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公开(公告)号：US07375227B2
公开(公告)日：2008-05-20
申请号：US10501054
申请日：2002-12-02
申请人： Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Jörg Velker , Thomas Weller
发明人： Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Jörg Velker , Thomas Weller
IPC分类号： C07D215/38 , C07D215/44
CPC分类号： C07D471/04 , C07D401/12 , C07D401/14
摘要： The invention relates to novel 1-pyridin-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.
摘要翻译： 本发明涉及新颖的1-吡啶-4-基脲衍生物及其相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为神经激素拮抗剂的用途的相关方面。
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2.发明授权1,2,3,4-Tetrahydroisoquinolines derivatives as urotensin II receptor antagonists 失效1,2,3,4-四氢异喹啉衍生物作为尿素转运蛋白II受体拮抗剂公开(公告)号：US06815451B2
公开(公告)日：2004-11-09
申请号：US10471724
申请日：2003-09-15
申请人： Jörg Velker , Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Thomas Weller
发明人： Jörg Velker , Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Thomas Weller
IPC分类号： C07D40312
CPC分类号： C07D401/12 , C07D405/14 , C07D471/04 , C07D491/04
摘要： The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists especially urotensin II antagonists.
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公开(公告)号：US20060211707A1
公开(公告)日：2006-09-21
申请号：US10555429
申请日：2004-05-04
申请人： Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Jorg Velker , Thomas Weller
发明人： Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Jorg Velker , Thomas Weller
IPC分类号： A61K31/496 , C07D403/02
CPC分类号： C07D215/42 , C07D401/12
摘要： The invention relates to novel piperazine derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.
摘要翻译： 本发明涉及新型哌嗪衍生物及其相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为神经激素拮抗剂的用途的相关方面。
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4.发明申请4-(Piperidyl-and pyrrolidyl-alkyl-ureido)-quinolines as urotensin II receptor antagonists 失效4-（哌啶基和吡咯烷基 - 烷基 - 脲基） - 喹啉作为尿素转运蛋白II受体拮抗剂公开(公告)号：US20050043535A1
公开(公告)日：2005-02-24
申请号：US10501054
申请日：2002-12-02
申请人： Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Jorg Velker , Thomas Weller
发明人： Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Jorg Velker , Thomas Weller
IPC分类号： A61K31/4709 , A61P9/02 , C07D20060101 , C07D401/12 , C07D401/14 , C07D471/04 , C07D471/02 , C07D41/02
CPC分类号： C07D471/04 , C07D401/12 , C07D401/14
摘要： The invention relates to novel 1-pyridin-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.
摘要翻译： 本发明涉及新颖的1-吡啶-4-基脲衍生物及其相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为神经激素拮抗剂的用途的相关方面。
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公开(公告)号：US20070010516A1
公开(公告)日：2007-01-11
申请号：US10556029
申请日：2004-05-04
申请人： Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Jorg Velker , Thomas Weller
发明人： Hamed Aissaoui , Christoph Binkert , Martine Clozel , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Jorg Velker , Thomas Weller
IPC分类号： A61K31/5377 , A61K31/4709 , A61K31/4545 , C07D413/14 , C07D401/02
CPC分类号： C07D401/12 , C07D401/14
摘要： The invention relates to novel piperidine derivatives and related compounds of General Formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists, in particular their use as urotensin II antagonists.
摘要翻译： 本发明涉及通式I的新型哌啶衍生物和相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为神经激素拮抗剂的用途的相关方面，特别是其用作尿路动脉蛋白肽II拮抗剂。
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公开(公告)号：US20060094716A1
公开(公告)日：2006-05-04
申请号：US10528043
申请日：2003-09-12
申请人： Hamed Aissaoui , Christoph Binkert , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Thomas Weller , Jorg Welker , Martine Clozel
发明人： Hamed Aissaoui , Christoph Binkert , Boris Mathys , Claus Mueller , Oliver Nayler , Michael Scherz , Thomas Weller , Jorg Welker , Martine Clozel
IPC分类号： A61K31/5377 , A61K31/4745 , A61K31/4709 , A61K31/4545 , C07D413/02 , C07D401/02 , C07D471/02
CPC分类号： C07D401/12
摘要： The invention relates to novel 1-pyridin-4-yl urea derivatives and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as neurohormonal antagonists.
摘要翻译： 本发明涉及新颖的1-吡啶-4-基脲衍生物及其相关化合物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为神经激素拮抗剂的用途的相关方面。
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公开(公告)号：US20070244156A1
公开(公告)日：2007-10-18
申请号：US11756008
申请日：2007-05-31
申请人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
发明人： Hamed Aissaoui , Martine Clozel , Walter Fischli , Ralf Koberstein , Thierry Sifferlen , Thomas Weller
IPC分类号： A61K31/18 , A61K31/4184 , A61K31/44 , A61K31/473
CPC分类号： C07C311/21 , A61K31/18 , A61K31/4184 , A61K31/44 , A61K31/473 , C07C311/13 , C07C311/20 , C07C311/29 , C07C2601/02 , C07C2601/14 , C07D207/323 , C07D209/14 , C07D213/40 , C07D213/53 , C07D213/71 , C07D213/74 , C07D213/75 , C07D215/12 , C07D215/36 , C07D215/38 , C07D217/02 , C07D231/56 , C07D233/64 , C07D277/28 , C07D401/12 , C07D401/14 , C07D417/12
摘要： The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及新型磺酰基氨基 - 乙酸衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备这些化合物的方法，包含一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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公开(公告)号：US20070191424A1
公开(公告)日：2007-08-16
申请号：US10598449
申请日：2005-02-23
IPC分类号： A61K31/4709 , A61K31/47 , C07D401/02
CPC分类号： C07D217/18 , C07D401/06
摘要： The invention relates to novel 1,2,3,4-tetrahydroisoquinoline derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, phannaceutical compositions containing one or more of those compounds and methods of treatment comprising administration of said compounds to a mammal.
摘要翻译： 本发明涉及新型1,2,3,4-四氢异喹啉衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物和包括向哺乳动物施用所述化合物的治疗方法的相关方面。
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9.发明授权Benzazepines and related heterocyclic derivatives which are useful as orexin receptor antagonists 失效苯并氮杂类和相关杂环衍生物，可用作食欲素受体拮抗剂公开(公告)号：US07192950B2
公开(公告)日：2007-03-20
申请号：US10450420
申请日：2001-12-19
申请人： Hamed Aissaoui , Martine Clozel , Thomas Weller , Ralf Koberstein , Thierry Sifferlen , Walter Fischli
发明人： Hamed Aissaoui , Martine Clozel , Thomas Weller , Ralf Koberstein , Thierry Sifferlen , Walter Fischli
IPC分类号： A61P3/04 , A61K31/55 , C07D223/16
CPC分类号： C07D223/16 , A61K31/55 , C07D243/14 , C07D267/14 , C07D281/10 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The invention relates to novel benzazepines and related heterocyclic derivatives (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
摘要翻译： 本发明涉及新的苯并氮杂和相关杂环衍生物（I）及其作为药物组合物制备中的活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。
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公开(公告)号：US07538109B2
公开(公告)日：2009-05-26
申请号：US10555061
申请日：2004-04-26
IPC分类号： A01N43/58 , A61K31/50 , A01N43/60 , A61K31/495 , C07D241/36
CPC分类号： C07D401/12 , C07D241/44
摘要： The invention relates to quinoxalinone derivatives of general Formula (I) and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists. General Formula (I) wherein X and R1-R9 are as defined in the description
摘要翻译： 本发明涉及通式（I）的喹喔啉酮衍生物及其在制备药物组合物中作为活性成分的用途。 本发明还涉及包括制备化合物的方法，含有一种或多种这些化合物的药物组合物，特别是其作为食欲素受体拮抗剂的用途的相关方面。 通式（I）其中X和R 1 -R 9如说明书中所定义
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