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    Rapamycin metabolites
    3.
    发明授权
    Rapamycin metabolites 失效
    雷帕霉素代谢物

    公开(公告)号：US5776943A

    公开(公告)日：1998-07-07

    申请号：US699505

    申请日：1991-05-14

    申请人： Uwe Christians ,  Karl F. Sewing ,  Martin Sattler

    发明人： Uwe Christians ,  Karl F. Sewing ,  Martin Sattler

    IPC分类号： A61K31/435 ,  A61P29/00 ,  A61P31/04 ,  A61P37/06 ,  C07D498/18 ,  C12P17/18 ,  A61K31/44 ,  C07D491/00

    CPC分类号： C07D498/18 ,  C12P17/188

    摘要： This invention provides metabolites of rapamycin, the first of which is 41-O-desmethyl rapamycin, having a deprotonated molecular ion detected at a mass to charge ratio of 899, and a characteristic desorption chemical ionization mass spectroscopic fragmentation pattern comprising ions detected at a mass to charge ratio of 591, 569, 559, 543, 529, 421, and 308. A second compound of this invention is a hydroxylated metabolite of rapamycin having a deprotonated molecular ion detected at a mass to charge ratio of 928, and a characteristic direct chemical ionization mass spectroscopic fragmentation pattern comprising ions detected at a mass to charge ratio of 607, 571, 545, 513, 322, 290, and 241 amu. The compounds of this invention, by virtue of their immunosuppressive activity are useful in treating transplantation rejection, host vs. graft disease, autoimmune diseases and diseases of inflammation; by virtue of their antitumor activity are useful in treating solid tumors; and by virtue of their antifungal activity are useful in treating fungal infections.

    摘要翻译： 本发明提供了雷帕霉素的代谢物，其中第一种是41-O-去甲基雷帕霉素，其具有以质量与电荷比为899检测到的去质子化分子离子，以及特征解吸化学电离质谱分析图谱，其包含在质量 本发明的第二化合物是雷帕霉素的羟基化代谢物，其具有以质量与电荷比为928检测到去质子化的分子离子，并且特征直接 化学电离质谱碎片图案包括以质荷比检测到的离子为607,571,545,513,322,290和241amu的离子。 本发明化合物由于其免疫抑制活性可用于治疗移植排斥反应，宿主与移植物疾病，自身免疫疾病和炎症疾病; 由于其抗肿瘤活性可用于治疗实体瘤; 并且由于其抗真菌活性可用于治疗真菌感染。

    Fuel cell system and method of regenerating a filter element in a fuel cell system
    6.
    发明授权
    Fuel cell system and method of regenerating a filter element in a fuel cell system 失效
    燃料电池系统和在燃料电池系统中再生过滤元件的方法

    公开(公告)号：US06403243B1

    公开(公告)日：2002-06-11

    申请号：US09539006

    申请日：2000-03-30

    申请人： Wolfgang Herdeg ,  Holger Klos ,  Martin Sattler ,  Franz Reichenbach ,  Hans-Dieter Wilhelm ,  Jürgen Habrich ,  Karl Eck ,  Markus Keutz ,  Thomas Zapp

    发明人： Wolfgang Herdeg ,  Holger Klos ,  Martin Sattler ,  Franz Reichenbach ,  Hans-Dieter Wilhelm ,  Jürgen Habrich ,  Karl Eck ,  Markus Keutz ,  Thomas Zapp

    IPC分类号： H01M800

    CPC分类号： F02M25/08 ,  H01M8/04022 ,  H01M8/0612 ,  H01M2250/20 ,  Y02T90/32

    摘要： A fuel cell system which has a fuel cell with a supply line and a discharge line for a fuel as well as a supply line and a discharge line for an oxidizing agent. Also provided is a fuel tank which contains, for example, benzene or methanol for producing the fuel for the fuel cell. To avoid the release of hydrocarbons from the fuel contained in the tank, a filter element, for example an active carbon filter, is connected to the fuel tank. To be able to regenerate the filter element, the filter element is connected to the discharge line for the oxidizing agent and/or the discharge line for the fuel. The filter element is regenerated by the flow of exhaust gas from the fuel cell. The filter element is preferably connected via a connecting line to a burner, with the result that the hydrocarbons taken up by the flow of exhaust gas can be burned in the burner. Furthermore, by designing the fuel cell system appropriately, a leakage diagnosis can also be performed in the fuel tank.

    摘要翻译： 一种具有燃料电池的燃料电池系统，其具有供给线和用于燃料的排出管线以及用于氧化剂的供应管线和排出管线。 还提供了一种燃料箱，其包含例如用于生产用于燃料电池的燃料的苯或甲醇。 为了避免碳氢化合物从容纳在罐中的燃料中释放，过滤元件例如活性炭过滤器连接到燃料箱。 为了能够再生过滤元件，过滤元件连接到用于燃料的氧化剂和/或排出管线的排出管线。 过滤元件通过来自燃料电池的废气流再生。 过滤元件优选通过连接管线连接到燃烧器，结果是能够在燃烧器中燃烧排出气体的碳氢化合物。 此外，通过适当地设计燃料电池系统，也可以在燃料箱中进行泄漏诊断。

    Fuel tank
    7.
    发明授权
    Fuel tank 失效
    油箱

    公开(公告)号：US06610433B1

    公开(公告)日：2003-08-26

    申请号：US09528666

    申请日：2000-03-20

    申请人： Wolfgang Herdeg ,  Holger Klos ,  Martin Sattler ,  Hans-Dieter Wilhelm ,  Jürgen Habrich ,  Karl Eck ,  Thomas Zapp ,  Markus Keutz

    发明人： Wolfgang Herdeg ,  Holger Klos ,  Martin Sattler ,  Hans-Dieter Wilhelm ,  Jürgen Habrich ,  Karl Eck ,  Thomas Zapp ,  Markus Keutz

    IPC分类号： H01M802

    CPC分类号： H01M8/04208

    摘要： A fuel tank, in particular for fuel-cell systems, which can feed fuel into a system via a mechanism without a pump or the like. This is achieved by a fuel tank with a fuel cavity of variable size and a mechanism for compressing the fuel cavity. The fuel cavity is preferably bounded by a cylindrical inner wall of the fuel tank, by a circular end surface of the fuel tank and by a circular, displaceable intermediate wall. The intermediate wall is forced essentially in the direction of the fuel cavity by a spring and has a form fit with the cylindrical inner wall. A feed device and a discharge device allow incorporation in a fuel line. The system also includes a control device and a method for this fuel container, which is thus enabled to have the following operating states: A. fuel-cell system is switched on: discharge valve open, feed valve closed; B. fuel-cell system is in operation: discharge valve open, feed valve open; C. fuel-cell system is switched off: discharge valve closed, feed valve open; and D. fuel-cell system is off, fuel cavity is full: discharge valve closed, feed valve closed.

    摘要翻译： 特别是用于燃料电池系统的燃料箱，其可以通过没有泵等的机构将燃料供给到系统中。 这通过具有可变尺寸的燃料腔的燃料箱和用于压缩燃料腔的机构来实现。 燃料腔优选地由燃料箱的圆柱形内壁，燃料箱的圆形端面和圆形可位移的中间壁限定。 中间壁通过弹簧基本上在燃料腔的方向上被迫动并且具有与圆柱形内壁配合的形式。 进料装置和排出装置允许加入燃料管线。 该系统还包括用于该燃料容器的控制装置和方法，其能够具有以下操作状态：A.燃料电池系统被接通：排出阀打开，供给阀关闭; B.燃料电池系统正在运行：排气阀打开，进料阀打开; C.燃料电池系统关闭：排放阀关闭，进料阀打开; 和D.燃料电池系统关闭，燃油腔已满：排气阀关闭，进料阀关闭。