公开(公告)号：US20240132835A1

公开(公告)日：2024-04-25

申请号：US17769373

申请日：2020-10-15

Applicant: JANSSEN BIOTECH, INC.

Inventor： James Vincent PRICE ,  Stefanie BERGES-VORSANGER ,  Amalie LEVY ,  Steven SAVAGE ,  Abbey WEITH

IPC: C12N5/00 ,  C12M1/00 ,  C12M1/06 ,  C12M1/34 ,  C12M1/36

CPC classification number: C12N5/00 ,  C12M27/06 ,  C12M29/06 ,  C12M41/32 ,  C12M41/36 ,  C12M41/48

Abstract: Materials and methods to control a nutrient feed in a cell culture process is provided. A sample is received from a bioreactor comprising a cell culture. A viable cell density and a residual nutrient measurement are determined from the received sample. A daily nutrient feeding target is calculated based on the viable cell density and the residual nutrient measurement. The nutrient is fed to the bioreactor according to the calculated daily nutrient feeding target.

公开(公告)号：US20240228948A9

公开(公告)日：2024-07-11

申请号：US17769373

申请日：2020-10-16

Applicant: JANSSEN BIOTECH, INC.

Inventor： James Vincent PRICE ,  Stefanie BERGES-VORSANGER ,  Amalie LEVY ,  Steven SAVAGE ,  Abbey WEITH

IPC: C12N5/00 ,  C12M1/00 ,  C12M1/06 ,  C12M1/34 ,  C12M1/36

CPC classification number: C12N5/00 ,  C12M27/06 ,  C12M29/06 ,  C12M41/32 ,  C12M41/36 ,  C12M41/48

Abstract: Materials and methods to control a nutrient feed in a cell culture process is provided. A sample is received from a bioreactor comprising a cell culture. A viable cell density and a residual nutrient measurement are determined from the received sample. A daily nutrient feeding target is calculated based on the viable cell density and the residual nutrient measurement. The nutrient is fed to the bioreactor according to the calculated daily nutrient feeding target.