摘要:
Novel quaternary ammonium compounds of the formula and any stereoisomers thereof, wherein R1, R2 and R3 independently represent C1-C6 alkyl, optionally substituted with phenyl or hydroxyl, or both, and wherein any two of R1, R2 and R3 may form a ring together with the quaternary ammonium nitrogen; R4 represents —H, —CH3, or —CO—R4-1, wherein R4-1 represents —(C1-C4 alkyl), —(C1-C4 alkoxy), or —NR4-2R4-3, wherein R4-2 and R4-3 independently represent —H or —(C1-C4 alkyl); R5, R6 and R7 independently represent —H, —OCH3, —OH, —CONH2, —SO2NH2, —F, —Cl, —Br, —I, —CF3, or —(C1-C4 alkyl), optionally substituted with one or two —OH, —(C1-C4 alkoxy), —COOH, or —CO—O—(C1-C3 alkyl); and X− represents an anion of a pharmaceutically acceptable acid, the compounds for use as medicaments, use of the compounds for the manufacture of specific medicaments, and pharmaceutical compositions comprising the compounds. The present invention also concerns a method of treatment involving administration of the compounds.
摘要:
The compound 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-(trifluoromethyl) phenol may be used to prepare the compound (3R)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-N,N-diisopropyl-N-methyl-3-phenylpropan-1-aminium bromide by reaction with methyl bromide.
摘要:
A method for treating asthma in a patient using an agent selected from the group consisting of: (a) an antibody capable of binding to ELAM-1; (b) a fragment of the antibody (a), the fragment being capable of binding to ELAM-1; (c) ELAM-1, being substantially free of natural contaminants; (d) a functional derivative of ELAM-1; (e) an antibody capable of binding to an ELAM-1 receptor; (f) a fragment of the antibody (e), the fragment being capable of binding to an ELAM-1 receptor; (g) an ELAM-1 receptor, being substantially free of natural contaminants; and . (h) a functional derivative of an ELAM-1 receptor.
摘要:
The present invention relates to the use of intercellular adhesion molecule-1 (ICAM-1) or fragments thereof, anti-CD18 antibodies or fragments thereof, and members of the CD18 family of proteins or fragments thereof in the treatment of asthma.
摘要:
The present invention provides a method of reducing the severity of asthma. Specifically, the present invention discloses that anti-adhesion antibodies, such as anti-ICAM-1 or anti-CD18 family member antibodies, when administered to a mammal, are capable of decreasing the hyperresponsive reaction associated with an asthmatic response.
摘要:
A method for inhibiting pulmonary oxygen toxicity in a patient requiring elevated levels of inhaled oxygen, by prophylactic administration of certain adhesion molecules and antibodies thereto.