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公开(公告)号：US07273714B2
公开(公告)日：2007-09-25
申请号：US11373623
申请日：2006-03-09
Applicant: Ivan C. King , Xu Lin
Inventor： Ivan C. King , Xu Lin
CPC classification number: C12Q1/48 , G01N2333/91245
Abstract: This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional; contacting the sample with an AGT Detector under conditions permitting the binding of AGT and AGTD to produce a signal; and measuring the signal, thereby determining the AGT activity in said sample. This invention provides different uses of this method.
Abstract translation: 本发明提供了一种测定样品中烷基泛酰基转移酶活性的方法，包括以下步骤：将样品置于适当的条件下，使得AGT具有功能; 在允许AGT和AGTD结合产生信号的条件下将样品与AGT检测器接触; 并测量信号，从而确定所述样品中的AGT活性。 本发明提供了该方法的不同用途。
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公开(公告)号：US08026395B1
公开(公告)日：2011-09-27
申请号：US12454997
申请日：2009-05-27
IPC: C07C303/00
CPC classification number: C07C303/40 , C07C311/55
Abstract: The present invention relates to simple, safe, high-yield methods of synthesizing VNP40101M, 1,2-bis(methylsulfonyl)-2-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine, an anti-neoplasia agent. One particularly preferred method uses methyl chloroformamide in a one-pot reaction at elevated temperatures to provide VNP40101M in high yield.
Abstract translation: 本发明涉及合成VNP40101M，1,2-双（甲基磺酰基）-2-（2-氯乙基）-2-（甲基氨基羰基）肼，抗肿瘤剂的简单，安全，高产出的方法。 一种特别优选的方法是在高温下使用甲基氯仿酰胺进行一锅反应，以高产率提供VNP40101M。
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公开(公告)号：US20060205027A1
公开(公告)日：2006-09-14
申请号：US11373623
申请日：2006-03-09
CPC classification number: C12Q1/48 , G01N2333/91245
Abstract: This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional; contacting the sample with an AGT Detector under conditions permitting the binding of AGT and AGTD to produce a signal; and measuring the signal, thereby determining the AGT activity in said sample. This invention provides different uses of this method.
Abstract translation: 本发明提供了一种测定样品中烷基泛酰基转移酶活性的方法，包括以下步骤：将样品置于适当的条件下，使得AGT具有功能; 在允许AGT和AGTD结合产生信号的条件下将样品与AGT检测器接触; 并测量信号，从而确定所述样品中的AGT活性。 本发明提供了该方法的不同用途。
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公开(公告)号：US06458816B1
公开(公告)日：2002-10-01
申请号：US09977659
申请日：2001-10-15
Applicant: Terrence W. Doyle , Srinivasa Karra , Zujin Li , Xu Lin , John Mao , Qi Qiao , Yang Xu
Inventor： Terrence W. Doyle , Srinivasa Karra , Zujin Li , Xu Lin , John Mao , Qi Qiao , Yang Xu
IPC: C07D21302
CPC classification number: C07D213/75 , A61K31/407 , A61K31/44 , A61K31/47 , A61K31/675 , A61K31/70 , A61K31/704 , A61K31/7068 , A61K33/24 , A61K45/06 , A61K47/52 , C07F9/58 , A61K31/195 , A61K2300/00
Abstract: The present invention relates to compounds according to the structure: Where R is H or CH3; R2 is phosphate which can be free acid or salt; R3 is H, F, Cl, Br, I, OCH3, OCF3 , CF3 or a C1-C3 alkyl group; R4 is H, F, Cl, Br, I, OCH3, OCF3 or CF3; and R5 and R6 are each independently H, F, Cl, Br, I, OCH3, OCF3 or CF3, with the proviso that when any two of R3, R4, R5 or R6 are other than H, the other two of R3, R4, R5 or R6 are H which may be used to treat neoplasia, including cancer.
Abstract translation: 本发明涉及以下结构的化合物：其中R是H或CH 3; R 2是可以是游离酸或盐的磷酸酯; R 3是H，F，Cl，Br，I，OCH 3，OCF 3，CF 3或C 1 -C 3 烷基; R 4是H，F，Cl，Br，I，OCH 3，OCF 3或CF 3; R 5和R 6各自独立地为H，F，Cl，Br，I，OCH 3，OCF 3或CF 3，条件是当R 3，R 4，R 5或R 6中的任何两个不同于H时， R5或R6是H，其可以用于治疗包括癌症在内的肿瘤。
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5.发明申请Packet timing method and apparatus of a receiver system for controlling digital TV program start time 审中-公开用于控制数字电视节目开始时间的接收机系统的分组定时方法和装置公开(公告)号：US20050262537A1
公开(公告)日：2005-11-24
申请号：US11141693
申请日：2005-05-31
Applicant: Paul Baran , Xu Lin , John Pickens , Michael Field
Inventor： Paul Baran , Xu Lin , John Pickens , Michael Field
CPC classification number: H04L63/068 , H04L29/06027 , H04L63/10 , H04L65/4084 , H04N7/17318 , H04N21/2318 , H04N21/2326 , H04N21/23406 , H04N21/2347 , H04N21/2362 , H04N21/2365 , H04N21/26606 , H04N21/4347 , H04N21/47202 , H04N21/6405 , H04N21/6587 , H05K1/0275 , H05K1/144 , H05K1/185 , H05K2201/10151
Abstract: A packet timing method and apparatus for use with a system for controlling digital TV program start time. An encoder inserts a program clock reference (PCR) timing field, in at least two intervals in transport packets. A decoder generates a decoder-clock signal from the PCR timing signal, which has the same frequency as an encoder-clock signal used for encoding. In response to the PCR timing field, a rate of consumption of data is synchronized with a rate of production of data, and chroma sub-carrier is synchronized.
Abstract translation: 一种用于控制数字电视节目开始时间的系统的分组定时方法和装置。 编码器在传输分组中以至少两个间隔插入程序时钟参考（PCR）定时字段。 解码器从PCR定时信号产生解码器时钟信号，该定时信号具有与用于编码的编码器 - 时钟信号相同的频率。 响应于PCR定时字段，数据的消耗速率与数据的生成速率同步，并且色度子载波被同步。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20050108763A1
公开(公告)日：2005-05-19
申请号：US10976351
申请日：2004-10-28
Applicant: Paul Baran , Xu Lin , John Pickens , Michael Field
Inventor： Paul Baran , Xu Lin , John Pickens , Michael Field
CPC classification number: H04L63/068 , H04L29/06027 , H04L63/10 , H04L65/4084 , H04N7/17318 , H04N21/2318 , H04N21/2326 , H04N21/23406 , H04N21/2347 , H04N21/2362 , H04N21/2365 , H04N21/26606 , H04N21/4347 , H04N21/47202 , H04N21/6405 , H04N21/6587 , H05K1/0275 , H05K1/144 , H05K1/185 , H05K2201/10151
Abstract: A video system for providing a large number of video streams. The video system includes a video server and dividing means. Storage means, a switch and control means are located at the video server. The video server has a plurality of central-processing units (CPUs). The dividing means divides a plurality of input video-streams entering the video system, and sends the divided plurality of input-video streams, with each divided video stream identified with a separate Ethernet address, to the video server. The storage means stores an input video-stream of the plurality of input video-streams as a stored-video stream. The switch routes an input-video stream of the plurality of input-video streams to the storage means. The control means controls the storage means to replay the stored-video stream and to control portions of the stored-video stream at an appropriate time, and controls the plurality of CPUs at the video server to work in parallel.
Abstract translation: 用于提供大量视频流的视频系统。 视频系统包括视频服务器和分割装置。 存储装置，开关和控制装置位于视频服务器处。 视频服务器具有多个中央处理单元（CPU）。 分割装置分割进入视频系统的多个输入视频流，并将划分的多个输入视频流与每个分离的视频流以单独的以太网地址标识，发送给视频服务器。 存储装置将多个输入视频流的输入视频流存储为存储视频流。 交换机将多个输入视频流的输入视频流路由到存储装置。 控制装置控制存储装置重放所存储的视频流并在适当的时间控制存储视频流的部分，并且控制视频服务器上的多个CPU并行工作。
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公开(公告)号：US20050043244A1
公开(公告)日：2005-02-24
申请号：US10950890
申请日：2004-09-27
Applicant: Xu Lin , Terrence Doyle , Ivan King
Inventor： Xu Lin , Terrence Doyle , Ivan King
IPC: A61K38/04 , A61K38/16 , C07C311/55 , C07F9/12 , A61K31/175 , A61K31/195 , A61K31/277 , A61K38/05 , A61K38/06 , A61K38/08 , A61K38/10
CPC classification number: C07C311/55 , A61K38/04 , A61K38/16 , C07F9/12
Abstract: The present invention relates to compounds according to the structure (I): Where R is —CH3 or —CH2CH2Cl; R′ is C1-C7 alkyl or —CH2CH2Cl; R2 or R4 is OP03H2, N02, OCO(Glu-OH), NHCO(Glu-OH), NHR7 and unassigned groups of R2, R3, R4, R5 and R6 are, independently, H, F, Cl, Br, I, OH, OP03H2, OCH3, CF3, OCF3, NO2, CN, SO2CH3, SO2CF3, COCH3, COOCH3, SCH3, SFs, NH2, NHR7, N(CH3)2, OPO3H2, or a C1-C7 alkyl group with the proviso that when any two of unassigned groups of R2, R3, R4, R5 or R6 are other than H, the other two of unassigned groups of R2, R3, R4, R5 or R6 are H. R7 is H or polyglutamyl as described. Phosphoric acid and glutamic acid can be a free acid or pharmaceutically acceptable salt thereof.
Abstract translation: 本发明涉及根据结构（I）的化合物：其中R是-CH 3或-CH 2 CH 2 Cl; R'是C 1 -C 7烷基或-CH 2 CH 2 Cl; R2或R4是OP03H2，N02，OCO（Glu-OH），NHCO（Glu-OH），NHR7，R2，R3，R4，R5和R6的未分配基团独立地是H，F，Cl，Br， OH，OPO 3 H 2，OCH 3，CF 3，OCF 3，NO 2，CN，SO 2 CH 3，SO 2 CF 3，COCH 3，COOCH 3，SCH 3，SF，NH 2，NHR 7，N（CH 3）2，OPO 3 H 2或C 1 -C 7烷基， R2，R3，R4，R5或R6的任何两个未分配的基团不是H，R2，R3，R4，R5或R6的另外两个未分配的基团是H.R 7是H或所述的聚谷氨酰基。 磷酸和谷氨酸可以是游离酸或其药学上可接受的盐。
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公开(公告)号：US20080299556A2
公开(公告)日：2008-12-04
申请号：US11856909
申请日：2007-09-18
IPC: C12Q1/68 , C07D473/30 , G01N33/53 , C07D473/34
CPC classification number: C12Q1/48 , G01N2333/91245
Abstract: This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional; contacting the sample with an AGT Detector under conditions permitting the binding of AGT and AGTD to produce a signal; and measuring the signal, thereby determining the AGT activity in said sample. This invention provides different uses of this method.
Abstract translation: 本发明提供了一种测定样品中烷基泛酰基转移酶活性的方法，包括以下步骤：将样品置于适当的条件下，使得AGT具有功能; 在允许AGT和AGTD结合产生信号的条件下将样品与AGT检测器接触; 并测量信号，从而确定所述样品中的AGT活性。 本发明提供了该方法的不同用途。
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9.发明申请Method and apparatus of an input unit of a method and apparatus for controlling digital TV program start time 审中-公开用于控制数字电视节目开始时间的方法和装置的输入单元的方法和装置公开(公告)号：US20050198679A1
公开(公告)日：2005-09-08
申请号：US11098786
申请日：2005-04-04
Applicant: Paul Baran , Xu Lin , John Pickens , Michael Field
Inventor： Paul Baran , Xu Lin , John Pickens , Michael Field
IPC: H04L29/06 , H04N7/173 , H05K1/02 , H05K1/14 , H05K1/18 , G06F3/00 , G06F13/00 , H04N5/445 , H04N7/16 , H04N7/20
CPC classification number: H04L63/068 , H04L29/06027 , H04L63/10 , H04L65/4084 , H04N7/17318 , H04N21/2318 , H04N21/2326 , H04N21/23406 , H04N21/2347 , H04N21/2362 , H04N21/2365 , H04N21/26606 , H04N21/4347 , H04N21/47202 , H04N21/6405 , H04N21/6587 , H05K1/0275 , H05K1/144 , H05K1/185 , H05K2201/10151
Abstract: A method of an input unit of a method and apparatus for controlling digital TV program start time. The input unit and method of the input unit receive digital channels from multiple sources, as a plurality of digital-transport streams, respectively. Each digital-transport stream has a multiplicity of transport packets. The input unit and method time-stamp each of the received transport packets of the multiplicity of transport packets, thereby generating a plurality of time-stamped packets, and aggregate the plurality of time-stamped packets, and scramble the aggregated plurality of time-stamped packets. The scrambled-aggregated plurality of time-stamped packets are encapsulated.
Abstract translation: 一种用于控制数字电视节目开始时间的方法和装置的输入单元的方法。 输入单元的输入单元和方法分别从多个源接收数字信道作为多个数字传输流。 每个数字传输流具有多个传输分组。 输入单元和方法对多个传输分组的所接收的传输分组中的每一个进行时间标记，从而生成多个时间戳分组，并且聚合多个时间戳分组，并且将聚合的多个时间戳 数据包 被加密的多个时间戳的分组被封装。
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公开(公告)号：US20080076132A1
公开(公告)日：2008-03-27
申请号：US11856909
申请日：2007-09-18
IPC: C12Q1/68 , C07D473/30 , G01N33/53 , C07D473/34
CPC classification number: C12Q1/48 , G01N2333/91245
Abstract: This invention provides a method to determine alkylguanyltransferase activity in a sample, comprising steps of placing the sample in an appropriate condition so that the AGT is functional; contacting the sample with an AGT Detector under conditions permitting the binding of AGT and AGTD to produce a signal; and measuring the signal, thereby determining the AGT activity in said sample. This invention provides different uses of this method.
Abstract translation: 本发明提供了一种测定样品中烷基泛酰基转移酶活性的方法，包括以下步骤：将样品置于适当的条件下，使得AGT具有功能; 在允许AGT和AGTD结合产生信号的条件下将样品与AGT检测器接触; 并测量信号，从而确定所述样品中的AGT活性。 本发明提供了该方法的不同用途。
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