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公开(公告)号：US20080207586A1
公开(公告)日：2008-08-28
申请号：US12012932
申请日：2008-02-05
IPC分类号： A61K31/407 , C07D487/04 , A61P31/00
CPC分类号： C07D477/20 , C07B2200/13
摘要： A novel crystal of a pyrrolidylthiocarbapenem derivative having excellent stability is provided. According to the present invention, a crystal of (+)-(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3[[(3S,5S)-5-(sulfamoylaminomethyl)pyrrolidin-3-yl]thio]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid having a diffraction pattern in powder X-ray diffraction preferably having main peaks at diffraction angles (2θ)=13.04, 14.98, 15.88, 16.62, 20.62, 21.06, 22.18, 23.90, 26.08, 28.22 and 28.98 (degrees) is provided.
摘要翻译： 提供了具有优异稳定性的吡咯烷基硫代碳青霉烯衍生物的新型结晶。 根据本发明，（+） - （4R，5S，6S）-6 - [（1R）-1-羟乙基] -4-甲基-7-氧代-3 [[（3S，5S） 在粉末X射线衍射中具有衍射图案的5-（氨磺酰氨基甲基）吡咯烷-3-基]硫] -1-氮杂双环[3.2.0]庚-2-烯-2-羧酸优选在衍射角 2θ）= 13.04,14.98,15.C，16.62,20.62,21.06,22.18,23.90,26.08,28.22和28.98（度）。
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公开(公告)号：US20130059831A1
公开(公告)日：2013-03-07
申请号：US13585611
申请日：2012-08-14
IPC分类号： A61K31/407 , A61P31/00 , C07D487/04
CPC分类号： C07D477/20 , C07B2200/13
摘要： Novel crystals of a pyrrolidylthiocarbapenem derivative having excellent stability is provided. According to the present invention, a crystal of (+)-(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3[[(3S,5S)-5-(sulfamoylaminomethyl)pyrrolidin-3-yl]thio]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid having a diffraction pattern in powder X-ray diffraction having main peaks at diffraction angles (2θ) of about 6.62, 13.04, 15.44, 16.58, 17.64, 20.88, 23.26, 25.02 and 25.52 (degrees) are provided.
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公开(公告)号：US20070060562A1
公开(公告)日：2007-03-15
申请号：US11595348
申请日：2006-11-10
IPC分类号： C07D487/04 , A61K31/407
CPC分类号： C07D477/20 , C07B2200/13
摘要： A novel crystal of a pyrrolidylthiocarbapenem derivative having excellent stability is provided. According to the present invention, a crystal of (+)-(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3 [[(3S,5S)-5-(sulfamoylaminomethyl)pyrrolidin-3-yl]thio]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid having a diffraction pattern in powder X-ray diffraction preferably having main peaks at diffraction angles (2θ)=13.04, 14.98, 15.88, 16.62, 20.62, 21.06, 22.18, 23.90, 26.08, 28.22 and 28.98 (degrees) is provided.
摘要翻译： 提供了具有优异稳定性的吡咯烷基硫代碳青霉烯衍生物的新型结晶。 根据本发明，（+） - （4R，5S，6S）-6 - [（1R）-1-羟乙基] -4-甲基-7-氧代-3 [[（3S，5S） 在粉末X射线衍射中具有衍射图案的5-（氨磺酰氨基甲基）吡咯烷-3-基]硫] -1-氮杂双环[3.2.0]庚-2-烯-2-羧酸优选在衍射角 2θ）= 13.04,14.98,15.C，16.62,20.62,21.06,22.18,23.90,26.08,28.22和28.98（度）。
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公开(公告)号：US08247402B2
公开(公告)日：2012-08-21
申请号：US12012932
申请日：2008-02-05
IPC分类号： C07D477/20 , A61K31/407 , A61P31/04
CPC分类号： C07D477/20 , C07B2200/13
摘要： Novel crystals of a pyrrolidylthiocarbapenem derivative having excellent stability is provided. According to the present invention, a crystal of (+)-(4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3[[(3S,5S)-5-(sulfamoylaminomethyl)p yrrolidin-3-yl]thio]-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid having a diffraction pattern in powder X-ray diffraction having main peaks at diffraction angles (2θ) of about 13.04, 14.98, 15.88, 16.62, 20.62, 21.06, 22.18, 23.90, 26.08, 28.22 and 28.98 (degrees) and a crystal of said compound having a diffraction pattern in powder X-ray diffraction having main peaks at diffraction angles (2θ) of about 6.62, 13.04, 15.44, 16.58, 17.64, 20.88, 23.26, 25.02 and 25.52 (degrees) are provided.
摘要翻译： 提供具有优异稳定性的吡咯烷基硫代碳青霉烯衍生物的新型晶体。 根据本发明，（+） - （4R，5S，6S）-6 - [（1R）-1-羟乙基] -4-甲基-7-氧代-3 [[（3S，5S） 具有衍射图案的5-（氨磺酰氨基甲基）吡咯烷-3-基]硫] -1-氮杂双环[3.2.0]庚-2-烯-2-羧酸，其衍射图在粉末X射线衍射中具有衍射角 2），约13.04,14.98,15.C，16.62,20.62,21.06,22.18,29.90,26.08,28.22和28.98（度），所述化合物的晶体在粉末X射线衍射中具有在衍射峰上具有主峰的衍射图案 提供约6.62,13.04,15.44,16.58,17.64,20.88,23.26,25.02和25.52（度）的角度（2＆amp;）。
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公开(公告)号：US07164805B2
公开(公告)日：2007-01-16
申请号：US10108332
申请日：2002-03-29
申请人： Masayuki Takahira
发明人： Masayuki Takahira
CPC分类号： G06T5/004 , G06K15/00 , G06K15/027 , G06K15/1848 , G06K15/186 , H04N1/409
摘要： An image processing method and apparatus enhancing sharpness of an image while suppressing enhancement of noise components. Image data is separated into frequency components, and an evaluation value for evaluating the level of an image to be enhanced is calculated for each pixel. A gain for an intermediate/high frequency component is set in accordance with the evaluation value, and multiplied by the intermediate/high frequency component, and the frequency components are synthesized. Test images, each having a density which is different from the other but constant over the test image, are prepared and an evaluation value is obtained from each of the test images as an evaluation correction value. The evaluation value of the image for processing is corrected by subtracting the evaluation correction value corresponding to the density of each pixel from the evaluation value of the image data to be processed for each pixel.
摘要翻译： 一种在抑制噪声分量增强的同时增强图像的清晰度的图像处理方法和装置。 图像数据被分成频率分量，并且针对每个像素计算用于评估要增强的图像的电平的评估值。 根据评价值设定中高频分量的增益，乘以中高频分量，合成频率分量。 准备测试图像，每个测试图像的密度与测试图像之间的密度不同但是恒定，并且从每个测试图像获得评估值作为评估校正值。 通过从针对每个像素的要处理的图像数据的评估值中减去与每个像素的浓度相对应的评估校正值来校正处理图像的评估值。
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公开(公告)号：US08439823B2
公开(公告)日：2013-05-14
申请号：US12622818
申请日：2009-11-20
申请人： Masahiro Kubo , Makoto Kagaya , Masayuki Takahira , Masayuki Kuramoto , Shuichi Ishii , Ryo Takahashi
发明人： Masahiro Kubo , Makoto Kagaya , Masayuki Takahira , Masayuki Kuramoto , Shuichi Ishii , Ryo Takahashi
IPC分类号： A61B1/04
CPC分类号： A61B1/00188 , A61B1/00009 , A61B1/00096 , A61B1/045 , A61B5/0084
摘要： An imaging mode is automatically switched based on the kind of a subject. The spatial frequency of an endoscopic image obtained by imaging the subject is detected. Further, judgment is made, based on the distribution of the spatial frequency, as to whether the endoscopic image was obtained by performing close-up imaging on the subject. The condition of imaging is switched based on the result of judgment as to whether the image was obtained by close-up imaging or distant-view imaging.
摘要翻译： 成像模式根据被摄体的种类自动切换。 检测通过对被检体成像而获得的内窥镜图像的空间频率。 此外，基于空间频率的分布，判断是否通过对被摄体进行特写成像来获得内窥镜图像。 基于通过特写成像或远视成像获得图像的判断结果来切换成像条件。
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公开(公告)号：US20100097454A1
公开(公告)日：2010-04-22
申请号：US12603187
申请日：2009-10-21
申请人： Masahiro KUBO , Yasunori Ohta , Masayuki Takahira , Naoto Kinjo
发明人： Masahiro KUBO , Yasunori Ohta , Masayuki Takahira , Naoto Kinjo
CPC分类号： A61B1/00188 , A61B1/063 , A61B1/0638 , A61B1/0646 , G06T7/0012 , G06T7/13 , G06T7/48 , G06T2207/10068 , G06T2207/10152 , G06T2207/30028 , G06T2207/30092 , H04N5/232 , H04N5/23245 , H04N2005/2255 , H04N2209/044
摘要： An endoscope image is obtained by imaging a subject with a scope. Then, an edge portion of the endoscope image is extracted and a complexity degree of the edge portion is detected. Thereafter, a determination is made as to whether the endoscope image is an image obtained through near view imaging or distant view imaging according to the complexity degree and an imaging condition is changed according to the determined near view imaging or distant view imaging.
摘要翻译： 通过对被摄体进行成像来获得内窥镜图像。 然后，提取内窥镜图像的边缘部分，并检测边缘部分的复杂程度。 此后，确定内窥镜图像是否是根据复杂程度通过近视成像或远视成像获得的图像，并且根据确定的近视图像或远视成像来改变成像条件。
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8.发明申请公开(公告)号：US20090071233A1
公开(公告)日：2009-03-19
申请号：US12216066
申请日：2008-06-27
申请人： Masayuki Takahira , Yozo Ishihara , Ikunobu Sumida
发明人： Masayuki Takahira , Yozo Ishihara , Ikunobu Sumida
CPC分类号： G01N30/34 , G01N2030/345
摘要： The purpose of the present invention is to provide a method which makes it possible to analyze more easily the concentration of glue in an electrolyte solution, while surpressing the degradation of glue during the analysis. There is provided a method for analyzing the concentration of glue contained in an electrolyte solution containing the electrolyte components by using high performance liquid chromatography, characterized in that said method comprises a step wherein an electrolyte solution is added into the eluent pH of which has been adjusted equal to or less than 5 by adding acid to an aqueous solution of phosphate of alkaline metal or alkaline earth metal, a step wherein the eluent into which the electrolyte solution has been added is passed through a separation column the exclusion limit molecular weight of which is 4000-6000 for separating the glue and electrolyte components, and a step wherein the separated glue is detected by a detector.
摘要翻译： 本发明的目的是提供一种能够在分析期间抑制胶水劣化的同时更容易地分析电解质溶液中的胶的浓度的方法。 提供了一种通过使用高效液相色谱分析含有电解质成分的电解质溶液中所含的胶的浓度的方法，其特征在于所述方法包括将电解质溶液加入已经调节的pH的洗脱液中 通过向碱金属或碱土金属的磷酸盐水溶液中加入酸等于或小于5的步骤，将其中加入电解质溶液的洗脱液通过其排除极限分子量为 4000-6000用于分离胶和电解质组分，以及其中分离的胶被检测器检测的步骤。
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公开(公告)号：US08553075B2
公开(公告)日：2013-10-08
申请号：US12603187
申请日：2009-10-21
申请人： Masahiro Kubo , Yasunori Ohta , Masayuki Takahira , Naoto Kinjo
发明人： Masahiro Kubo , Yasunori Ohta , Masayuki Takahira , Naoto Kinjo
CPC分类号： A61B1/00188 , A61B1/063 , A61B1/0638 , A61B1/0646 , G06T7/0012 , G06T7/13 , G06T7/48 , G06T2207/10068 , G06T2207/10152 , G06T2207/30028 , G06T2207/30092 , H04N5/232 , H04N5/23245 , H04N2005/2255 , H04N2209/044
摘要： An endoscope image is obtained by imaging a subject with a scope. Then, an edge portion of the endoscope image is extracted and a complexity degree of the edge portion is detected. Thereafter, a determination is made as to whether the endoscope image is an image obtained through near view imaging or distant view imaging according to the complexity degree and an imaging condition is changed according to the determined near view imaging or distant view imaging.
摘要翻译： 通过对被摄体进行成像来获得内窥镜图像。 然后，提取内窥镜图像的边缘部分，并检测边缘部分的复杂程度。 此后，确定内窥镜图像是否是根据复杂程度通过近视成像或远视成像获得的图像，并且根据确定的近视图像或远视成像来改变成像条件。
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公开(公告)号：US20100141747A1
公开(公告)日：2010-06-10
申请号：US12633559
申请日：2009-12-08
申请人： Masahiro KUBO , Makoto Kagaya , Masayuki Takahira , Masayuki Kuramoto , Shuichi Ishii , Ryo Takahashi
发明人： Masahiro KUBO , Makoto Kagaya , Masayuki Takahira , Masayuki Kuramoto , Shuichi Ishii , Ryo Takahashi
IPC分类号： A61B1/04
CPC分类号： A61B1/045 , A61B1/00009 , A61B1/063 , A61B1/0638 , A61B1/0646 , A61B5/0084
摘要： A narrow-band observation image and a spectral estimation image are automatically switched based on the type of a subject. In an endoscopic image obtained by a scope, judgment is made as to whether the endoscopic image was obtained by close-up imaging or by distant-view imaging. When it is judged that the endoscopic image was obtained by distant-view imaging, white light is output from a light source unit and a spectral estimation image is output. When it is judged that the endoscopic image was obtained by close-up imaging, narrow-band light is output from the light source unit and a narrow-band observation image that has been obtained when the narrow-band light was output is output.
摘要翻译： 基于被摄体的种类自动切换窄带观察图像和谱估计图像。 在通过范围获得的内窥镜图像中，判断通过特写成像或远视成像获得内窥镜图像。 当判断为通过远摄成像获得内窥镜图像时，从光源单元输出白光，并输出光谱估计图像。 当判断为通过特写成像获得内窥镜图像时，从光源单元输出窄带光，并输出在输出窄带光时获得的窄带观察图像。
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