公开(公告)号：US20200291121A1

公开(公告)日：2020-09-17

申请号：US16753488

申请日：2018-10-02

Applicant: JOINT STOCK COMPANY "BIOCAD"

Inventor： Ekaterina Vladimirovna SOFRONOVA ,  Aleksei Konstantinovich MISORIN ,  Aleksandr Nikolaevich DORONIN ,  Timofey Aleksandrovich NEMANKIN ,  Aleksandra Aleksandrovna SOZONOVA ,  Galina Stepanovna ZHIRIVSKAIA ,  Sergey Aleksandrovich LEGOTSKY ,  Anna Konstantinovna VLADIMIROVA ,  Alina Valerevna BELIASNIKOVA ,  Mariia Aleksandrovna SHCHEMELEVA ,  Pavel Andreevich IAKOVLEV ,  Valery Vladimirovich SOLOVYEV ,  Elena Andreevna KRENDELEVA ,  Natalia Evgenevna PESTOVA ,  Dmitry Valentinovich MOROZOV

IPC: C07K16/28 ,  C12N15/64

Abstract: The present invention relates to biotechnology and provides antibodies that specifically bind to IL-5Rα. The invention also relates to DNA encoding said antibodies, the corresponding expression vectors and methods of production thereof, as well as methods of treatment using said antibodies.

公开(公告)号：US20200031952A1

公开(公告)日：2020-01-30

申请号：US16564148

申请日：2019-09-09

Applicant: CLOSED JOINT STOCK COMPANY "BIOCAD"

Inventor： Andrey Borisovich ULITIN ,  Stanislav Rudolfovich EVDOKIMOV ,  Valeriy Vladimirovich SOLOVIEV ,  Yulia Sergeevna CHERNYKH ,  Olga Vladimirovna GONCHAROVA ,  Dmitriy Valerievich KORZHAVIN ,  Tatyana Veniaminovna CHERNOVSKAYA ,  Timofey Aleksandrovich NEMANKIN ,  Roman Alexeevich IVANOV ,  Dmitriy Valentinovich MOROZOV ,  Victoria Mikhailovna EKIMOVA ,  Ekaterina Vladimirovna SOFRONOVA ,  Yakov Yurevich USTYUGOV

IPC: C07K16/46 ,  A61K39/395 ,  A61K45/06 ,  C07K16/24

Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.

公开(公告)号：US20170066843A1

公开(公告)日：2017-03-09

申请号：US15254225

申请日：2016-09-01

Applicant: CLOSED JOINT STOCK COMPANY "BIOCAD"

Inventor： Andrey Borisovich ULITIN ,  Stanislav Rudolfovich EVDOKIMOV ,  Valeriy Vladimirovich SOLOVIEV ,  Yulia Sergeevna CHERNYH ,  Olga Vladimirovna GONCHAROVA ,  Dmitriy Valerievich KORZHAVIN ,  Tatyana Veniaminovna CHERNOVSKAYA ,  Timofey Aleksandrovich NEMANKIN ,  Roman Alexeevich IVANOV ,  Dmitriy Valentinovich MOROZOV ,  Victoria Mikhailovna EKIMOVA ,  Ekaterina Vladimirovna SOFRONOVA ,  Yakov Yurevich USTYUGOV

IPC: C07K16/46 ,  A61K45/06 ,  C07K16/24 ,  A61K39/395

Abstract: The monoclonal IgG-type antibodies were suggested comprising variable domains represented by a combination of VHH-derivative with a variable domain of the light chain VL. Said antibodies can comprise amino acid substitutions at positions 44 and 45 (Kabat numbering) or combinations thereof. Antibodies of the invention possess increased affinity and improved aggregation stability.

Abstract translation: 提出了单克隆IgG型抗体，其包含由VHH衍生物与轻链VL的可变结构域组合表示的可变结构域。 所述抗体可以包含位置44和45（Kabat编号）或其组合的氨基酸取代。 本发明的抗体具有增加的亲和力和改进的聚集稳定性。