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公开(公告)号：US07928373B2
公开(公告)日：2011-04-19
申请号：US11713210
申请日：2007-03-02
IPC分类号： H01J48/42
CPC分类号： H01J49/427
摘要： Ions in a predefined narrow mass to charge ratio range are isolated in an ion trap by adjusting the field and using ejection frequency waveform(s). The ejection waveforms have frequency components in a first and a second dimension, and, are applied across electrodes aligned along a first and a second dimension. Thus the mass-to-charge ratio isolation window is controlled and has an improved resolution without increasing the number of frequency components.
摘要翻译： 通过调整场和使用喷射频率波形，在离子阱中隔离预定义的窄质量与电荷比范围内的离子。 喷射波形具有第一和第二维度的频率分量，并且沿着沿第一和第二维度排列的电极施加。 因此，质量 - 电荷比隔离窗口被控制并且具有改进的分辨率而不增加频率分量的数量。
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公开(公告)号：US07456396B2
公开(公告)日：2008-11-25
申请号：US10922809
申请日：2004-08-19
IPC分类号： H01J49/42
CPC分类号： H01J49/427
摘要： Ions in a predefined narrow mass to charge ratio range are isolated in an ion trap by adjusting the field and using ejection frequency waveform(s). Thus the mass-to-charge ratio isolation window is controlled and has an improved resolution without increasing the number of frequency components.
摘要翻译： 通过调整场和使用喷射频率波形，在离子阱中隔离预定义的窄质量与电荷比范围内的离子。 因此，质量 - 电荷比隔离窗口被控制并且具有改进的分辨率而不增加频率分量的数量。
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3.发明授权公开(公告)号：US08198580B2
公开(公告)日：2012-06-12
申请号：US12710245
申请日：2010-02-22
CPC分类号： H01J49/0418 , H01J49/0045 , H01J49/0404 , H01J49/4225
摘要： A dual ion trap mass analyzer includes adjacently positioned first and second two-dimensional ion traps respectively maintained at relatively high and low pressures. Functions favoring high pressure (cooling and fragmentation) may be performed in the first trap, and functions favoring low pressure (isolation and analytical scanning) may be performed in the second trap. Ions may be transferred between the first and second trap through a plate lens having a small aperture that presents a pumping restriction and allows different pressures to be maintained in the two traps. The differential-pressure environment of the dual ion trap mass analyzer facilitates the use of high-resolution analytical scan modes without sacrificing ion capture and fragmentation efficiencies.
摘要翻译： 双离子阱质量分析仪包括分别保持在相对高和低压力下的相邻定位的第一和第二二维离子阱。 可以在第一捕集器中执行有利于高压（冷却和碎裂）的功能，并且可以在第二捕集器中执行有利于低压（隔离和分析扫描）的功能。 离子可以通过具有小孔径的平板透镜在第一和第二捕集器之间转移，该透镜具有泵送限制并且允许在两个捕集器中保持不同的压力。 双离子阱质量分析仪的差压环境有助于使用高分辨率分析扫描模式，而不会牺牲离子捕获和碎裂效率。
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4.发明授权公开(公告)号：US07692142B2
公开(公告)日：2010-04-06
申请号：US11639273
申请日：2006-12-13
CPC分类号： H01J49/0418 , H01J49/0045 , H01J49/0404 , H01J49/4225
摘要： A dual ion trap mass analyzer includes adjacently positioned first and second two-dimensional ion traps respectively maintained at relatively high and low pressures. Functions favoring high pressure (cooling and fragmentation) may be performed in the first trap, and functions favoring low pressure (isolation and analytical scanning) may be performed in the second trap. Ions may be transferred between the first and second trap through a plate lens having a small aperture that presents a pumping restriction and allows different pressures to be maintained in the two traps. The differential-pressure environment of the dual ion trap mass analyzer facilitates the use of high-resolution analytical scan modes without sacrificing ion capture and fragmentation efficiencies.
摘要翻译： 双离子阱质量分析仪包括分别保持在相对高和低压力下的相邻定位的第一和第二二维离子阱。 可以在第一捕集器中执行有利于高压（冷却和碎裂）的功能，并且可以在第二捕集器中执行有利于低压（隔离和分析扫描）的功能。 离子可以通过具有小孔径的平板透镜在第一和第二捕集器之间转移，该透镜具有泵送限制并且允许在两个捕集器中保持不同的压力。 双离子阱质量分析仪的差压环境有助于使用高分辨率分析扫描模式，而不会牺牲离子捕获和碎裂效率。
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公开(公告)号：US08168943B2
公开(公告)日：2012-05-01
申请号：US11845723
申请日：2007-08-27
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , H01J49/0045
摘要： Methods and apparatus for data-dependent mass spectrometric MS/MS or MSn analysis are disclosed. The methods may include determination of the charge state of an ion species of interest, followed by automated selection of a dissociation type (e.g., CAD, ETD, or ETD followed by a non-dissociative charge reduction or collisional activation) based at least partially on the determined charge state. The ion species of interest is then dissociated in accordance with the selected dissociation type, and an MS/MS or MSn spectrum of the resultant product ions may be acquired.
摘要翻译： 公开了数据依赖质谱MS / MS或MSn分析的方法和装置。 所述方法可以包括确定感兴趣的离子物质的电荷状态，然后至少部分地基于自由选择解离型（例如，CAD，ETD或ETD，随后是非解离电荷减少或碰撞激活） 确定的充电状态。 然后根据选择的解离型解离感兴趣的离子种类，并且可以获得所得产物离子的MS / MS或MSn光谱。
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6.发明授权
公开(公告)号：US5182451A
公开(公告)日：1993-01-26
申请号：US849970
申请日：1992-03-12
申请人： Jae C. Schwartz , John E. P. Syka , John N. Louris
发明人： Jae C. Schwartz , John E. P. Syka , John N. Louris
CPC分类号： H01J49/424 , H01J49/429
摘要： A method of mass analyzing a sample including the steps of defining a trap volume with a three-dimensional quadrupole field for trapping ions within a predetermined range of mass-to-charge ratio, forming or injecting ions within the trap volume such that those within the predetermined mass-to-charge ratio range are trapped within the trap volume, applying a supplementary AC field superimposed on the three-dimensional quadrupole field to form combined fields, scanning the combined fields to eject ions of consecutive mass-to-charge ratio from the trap volume for detection characterized in that the supplementary field has an amplitude just sufficient to eject the ions and that the supplementary field has a beta value below 0.891 and that the combined fields are scanned at a rate so that a length of time corresponding to 200 cycles or more of the supplementary AC field passes per consecutive thomson.
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7.发明申请公开(公告)号：US20080142705A1
公开(公告)日：2008-06-19
申请号：US11639273
申请日：2006-12-13
IPC分类号： H01J49/26
CPC分类号： H01J49/0418 , H01J49/0045 , H01J49/0404 , H01J49/4225
摘要： A dual ion trap mass analyzer includes adjacently positioned first and second two-dimensional ion traps respectively maintained at relatively high and low pressures. Functions favoring high pressure (cooling and fragmentation) may be performed in the first trap, and functions favoring low pressure (isolation and analytical scanning) may be performed in the second trap. Ions may be transferred between the first and second trap through a plate lens having a small aperture that presents a pumping restriction and allows different pressures to be maintained in the two traps. The differential-pressure environment of the dual ion trap mass analyzer facilitates the use of high-resolution analytical scan modes without sacrificing ion capture and fragmentation efficiencies.
摘要翻译： 双离子阱质量分析仪包括分别保持在相对高和低压力下的相邻定位的第一和第二二维离子阱。 可以在第一捕集器中执行有利于高压（冷却和碎裂）的功能，并且可以在第二捕集器中执行有利于低压（隔离和分析扫描）的功能。 离子可以通过具有小孔径的平板透镜在第一和第二捕集器之间转移，该透镜具有泵送限制并且允许在两个捕集器中保持不同的压力。 双离子阱质量分析仪的差压环境有助于使用高分辨率分析扫描模式，而不会牺牲离子捕获和碎裂效率。
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公开(公告)号：US07238936B2
公开(公告)日：2007-07-03
申请号：US11020744
申请日：2004-12-23
IPC分类号： H01J49/40
CPC分类号： H01J49/025
摘要： A detector assembly has a current measuring device with a saturation threshold level, and a gain variation means. A signal is generated in response to the particles detected, a first data point corresponding to a peak of interest is acquired from the signal. If the first data point is near, at or above the saturation threshold level of the current measuring device, the gain of the gain variation means is adjusted such that the peak of interest in the signal is reduced in intensity.
摘要翻译： 检测器组件具有饱和阈值电平的电流测量装置和增益变化装置。 响应于检测到的粒子产生信号，从信号中获取与感兴趣的峰值对应的第一数据点。 如果第一数据点接近，等于或高于当前测量装置的饱和阈值电平，则调整增益变化装置的增益，使得信号中的感兴趣的峰值强度降低。
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公开(公告)号：US20080067360A1
公开(公告)日：2008-03-20
申请号：US11804619
申请日：2007-05-18
申请人： Michael W. Senko , Jae C. Schwartz
发明人： Michael W. Senko , Jae C. Schwartz
IPC分类号： B01D59/44
CPC分类号： H01J49/423
摘要： The invention provides a two-dimensional ion trap, comprising a plurality of elongate electrodes positioned between first and second end electrodes, the plurality of electrodes and first and second end electrodes defining a trapping volume. A controller in electrical communication with the plurality of elongate electrodes and the first and second end electrodes is configured to progressively vary a periodic voltage applied to at least one of the plurality of elongate electrodes to cause ions to be radially ejected from the ion trap in order of their mass to charge ratios. Concurrently, the controller is configured to progressively vary a DC offset of least one of the first and second end electrodes with respect to the plurality of elongate electrodes.
摘要翻译： 本发明提供一种二维离子阱，其包括位于第一和第二端电极之间的多个细长电极，多个电极和第一和第二端电极限定捕获体积。 与多个细长电极和第一和第二端电极电连通的控制器被配置为逐渐改变施加到多个细长电极中的至少一个细长电极的周期性电压，以使离子按顺序从离子阱径向喷射 的质量比。 同时，控制器被配置为逐渐改变第一和第二端电极中的至少一个相对于多个细长电极的DC偏移。
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公开(公告)号：US07180057B1
公开(公告)日：2007-02-20
申请号：US11197083
申请日：2005-08-04
申请人： Michael W. Senko , Jae C. Schwartz
发明人： Michael W. Senko , Jae C. Schwartz
IPC分类号： H01J49/42
CPC分类号： H01J49/4225 , H01J49/423
摘要： An aperture design for a linear ion trap is provided in which the aperture is optimized to minimize possible axial field inhomogeneities whilst preserving the structural integrity of the quadrupole rods. In general, the invention provides a linear ion trap for trapping and subsequently ejecting ions. The linear ion trap comprises a plurality of rods which define an interior trapping volume which has an axis extending longitudinally. One or more of the rods includes an aperture which extends both radially through the rod and longitudinally along the rod. The aperture being configured such that the ions can pass from the interior trapping volume through the aperture to a region outside the interior trapping volume. At least one recess is disposed adjacent the aperture, extending longitudinally along the rod and facing the interior trapping volume, the recess not extending radially through the rod.
摘要翻译： 提供了一种用于线性离子阱的孔径设计，其中孔径被优化以最小化可能的轴向场不均匀性，同时保持四极杆的结构完整性。 通常，本发明提供了用于捕获和随后喷射离子的线性离子阱。 线性离子阱包括多个限定内部捕获体积的杆，其具有纵向延伸的轴线。 杆中的一个或多个包括孔径，其径向延伸穿过杆并沿着杆纵向延伸。 孔被构造成使得离子可以从内部捕获体积通过孔传播到内部捕获体积外部的区域。 至少一个凹部邻近孔设置，沿着杆纵向延伸并且面向内部捕获体积，凹部不径向延伸穿过杆。
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