公开(公告)号：US20240067754A1

公开(公告)日：2024-02-29

申请号：US18461191

申请日：2023-09-05

Applicant: Janssen Biotech, Inc.

Inventor： Jinquan LUO ,  Lauren BOUCHER ,  Michael FELDKAMP ,  Michael DIEM ,  Anthony A. ARMSTRONG ,  Alexey TEPLYAKOV ,  Chichi HUANG

IPC: C07K16/42 ,  C07K14/705 ,  C07K16/00

CPC classification number: C07K16/4283 ,  C07K14/705 ,  C07K16/00 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/94

Abstract: Disclosed are materials and methods for improved single chain variable fragments.

公开(公告)号：US20220356266A1

公开(公告)日：2022-11-10

申请号：US17233021

申请日：2021-04-16

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar GANESAN ,  Adam ZWOLAK ,  Jason HO ,  Natasa OBERMAJER ,  Michael DIEM ,  Sanjaya SINGH ,  Sathyadevi VENKATARAMANI ,  Theresa MCDEVITT ,  Fei SHEN

IPC: C07K16/30 ,  C07K16/28

Abstract: A population of antibodies, wherein less than 80% of the oligosaccharides covalently attached to the population of the antibodies via N297 residues thereof comprise a core fucose residue; and wherein the population of the antibodies comprises an antibody which Fc region comprises K338A and T437R mutations, or K248E and T437R mutations.