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公开(公告)号：US20100144710A1
公开(公告)日：2010-06-10
申请号：US12530351
申请日：2008-02-28
申请人： Jalaj Arora , Methvin Isaac , Abdelmalik Slassi , Louise Edwards , Satheesh Nair , Fupeng Ma
发明人： Jalaj Arora , Methvin Isaac , Abdelmalik Slassi , Louise Edwards , Satheesh Nair , Fupeng Ma
IPC分类号： A61K31/496 , C07D401/04 , C07D403/04 , A61K31/551 , A61P25/18 , A61P25/00
CPC分类号： C07D213/61 , C07D213/84 , C07D213/85 , C07D241/24 , C07D295/192 , C07D401/12 , C07D405/12 , C07D417/12
摘要： Compounds of Formula I or pharmaceutically acceptable salts or solvates thereof, wherein A, B, D, Ar1, Ar2, R2, R3, R4, a, m and n are defined in the specification, methods for the use thereof, processes for making and pharmaceutical compositions containing the same.
摘要翻译： 式I化合物或其药学上可接受的盐或溶剂化物，其中A，B，D，Ar1，Ar2，R2，R3，R4，a，m和n在本说明书中定义，其使用方法，制备方法和 含有该组合物的药物组合物。
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2.发明授权Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 失效额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US07585881B2
公开(公告)日：2009-09-08
申请号：US11053752
申请日：2005-02-09
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tau Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tau Xin , Jalaj Arora
IPC分类号： A61K31/4439 , C07D401/14 , C07D413/04
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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3.发明申请ADDITIONAL HETEROPOLYCYCLIC COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS 审中-公开其他杂环化合物及其作为代谢谷氨酸受体拮抗剂的使用公开(公告)号：US20080045571A1
公开(公告)日：2008-02-21
申请号：US11840953
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4245 , A61P19/06 , A61P25/18 , A61P25/30 , A61P29/00 , A61P9/00 , C07D413/14 , C12N5/00 , C07D271/06 , A61P35/00 , A61P27/02 , A61P25/28 , A61P25/08 , A61P19/02 , A61K31/443
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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4.发明申请Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 审中-公开额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20070179188A1
公开(公告)日：2007-08-02
申请号：US10588702
申请日：2005-02-15
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald Mcleod , Alexander Minidis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4245 , C07D413/14 , C07D413/02
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula (I), to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式（I）化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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公开(公告)号：US20060122397A1
公开(公告)日：2006-06-08
申请号：US11274611
申请日：2005-11-14
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Donald McLeod , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Helena Gyback , Martin Johansson , Annika Kers , John Malmberg , Alexander Minidis , Karin Oscarsson , Mangus Waldman , Ulrika Yngve , Christoffer Osterwall
IPC分类号： A61K31/4439 , A61K31/4245 , C07D417/14 , C07D413/14 , C07D409/14
CPC分类号： C07D413/14 , C07D413/12 , C07D417/14
摘要： The present invention relates to new compounds of formula I, a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译： 本发明涉及新的式I化合物，其制备方法和其中制备的新中间体，含有所述化合物的药物制剂和所述化合物在治疗中的用途。
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公开(公告)号：US06380242B1
公开(公告)日：2002-04-30
申请号：US09469327
申请日：1999-12-22
申请人： Jalaj Arora , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Ashok Tehim , Tao Xin
发明人： Jalaj Arora , Louise Edwards , Methvin Isaac , Anne O'Brien , Abdelmalik Slassi , Ashok Tehim , Tao Xin
IPC分类号： A61K31382
CPC分类号： A61K31/415
摘要： The present invention is directed to compounds useful in the treatment of migraine which have the general formula (II).
摘要翻译： 本发明涉及可用于治疗具有通式（II）的偏头痛的化合物。
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7.发明申请公开(公告)号：US20060189661A1
公开(公告)日：2006-08-24
申请号：US11398556
申请日：2006-04-06
申请人： Bradford Wagenen , Thomas Stormann , Scott Moe , Susan Sheehan , Donald McLeod , Daryl Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
发明人： Bradford Wagenen , Thomas Stormann , Scott Moe , Susan Sheehan , Donald McLeod , Daryl Smith , Methvin Isaac , Abdelmalik Slassi , Ian Egle , Louise Edwards , Tomislav Stefanac , Tao Xin , Jalaj Arora , William Michne
IPC分类号： C07D413/04 , A61K31/4439
CPC分类号： C07D213/75 , C07D213/55 , C07D213/78 , C07D213/79 , C07D401/04 , C07D405/04 , C07D405/14 , C07D413/04 , C07D413/14
摘要： The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
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8.发明申请公开(公告)号：US20080015234A1
公开(公告)日：2008-01-17
申请号：US11840952
申请日：2007-08-18
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4439 , A61K31/4196 , A61K31/4245 , A61P19/06 , A61P25/18 , A61P25/30 , A61P29/00 , A61P9/00 , C07D413/14 , C12N5/00 , C07D271/06 , A61P35/00 , A61P27/02 , A61P25/28 , A61P25/08 , A61P19/02 , A61K31/443
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
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9.发明申请New compounds for the treatment of neurological, psychiatric or pain disorders 失效用于治疗神经，精神或疼痛疾病的新化合物公开(公告)号：US20070129408A1
公开(公告)日：2007-06-07
申请号：US11523717
申请日：2006-09-20
申请人： Alexander Minidis , David Wensbo , Methvin Isaac , Abdelmalik Slassi , Jalaj Arora , Tao Xin , Louise Edwards , Caroline Eriksson , Veronica Profir , Per-Olov Bergstrom
发明人： Alexander Minidis , David Wensbo , Methvin Isaac , Abdelmalik Slassi , Jalaj Arora , Tao Xin , Louise Edwards , Caroline Eriksson , Veronica Profir , Per-Olov Bergstrom
IPC分类号： A61K31/4439 , C07D413/14
CPC分类号： C07D413/14
摘要： The present invention is directed to novel compounds, their use in therapy and pharmaceutical compositions comprising said novel compounds.
摘要翻译： 本发明涉及新化合物，它们在治疗中的用途和包含所述新化合物的药物组合物。
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10.发明申请Additional heteropolycyclic compounds and their use as metabotropic glutamate receptor antagonists 失效额外的杂多环化合物及其作为代谢型谷氨酸受体拮抗剂的用途公开(公告)号：US20050272779A1
公开(公告)日：2005-12-08
申请号：US11053752
申请日：2005-02-09
申请人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
发明人： Louise Edwards , Methvin Isaac , Martin Johansson , Annika Kers , Johan Malmberg , Donald McLeod , Alexander Mindis , Karin Staaf , Abdelmalik Slassi , Tomislav Stefanac , Thomas Stormann , David Wensbo , Tao Xin , Jalaj Arora
IPC分类号： A61K31/4245 , A61K31/4439 , C07D413/14
CPC分类号： C07D487/04 , C07D413/06 , C07D413/12 , C07D413/14
摘要： The present invention relates to new compounds of formula I, to pharmaceutical formulations containing the compounds, and to the use of the compounds in the prevention and/or treatment of mGluR5 receptor-mediated disorders.
摘要翻译： 本发明涉及新的式I化合物，含有该化合物的药物制剂，以及该化合物在预防和/或治疗mGluR5受体介导的病症中的用途。
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