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公开(公告)号:US08691953B2
公开(公告)日:2014-04-08
申请号:US13330902
申请日:2011-12-20
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C07K16/00
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US20120115164A1
公开(公告)日:2012-05-10
申请号:US13330902
申请日:2011-12-20
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US08080392B2
公开(公告)日:2011-12-20
申请号:US13025002
申请日:2011-02-10
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C12N15/09
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US07906622B2
公开(公告)日:2011-03-15
申请号:US12414267
申请日:2009-03-30
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C07K14/52
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US07579440B2
公开(公告)日:2009-08-25
申请号:US10777790
申请日:2004-02-11
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C07K14/00
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
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公开(公告)号:US07148330B2
公开(公告)日:2006-12-12
申请号:US10000776
申请日:2001-11-30
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C07K16/24
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US20090191569A1
公开(公告)日:2009-07-30
申请号:US12414267
申请日:2009-03-30
申请人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
发明人: Jacqueline C. Timans , Stefan Karl-Heinz Pflanz , Robert A. Kastelein , J. Fernando Bazan , Donna Rennick , Rene de Waal Malefyt , Jeanne Cheung
IPC分类号: C12Q1/68 , G01N33/53 , C12P21/06 , C12N5/00 , C12N5/02 , C12N15/63 , C07K7/08 , C07K16/00 , C07H21/02
CPC分类号: C07K14/54 , C07K14/5434 , C07K16/244 , C12Q1/6881 , Y10S436/808
摘要: Purified genes encoding a cytokine or composite cytokine from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding these molecules are provided. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译: 提供了编码来自哺乳动物的细胞因子或复合细胞因子的纯化基因,与其相关的试剂,包括纯化蛋白质,特异性抗体和编码这些分子的核酸。 还提供了使用所述试剂和诊断试剂盒的方法。
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公开(公告)号:US07071308B2
公开(公告)日:2006-07-04
申请号:US10927228
申请日:2004-08-25
申请人: Pedro A. Reche-Gallardo , Vassilli Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Fernando Bazan , Robert A. Kastelein
发明人: Pedro A. Reche-Gallardo , Vassilli Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Fernando Bazan , Robert A. Kastelein
IPC分类号: C07K14/715 , C12N15/12
CPC分类号: C07K16/244 , C07K14/54 , C07K14/7155 , G01N33/6863 , G01N33/6869 , G01N2333/54 , G01N2500/02
摘要: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
摘要翻译: 编码哺乳动物细胞因子受体的核酸,例如细胞因子IL-B50,纯化的蛋白质及其片段。 还提供了抗体,包括多克隆和单克隆抗体。 描述了用于诊断和治疗用途的组合物的方法。
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公开(公告)号:US07569224B2
公开(公告)日:2009-08-04
申请号:US11297957
申请日:2005-12-09
申请人: Pedro A. Reche-Gallardo , Vassili Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Fernando Bazan , Robert A. Kastelein
发明人: Pedro A. Reche-Gallardo , Vassili Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Fernando Bazan , Robert A. Kastelein
IPC分类号: C07K16/28 , A61K39/395
CPC分类号: C07K16/244 , C07K14/54 , C07K14/7155 , G01N33/6863 , G01N33/6869 , G01N2333/54 , G01N2500/02
摘要: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
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公开(公告)号:US20120177658A1
公开(公告)日:2012-07-12
申请号:US13287456
申请日:2011-11-02
申请人: Pedro A. Reche-Gallardo , Vassilli Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Fernando Bazan , Robert A. Kastelein
发明人: Pedro A. Reche-Gallardo , Vassilli Soumelis , Yong-Jun Liu , Rene de Waal Malefyt , J. Fernando Bazan , Robert A. Kastelein
IPC分类号: A61K39/395 , C12N5/02 , A61P35/00
CPC分类号: C07K16/244 , C07K14/54 , C07K14/7155 , G01N33/6863 , G01N33/6869 , G01N2333/54 , G01N2500/02
摘要: Nucleic acids encoding mammalian cytokine receptor, e.g., for cytokine IL-B50, purified proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are described.
摘要翻译: 编码哺乳动物细胞因子受体的核酸,例如细胞因子IL-B50,纯化的蛋白质及其片段。 还提供了抗体,包括多克隆和单克隆抗体。 描述了用于诊断和治疗用途的组合物的方法。
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