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1.发明授权
公开(公告)号：US5182451A
公开(公告)日：1993-01-26
申请号：US849970
申请日：1992-03-12
申请人： Jae C. Schwartz , John E. P. Syka , John N. Louris
发明人： Jae C. Schwartz , John E. P. Syka , John N. Louris
CPC分类号： H01J49/424 , H01J49/429
摘要： A method of mass analyzing a sample including the steps of defining a trap volume with a three-dimensional quadrupole field for trapping ions within a predetermined range of mass-to-charge ratio, forming or injecting ions within the trap volume such that those within the predetermined mass-to-charge ratio range are trapped within the trap volume, applying a supplementary AC field superimposed on the three-dimensional quadrupole field to form combined fields, scanning the combined fields to eject ions of consecutive mass-to-charge ratio from the trap volume for detection characterized in that the supplementary field has an amplitude just sufficient to eject the ions and that the supplementary field has a beta value below 0.891 and that the combined fields are scanned at a rate so that a length of time corresponding to 200 cycles or more of the supplementary AC field passes per consecutive thomson.
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2.发明授权
公开(公告)号：US4686367A
公开(公告)日：1987-08-11
申请号：US773339
申请日：1985-09-06
申请人： John N. Louris , John E. P. Syka , Paul E. Kelley
发明人： John N. Louris , John E. P. Syka , Paul E. Kelley
CPC分类号： H01J49/424 , H01J49/0081 , H01J49/145 , H01J49/429
摘要： The method of performing chemical ionization and mass analysis with a quadrupole ion trap.
摘要翻译： 用四极离子阱进行化学电离和质量分析的方法。
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公开(公告)号：USRE34000E
公开(公告)日：1992-07-21
申请号：US499947
申请日：1990-03-27
CPC分类号： H01J49/424 , H01J49/0063 , H01J49/0081 , H01J49/429
摘要： A simple and economical method of mass analyzing a sample by means of a quadrupole ion trap mass spectrometer in an MS/MS mode comprises the steps of forming ions within a trap structure, changing the RF and DC voltages in such a way that the ions with mass-to-charge ratios within a desired range will be and remain trapped within the trap structure, dissociating such ions into fragments by collisions and increasing the field intensity again so that the generated fragments will become unstable and exit the trap volume sequentially to be detected. A supplementary AC field may be applied additionally to provide various scan modes as well as dissociate the ions.
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公开(公告)号：US4736101A
公开(公告)日：1988-04-05
申请号：US84518
申请日：1987-08-11
CPC分类号： H01J49/424 , H01J49/0063 , H01J49/0081 , H01J49/429
摘要： A simple and economical method of mass analyzing a sample by means of a quadrupole ion trap mass spectrometer in an MS/MS mode comprises the steps of forming ions within a trap structure, changing the RF and DC voltages in such a way that the ions with mass-to-charge ratios within a desired range will be and remain trapped within the trap structure, dissociating such ions into fragments by collisions and increasing the field intensity again so that the generated fragments will become unstable and exit the trap volume sequentially to be detected. A supplementary AC field may be applied additionally to provide various scan modes as well as dissociate the ions.
摘要翻译： 以MS / MS模式通过四极离子阱质谱仪对样品进行质量分析的简单而经济的方法包括以下步骤：在捕获结构内形成离子，改变RF和DC电压，使得离子与 在所需范围内的质荷比将被捕获在陷阱结构内，并且通过碰撞将这些离子解离成碎片，并再次增加场强，使得所产生的片段将变得不稳定并顺序地离开陷阱体积以被检测 。 附加的AC场可以另外施加以提供各种扫描模式以及离子离解。
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5.发明授权公开(公告)号：US08198580B2
公开(公告)日：2012-06-12
申请号：US12710245
申请日：2010-02-22
CPC分类号： H01J49/0418 , H01J49/0045 , H01J49/0404 , H01J49/4225
摘要： A dual ion trap mass analyzer includes adjacently positioned first and second two-dimensional ion traps respectively maintained at relatively high and low pressures. Functions favoring high pressure (cooling and fragmentation) may be performed in the first trap, and functions favoring low pressure (isolation and analytical scanning) may be performed in the second trap. Ions may be transferred between the first and second trap through a plate lens having a small aperture that presents a pumping restriction and allows different pressures to be maintained in the two traps. The differential-pressure environment of the dual ion trap mass analyzer facilitates the use of high-resolution analytical scan modes without sacrificing ion capture and fragmentation efficiencies.
摘要翻译： 双离子阱质量分析仪包括分别保持在相对高和低压力下的相邻定位的第一和第二二维离子阱。 可以在第一捕集器中执行有利于高压（冷却和碎裂）的功能，并且可以在第二捕集器中执行有利于低压（隔离和分析扫描）的功能。 离子可以通过具有小孔径的平板透镜在第一和第二捕集器之间转移，该透镜具有泵送限制并且允许在两个捕集器中保持不同的压力。 双离子阱质量分析仪的差压环境有助于使用高分辨率分析扫描模式，而不会牺牲离子捕获和碎裂效率。
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6.发明授权公开(公告)号：US07692142B2
公开(公告)日：2010-04-06
申请号：US11639273
申请日：2006-12-13
CPC分类号： H01J49/0418 , H01J49/0045 , H01J49/0404 , H01J49/4225
摘要： A dual ion trap mass analyzer includes adjacently positioned first and second two-dimensional ion traps respectively maintained at relatively high and low pressures. Functions favoring high pressure (cooling and fragmentation) may be performed in the first trap, and functions favoring low pressure (isolation and analytical scanning) may be performed in the second trap. Ions may be transferred between the first and second trap through a plate lens having a small aperture that presents a pumping restriction and allows different pressures to be maintained in the two traps. The differential-pressure environment of the dual ion trap mass analyzer facilitates the use of high-resolution analytical scan modes without sacrificing ion capture and fragmentation efficiencies.
摘要翻译： 双离子阱质量分析仪包括分别保持在相对高和低压力下的相邻定位的第一和第二二维离子阱。 可以在第一捕集器中执行有利于高压（冷却和碎裂）的功能，并且可以在第二捕集器中执行有利于低压（隔离和分析扫描）的功能。 离子可以通过具有小孔径的平板透镜在第一和第二捕集器之间转移，该透镜具有泵送限制并且允许在两个捕集器中保持不同的压力。 双离子阱质量分析仪的差压环境有助于使用高分辨率分析扫描模式，而不会牺牲离子捕获和碎裂效率。
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公开(公告)号：US08168943B2
公开(公告)日：2012-05-01
申请号：US11845723
申请日：2007-08-27
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , H01J49/0045
摘要： Methods and apparatus for data-dependent mass spectrometric MS/MS or MSn analysis are disclosed. The methods may include determination of the charge state of an ion species of interest, followed by automated selection of a dissociation type (e.g., CAD, ETD, or ETD followed by a non-dissociative charge reduction or collisional activation) based at least partially on the determined charge state. The ion species of interest is then dissociated in accordance with the selected dissociation type, and an MS/MS or MSn spectrum of the resultant product ions may be acquired.
摘要翻译： 公开了数据依赖质谱MS / MS或MSn分析的方法和装置。 所述方法可以包括确定感兴趣的离子物质的电荷状态，然后至少部分地基于自由选择解离型（例如，CAD，ETD或ETD，随后是非解离电荷减少或碰撞激活） 确定的充电状态。 然后根据选择的解离型解离感兴趣的离子种类，并且可以获得所得产物离子的MS / MS或MSn光谱。
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公开(公告)号：US07928373B2
公开(公告)日：2011-04-19
申请号：US11713210
申请日：2007-03-02
IPC分类号： H01J48/42
CPC分类号： H01J49/427
摘要： Ions in a predefined narrow mass to charge ratio range are isolated in an ion trap by adjusting the field and using ejection frequency waveform(s). The ejection waveforms have frequency components in a first and a second dimension, and, are applied across electrodes aligned along a first and a second dimension. Thus the mass-to-charge ratio isolation window is controlled and has an improved resolution without increasing the number of frequency components.
摘要翻译： 通过调整场和使用喷射频率波形，在离子阱中隔离预定义的窄质量与电荷比范围内的离子。 喷射波形具有第一和第二维度的频率分量，并且沿着沿第一和第二维度排列的电极施加。 因此，质量 - 电荷比隔离窗口被控制并且具有改进的分辨率而不增加频率分量的数量。
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公开(公告)号：US07456396B2
公开(公告)日：2008-11-25
申请号：US10922809
申请日：2004-08-19
IPC分类号： H01J49/42
CPC分类号： H01J49/427
摘要： Ions in a predefined narrow mass to charge ratio range are isolated in an ion trap by adjusting the field and using ejection frequency waveform(s). Thus the mass-to-charge ratio isolation window is controlled and has an improved resolution without increasing the number of frequency components.
摘要翻译： 通过调整场和使用喷射频率波形，在离子阱中隔离预定义的窄质量与电荷比范围内的离子。 因此，质量 - 电荷比隔离窗口被控制并且具有改进的分辨率而不增加频率分量的数量。
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10.发明授权Method of increasing the dynamic range and sensitivity of a quadrupole ion trap mass spectrometer operating in the chemical ionization mode 失效增加在化学电离模式下操作的四极离子阱质谱仪的动态范围和灵敏度的方法
公开(公告)号：US4771172A
公开(公告)日：1988-09-13
申请号：US53359
申请日：1987-05-22
CPC分类号： H01J49/145 , H01J49/424 , H01J49/4265
摘要： A method is disclosed for increasing the dynamic range and sensitivity of a quadrupole ion trap mass spectrometer operating in the chemical ionization mode. Prior to mass analysis, a prescan is performed with the ion trap and the ionization and reaction periods are adjusted to produce enough stored product or analyte ions to generate a good signal-to-noise ratio in the detection of trace amounts of analyte, yet not so many analyte ions that resolution in the mass spectrum is lost. A mass analysis scan is then performed with the ion trap using the ionization and reaction periods predetermined during the prescan.
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