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    METHODS AND SYSTEMS FOR POLYMER PRECIPITATION AND GENERATION OF PARTICLES
    1.
    发明申请
    METHODS AND SYSTEMS FOR POLYMER PRECIPITATION AND GENERATION OF PARTICLES 有权
    聚合物降解和生成颗粒的方法和系统

    公开(公告)号：US20130317208A1

    公开(公告)日：2013-11-28

    申请号：US13864429

    申请日：2013-04-17

    Applicant: J. Michael Ramstack ,  Thomas C. Crawford

    Inventor： J. Michael Ramstack ,  Thomas C. Crawford

    IPC: C08B37/16

    CPC classification number: C08B37/0012

    Abstract: Processes for precipitating a polymer from a polymer-containing fluid are disclosed, which include providing a vessel housing a medium that provides one or more precipitation surfaces. A polymer-containing fluid, e.g., a polymer solution, dispersion or mixed solution/dispersion, and an anti-solvent can be introduced into the vessel so as to cause precipitation of at least a portion of the polymer on at least one of the precipitation surfaces. In some embodiments, the polymer contains one or more cyclic oligosaccharide moieties, such as one or more cyclodextrin moieties (e.g., α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin). The polymer can be any of a linear or branched polymer. The polymer can be any of polycation, a polyanion, or a non-ionic polymer. Also disclosed herein are precipitation surfaces with polymer precipitated thereon.

    Abstract translation: 公开了从含聚合物的流体中沉淀聚合物的方法，其包括提供容纳提供一个或多个沉淀表面的介质的容器。 可以将含聚合物的流体，例如聚合物溶液，分散体或混合溶液/分散体和反溶剂引入容器中，以使至少一部分聚合物沉淀在至少一个沉淀 表面。 在一些实施方案中，聚合物含有一个或多个环状寡糖部分，例如一个或多个环糊精部分（例如α-环糊精，β-环糊精和γ-环糊精）。 聚合物可以是直链或支链聚合物中的任何一种。 聚合物可以是聚阳离子，聚阴离子或非离子聚合物中的任何一种。 本文还公开了其上沉淀有聚合物的沉淀表面。

    Methods and systems for polymer precipitation and generation of particles
    2.
    发明授权
    Methods and systems for polymer precipitation and generation of particles 有权

    公开(公告)号：US09598503B2

    公开(公告)日：2017-03-21

    申请号：US13864429

    申请日：2013-04-17

    Applicant: J. Michael Ramstack ,  Thomas C. Crawford

    Inventor： J. Michael Ramstack ,  Thomas C. Crawford

    IPC: C08B37/16

    CPC classification number: C08B37/0012

    Abstract: Processes for precipitating a polymer from a polymer-containing fluid are disclosed, which include providing a vessel housing a medium that provides one or more precipitation surfaces. A polymer-containing fluid, e.g., a polymer solution, dispersion or mixed solution/dispersion, and an anti-solvent can be introduced into the vessel so as to cause precipitation of at least a portion of the polymer on at least one of the precipitation surfaces. In some embodiments, the polymer contains one or more cyclic oligosaccharide moieties, such as one or more cyclodextrin moieties (e.g., α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin). The polymer can be any of a linear or branched polymer. The polymer can be any of polycation, a polyanion, or a non-ionic polymer. Also disclosed herein are precipitation surfaces with polymer precipitated thereon.

    Preparation of microparticles having improved flow ability
    4.
    发明申请
    Preparation of microparticles having improved flow ability 审中-公开
    具有改善的流动能力的微粒的制备

    公开(公告)号：US20070260038A1

    公开(公告)日：2007-11-08

    申请号：US11812697

    申请日：2007-06-21

    Applicant: J. Michael Ramstack ,  Steven Wright ,  David Dickason

    Inventor： J. Michael Ramstack ,  Steven Wright ,  David Dickason

    IPC: C08F6/00

    CPC classification number: C08F6/005 ,  B01F17/0028 ,  B01J13/12

    Abstract: Methods for preparing microparticles having improved flowability to facilitate processing in automated equipment. Microparticles are conditioned so that a flowability index of the microparticles is greater than about 60. The conditioning preferably includes maintaining the microparticles at a conditioning temperature for a period of time. The conditioning can be used with microparticles containing an active agent, and with placebo microparticles, and it is reversible.

    Abstract translation: 制备具有改善的流动性以促进自动化设备中的加工的微粒的方法。 对微粒进行调节，使得微粒的流动指数大于约60.调理优选包括将微粒保持在调理温度一段时间。 调理剂可以与含有活性剂的微粒和安慰剂微粒一起使用，并且是可逆的。

    Preparation of microparticles having improved flowability
    5.
    发明授权
    Preparation of microparticles having improved flowability 有权
    具有改善的流动性的微粒的制备

    公开(公告)号：US07247319B2

    公开(公告)日：2007-07-24

    申请号：US10022859

    申请日：2001-12-20

    Applicant: J. Michael Ramstack ,  Steven G. Wright ,  David A. Dickason

    Inventor： J. Michael Ramstack ,  Steven G. Wright ,  David A. Dickason

    IPC: A61K9/50

    CPC classification number: C08F6/005 ,  B01F17/0028 ,  B01J13/12

    Abstract: Methods for preparing microparticles having improved flowability to facilitate processing in automated equipment. Microparticles are conditioned so that a flowability index of the microparticles is greater than about 60. The conditioning preferably includes maintaining the microparticles at a conditioning temperature for a period of time. The conditioning can be used with microparticles containing an active agent, and with placebo microparticles, and it is reversible.

    Abstract translation: 制备具有改善的流动性以促进自动化设备中的加工的微粒的方法。 对微粒进行调节，使得微粒的流动指数大于约60.调理优选包括将微粒保持在调理温度一段时间。 调理剂可以与含有活性剂的微粒和安慰剂微粒一起使用，并且是可逆的。

    Method for fabricating nanoparticles
    7.
    发明授权
    Method for fabricating nanoparticles 有权
    制造纳米粒子的方法

    公开(公告)号：US08546521B2

    公开(公告)日：2013-10-01

    申请号：US13357977

    申请日：2012-01-25

    Applicant: J. Michael Ramstack ,  John Podobinski

    Inventor： J. Michael Ramstack ,  John Podobinski

    IPC: C08G63/02 ,  C08G634/00

    CPC classification number: B01D35/30 ,  B01D61/027 ,  B01D2239/0258 ,  B01D2315/10 ,  B01D2315/16 ,  B01J14/00 ,  B01J19/00 ,  B01J2219/00006 ,  B82Y5/00 ,  B82Y40/00 ,  C08J3/14 ,  C08J2367/04

    Abstract: Systems and methods are provided for filtering a fluid containing nanoparticles. The systems and methods generally include introducing a stream of the nanoparticle-containing fluid into a holding vessel, and extracting at least a part of a nanoparticle-containing fluid accumulated in the holding vessel. The extracted nanoparticle-containing fluid is passed through a filtration module to separate a nanoparticle-containing retentate from a permeate, and the retentate is returned to the vessel. The filtration cycle can be repeated until a desired concentration of the nanoparticles is achieved in the holding vessel. In many embodiments, the generation of the nanoparticle-containing fluid and its filtration are performed concurrently.

    Abstract translation: 提供了用于过滤含有纳米颗粒的流体的系统和方法。 系统和方法通常包括将含纳米颗粒的流体流引入保持容器中，以及提取在储存容器中积聚的含纳米颗粒的流体的至少一部分。 将提取的含纳米颗粒的流体通过过滤模块以从渗透物中分离含纳米颗粒的渗余物，并将滞留物返回到容器中。 可以重复该过滤循环，直到在保持容器中达到所需的纳米颗粒浓度。 在许多实施方案中，同时进行含纳米颗粒的流体的产生及其过滤。

    Preparation of microparticles having a selected release profile
    10.
    发明授权
    Preparation of microparticles having a selected release profile 有权
    具有选择的释放曲线的微粒的制备

    公开(公告)号：US06194006B1

    公开(公告)日：2001-02-27

    申请号：US09223276

    申请日：1998-12-30

    Applicant: Shawn L. Lyons ,  J. Michael Ramstack ,  Steven G. Wright

    Inventor： Shawn L. Lyons ,  J. Michael Ramstack ,  Steven G. Wright

    IPC: A61K914

    CPC classification number: A61K9/1647 ,  A61K9/1694 ,  B01J13/02 ,  Y10T428/2982

    Abstract: An improved method for preparing microparticles that exhibit controlled release of an effective amount of an active agent over an extended period of time. More particularly, a method is provided for preparing microparticles having a selected release profile for release of active agent contained in the microparticles. By adjusting the degree of drying that is performed during the preparation of the microparticles, the release profile can be controlled. By performing no intermediate drying, an initial burst and a substantially linear release profile is achieved. By performing substantially complete intermediate drying, an initial lag phase and a substantially sigmoidal release profile is achieved.

    Abstract translation: 一种用于制备在长时间内显示有效量的活性剂的受控释放的微粒的改进方法。 更具体地，提供了一种制备具有选择的释放曲线的微粒以释放微粒中所含的活性剂的方法。 通过调节在制备微粒期间进行的干燥程度，可以控制剥离曲线。 通过不进行中间干燥，实现初始脉冲串和基本上线性的释放曲线。 通过进行基本上完全的中间干燥，实现了初始滞后期和基本上S形释放曲线。

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