-
公开(公告)号：US20100210036A1
公开(公告)日：2010-08-19
申请号：US12768729
申请日：2010-04-28
申请人： James Arnold , Dean R. Artis , Clarence H. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean R. Artis , Clarence H. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
IPC分类号： G01N33/566 , C07D231/56 , C07D209/04 , C07D413/12 , C07D401/12
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译： 描述了对PPARs有活性的化合物，包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
-
公开(公告)号：US08367828B2
公开(公告)日：2013-02-05
申请号：US12768729
申请日：2010-04-28
申请人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
-
公开(公告)号：US07572806B2
公开(公告)日：2009-08-11
申请号：US12001026
申请日：2007-12-07
申请人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
IPC分类号： A61K31/44 , A61K31/4725 , A61K31/404
CPC分类号： C04B35/632 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
-
公开(公告)号：US07348338B2
公开(公告)日：2008-03-25
申请号：US10937791
申请日：2004-09-08
申请人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
IPC分类号： A61K31/44 , A61K31/4725 , A61K31/404
CPC分类号： C04B35/632 , A61K31/40 , A61K31/405 , A61K31/44 , A61K31/47 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D471/04 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
-
公开(公告)号：US07202266B2
公开(公告)日：2007-04-10
申请号：US10893134
申请日：2004-07-16
申请人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
发明人： James Arnold , Dean R. Artis , Clarence R. Hurt , Prabha N. Ibrahim , Heike Krupka , Jack Lin , Michael V. Milburn , Weiru Wang , Chao Zhang
IPC分类号： A61K209/08 , C07D209/08
CPC分类号： C07D471/04 , C04B35/632 , C07D209/08 , C07D209/12 , C07D209/18 , C07D209/22 , C07D209/26 , C07D231/56 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D487/04
摘要： Compounds are described that are active on PPARs, including pan-active compounds. Also described are methods for developing or identifying compounds having a desired selectivity profile.
摘要翻译： 描述了对PPARs有活性的化合物，包括泛活性化合物。 还描述了用于开发或鉴定具有所需选择性分布的化合物的方法。
-
公开(公告)号：US08053463B2
公开(公告)日：2011-11-08
申请号：US12043069
申请日：2008-03-05
申请人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号： C07D209/04 , C07D401/02 , A61K31/454 , A61K31/404
CPC分类号： C07D401/12 , C07D209/18 , C07D403/12
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ, wherein the compounds have the formula: wherein: X2 and X3 are independently CH or N; and one of X1 and X4 is N or CR4 and the other of X1 and X4 is N or CH.
摘要翻译： 描述了对PPARα，PPARδ和PPARγ中的至少一种有活性的化合物，其可用于涉及调节PPARα，PPARδ和PPARγ中的至少一种的治疗和/或预防方法，其中所述化合物具有下式：其中 ：X2和X3独立地是CH或N; X1和X4之一是N或CR4，X1和X4中的另一个是N或CH。
-
公开(公告)号：US20120015966A1
公开(公告)日：2012-01-19
申请号：US13243703
申请日：2011-09-23
申请人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号： A61K31/506 , C07D401/12 , C07D403/12 , A61K31/405 , A61K31/4439 , A61K31/4155 , A61P3/04 , A61P3/00 , A61P3/06 , A61P3/10 , A61P3/08 , A61P25/00 , A61P13/12 , A61P27/02 , A61P17/02 , A61P13/10 , A61P1/00 , A61P27/12 , A61P9/12 , A61P9/00 , A61P9/04 , A61P9/10 , A61P43/00 , A61P17/00 , A61P37/06 , A61P29/00 , A61P11/06 , A61P11/00 , A61P15/00 , A61P1/18 , A61P1/16 , A61P25/28 , A61P17/06 , A61P25/16 , A61P7/02 , A61P1/04 , A61P13/00 , A61P31/18 , A61P31/14 , A61P31/04 , A61P25/04 , A61P35/00 , C07D209/18
CPC分类号： C07D401/12 , C07D209/18 , C07D403/12
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译： 描述了对PPARα，PPARδ和PPARγ中的至少一种具有活性的化合物，其可用于涉及调节PPARα，PPARδ和PPARγ中的至少一种的治疗和/或预防方法。
-
公开(公告)号：US20080255201A1
公开(公告)日：2008-10-16
申请号：US12043069
申请日：2008-03-05
申请人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人： Jack Lin , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号： A61K31/454 , A61K31/404 , C07D209/04 , A61P3/04 , C07D401/02
CPC分类号： C07D401/12 , C07D209/18 , C07D403/12
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
-
公开(公告)号：US20080249137A1
公开(公告)日：2008-10-09
申请号：US11517572
申请日：2006-09-06
申请人： Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
发明人： Jack Lin , Patrick Womack , Byunghun Lee , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang , Rebecca Zuckerman
IPC分类号： A61K31/44 , C07C235/34 , A61K31/165 , A61K31/192 , A61P3/04 , C07C57/58 , C07D213/64
CPC分类号： C07C317/46 , B82Y15/00 , C07C51/08 , C07C51/09 , C07C59/68 , C07C59/72 , C07C59/90 , C07C61/39 , C07C69/734 , C07C235/34 , C07C235/40 , C07C317/44 , C07C323/20 , C07C323/65 , C07C2601/02 , C07C2601/08 , C07D213/64 , C07D231/12 , C07D231/24 , C07D239/54 , C07D261/08 , C07D263/32 , C07D263/46 , C07D277/24 , C07D277/36 , C07D333/32 , C07D333/34 , G01N33/588 , G01N33/6872 , C07C59/52
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译： 描述了对PPARα，PPARδ和PPARγ中的至少一种具有活性的化合物，其可用于涉及调节PPARα，PPARδ和PPARγ的至少一种的治疗和/或预防方法。
-
公开(公告)号：US20080221127A1
公开(公告)日：2008-09-11
申请号：US12043095
申请日：2008-03-05
申请人： Jack Lin , Patrick Womack , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang
发明人： Jack Lin , Patrick Womack , Shenghua Shi , Chao Zhang , Dean R. Artis , Prabha N. Ibrahim , Weiru Wang
IPC分类号： A61K31/50 , C07C63/00 , A61K31/19 , C07D231/12 , A61K31/415 , A61P3/04 , A61K31/44 , C07D211/86 , C07D239/02
CPC分类号： C07C317/46 , C07C59/68 , C07C317/44 , C07D213/64 , C07D231/12 , C07D239/34
摘要： Compounds are described that are active on at least one of PPARα, PPARδ, and PPARγ, which are useful for therapeutic and/or prophylactic methods involving modulation of at least one of PPARα, PPARδ, and PPARγ.
摘要翻译： 描述了对PPARα，PPARδ和PPARγ中的至少一种具有活性的化合物，其可用于涉及调节PPARα，PPARδ和PPARγ的至少一种的治疗和/或预防方法。
-
-
-
-
-
-
-
-
-
搜索结果
136 条记录 (耗时 0.071 秒)
