptide of, or comprising, the C-terminal DNA-binding domain of the p53 protein; (ii) a monoclonal antibody (mAb) specific for said domain of p53 (Ab1), and fragments thereof; (iii) an mAb specific for Ab1 (hereinafter Ab2), and fragments thereof; (iv) a peptide based on a complementarity determining region (CDR) of the heavy or light chain of said Ab1 or Ab2; (v) a DNA molecule coding for (i) and (iv) of for the variable region of said Ab1 and Ab2 of (ii) and (iii); and (vi) T cells specific for (i) to (iv), fragments thereof, T cell receptor (TCR) thereof and peptides comprising the variable region of said TCR. SLE can also be diagnosed by assaying for antibodies (Ab1) against the C-terminal DNA-binding domain of p53 or antibodies (Ab2) specific to the Ab1 antibodies.

    摘要翻译： 可以通过选自以下的活性成分下调对自身免疫应答p53蛋白（p53）的C末端-DNA结合结构域的自身免疫应答来防止或治疗系统性红斑狼疮（SLE）：（i） 或包含p53蛋白的C-末端DNA结合结构域的肽; （ii）对所述p53结构域（Ab1）特异的单克隆抗体（mAb）及其片段; （iii）Ab1（以下称Ab2）特异性的mAb及其片段; （iv）基于所述Ab1或Ab2的重链或轻链的互补决定区（CDR）的肽; （v）编码（i）和（iv）的（ii）和（iii）所述Ab1和Ab2的可变区的DNA分子; 和（vi）特异于（i）至（iv）的T细胞，其片段，T细胞受体（TCR）和包含所述TCR的可变区的肽。 也可以通过测定针对p53的C末端DNA结合结构域的抗体（Ab1）或Ab1抗体特异性抗体（Ab2）来诊断SLE。