公开(公告)号：US20070020748A1

公开(公告)日：2007-01-25

申请号：US10555033

申请日：2004-04-28

申请人： Itsuro Motegi ,  Hirofumi Matsuzaki ,  Hideyoshi Kitahara ,  Mitsuhaya Tsukamoto ,  Kouji Shimogawa ,  Masataka Magoori ,  Akira Higuchi

发明人： Itsuro Motegi ,  Hirofumi Matsuzaki ,  Hideyoshi Kitahara ,  Mitsuhaya Tsukamoto ,  Kouji Shimogawa ,  Masataka Magoori ,  Akira Higuchi

IPC分类号： C12M1/34

CPC分类号： G01N33/68 ,  B01D9/00 ,  B01D9/0077 ,  C30B7/00 ,  C30B7/02 ,  C30B29/58 ,  G01N35/028 ,  G01N2035/0425

摘要： The present invention is intended to provide an apparatus for screening protein crystallization conditions that can screen protein crystallization conditions efficiently by the vapor diffusion method using the sitting drop technique. In order to achieve the above-mentioned object, in an apparatus for screening protein crystallization conditions that screens protein crystallization conditions using the sitting drop technique that is one of the techniques of protein crystallization to be carried out by the vapor diffusion method, an apparatus 2 for preparing a crystallization plate that includes a dispensing means for dispensing a protein solution and a crystallization solution in wells of the crystallization plate and a seal attachment unit that seals the wells that have been subjected to dispensation is connected to a protein crystal detection apparatus 5 that detects protein crystals produced in the crystallization plate in a thermostatic chamber that stores the crystallization plate that has been subjected to the dispensing in a predetermined environment. Accordingly, the crystallization plate is transferred automatically and thus screening is carried out efficiently and automatically.

摘要翻译： 本发明旨在提供一种用于筛选蛋白质结晶条件的装置，其可以通过使用坐式技术的蒸气扩散法有效地筛选蛋白质结晶条件。 为了实现上述目的，在使用通过蒸气扩散法进行蛋白质结晶的技术之一的坐式滴定技术筛选蛋白质结晶条件的蛋白质结晶条件的装置中，装置2 用于制备结晶板，其包括用于在结晶板的孔中分配蛋白质溶液和结晶溶液的分配装置和将经过分配的孔密封的密封附着单元连接到蛋白质晶体检测装置5，蛋白质晶体检测装置5 检测在恒温室中在结晶板中产生的蛋白质晶体，所述恒温室存储在预定环境中进行了分散的结晶板。 因此，结晶板被自动转印，从而有效且自动地进行筛选。

公开(公告)号：US06299840B1

公开(公告)日：2001-10-09

申请号：US09281223

申请日：1999-03-30

申请人： Eiji Watanabe ,  Kanji Yahiro ,  Akira Higuchi ,  Naoki Miyazaki ,  Kenichi Kuroda ,  Kenji Ishiyama ,  Takashi Daikoku ,  Hideyoshi Kitahara

发明人： Eiji Watanabe ,  Kanji Yahiro ,  Akira Higuchi ,  Naoki Miyazaki ,  Kenichi Kuroda ,  Kenji Ishiyama ,  Takashi Daikoku ,  Hideyoshi Kitahara

IPC分类号： G01N2100

CPC分类号： G01N35/0099 ,  G01N35/028 ,  G01N35/1074 ,  G01N2035/00356 ,  G01N2035/0425 ,  G01N2035/0498

摘要： In an automatic testing apparatus comprising, a specimen holder area adapted to hold thereon a specimen substrate for receiving therein a specimen, a reagent injector adapted to inject a reagent toward the specimen in the specimen substrate on the specimen holder area to mix the specimen with the reagent, a mixture reaction device adapted to hold thereon the specimen substrate including the mixture of the specimen and the reagent within a predetermined circumferential condition during a time period, and a transferring device for transferring the specimen substrate relative to the specimen holder area, the mixture reaction device has a take-in area to which the specimen substrate is transferred from the specimen holder area by the transferring device, and the take-in area is arranged adjacent to the specimen holder area.

摘要翻译： 一种自动检测装置，其特征在于，包括：试样保持区域，其适于在其上容纳有用于容纳试样的试样基板，适于向试样保持体区域的试样基板上的试样注入试剂，将试样与 试剂，混合反应装置，其适于在一段时间内在预定的周向状态下将包含试样和试剂的混合物的试样基板保持在其上，以及用于相对于试样保持器区域传送试样基板的转印装置， 反应装置具有通过转印装置从试样保持体区域将试样基板从其移送到的入口区域，并且导入区域邻近试样保持器区域布置。

公开(公告)号：US06238626B1

公开(公告)日：2001-05-29

申请号：US09289607

申请日：1999-04-12

申请人： Akira Higuchi ,  Eiji Watanabe ,  Naoki Miyazaki ,  Kanji Yahiro ,  Kenichi Kuroda ,  Hideyoshi Kitahara ,  Kenji Ishiyama ,  Takashi Daikoku

发明人： Akira Higuchi ,  Eiji Watanabe ,  Naoki Miyazaki ,  Kanji Yahiro ,  Kenichi Kuroda ,  Hideyoshi Kitahara ,  Kenji Ishiyama ,  Takashi Daikoku

IPC分类号： B01L302

CPC分类号： G01N35/10 ,  B01L3/0275 ,  G01N2035/103 ,  Y10T436/2575

摘要： In a method for distributing liquids, in which a distribution tip attached detachably to the lower end of a distribution nozzle can be replaced at any time necessary, a tip rack having a plurality of unused distribution tips lined up thereon is placed on a fitting stage to have the distribution tips fitted with a distribution nozzles. Then, the existence, or non-existence, of a distribution tip left behind on the tip rack without being attached to a distribution nozzle after the fitting operation is finished is detected by a detection section formed of an interrupting-type light sensor, the targeted place of detection by the light sensor being the lower end of the distribution tip. Under the above-described structure, misfitting of a distribution tip can be detected with a high certainty at an early stage before an operation for sucking/discharging liquids is started.

摘要翻译： 在分配液体的方法中，可以随时更换可分配到分配喷嘴的下端的分配末端，其中具有多个未分配的未分配尖端的末端齿条放置在装配台上 具有配有分配喷嘴的分配头。 然后，通过由中断型光传感器形成的检测部分来检测在装配操作完成后未附着在分配喷嘴上的尖端齿条上留下的分配尖端的存在或不存在，目标 光传感器的检测位置是分配尖端的下端。 在上述结构之前，可以在开始吸取/排出液体的操作之前的早期阶段高精度地检测分配尖端的错配。