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公开(公告)号：US20100210036A1
公开(公告)日：2010-08-19
申请号：US12768729
申请日：2010-04-28
申请人： James Arnold , Dean R. Artis , Clarence H. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean R. Artis , Clarence H. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
IPC分类号： G01N33/566 , C07D231/56 , C07D209/04 , C07D413/12 , C07D401/12
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译： 描述了对PPARs有活性的化合物，包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号：US08367828B2
公开(公告)日：2013-02-05
申请号：US12768729
申请日：2010-04-28
申请人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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公开(公告)号：US07572806B2
公开(公告)日：2009-08-11
申请号：US12001026
申请日：2007-12-07
申请人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
IPC分类号： A61K31/44 , A61K31/4725 , A61K31/404
CPC分类号： C04B35/632 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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公开(公告)号：US07348338B2
公开(公告)日：2008-03-25
申请号：US10937791
申请日：2004-09-08
申请人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
IPC分类号： A61K31/44 , A61K31/4725 , A61K31/404
CPC分类号： C04B35/632 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
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公开(公告)号：US07202266B2
公开(公告)日：2007-04-10
申请号：US10893134
申请日：2004-07-16
申请人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
IPC分类号： A61K209/08 , C07D209/08
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译： 描述了对PPARs有活性的化合物，包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
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公开(公告)号：US08849577B2
公开(公告)日：2014-09-30
申请号：US11901523
申请日：2007-09-17
CPC分类号： G01N33/5008 , Y10T436/24
摘要： Methods for metabolomically determining the biological affects of compounds are described.
摘要翻译： 描述了代谢组学测定化合物生物学影响的方法。
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公开(公告)号：US20080161228A1
公开(公告)日：2008-07-03
申请号：US11901523
申请日：2007-09-17
CPC分类号： G01N33/5008 , Y10T436/24
摘要： Methods for metabolomically determining the biological affects of compounds are described.
摘要翻译： 描述了代谢组学测定化合物生物学影响的方法。
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