公开(公告)号：US20090028798A1

公开(公告)日：2009-01-29

申请号：US11997236

申请日：2006-08-10

申请人： James B. Mitchell ,  Murali K. Cherukuri ,  John A. Cook ,  Fuminori Hyodo ,  Alan P. Koretsky ,  Ken-Ichiro Matsumoto ,  Sankaran Subramanian ,  David A. Wink

发明人： James B. Mitchell ,  Murali K. Cherukuri ,  John A. Cook ,  Fuminori Hyodo ,  Alan P. Koretsky ,  Ken-Ichiro Matsumoto ,  Sankaran Subramanian ,  David A. Wink

IPC分类号： A61K49/08

CPC分类号： A61B5/055 ,  A61K49/10 ,  A61K49/20

摘要： Disclosed is a method for determining the redox status of a region of interest in an animal tissue. The method includes administering a nitroxyl contrast agent to the region of interest, obtaining a magnetic resonance image of the region of interest, determining the amount of reduced nitroxyl contrast agent in the region of interest, and thereby determining the redox status of the region of interest.

摘要翻译： 公开了一种用于确定动物组织中感兴趣区域的氧化还原状态的方法。 该方法包括向感兴趣区域施用硝酰基造影剂，获得感兴趣区域的磁共振图像，确定感兴趣区域中还原的硝酰基造影剂的量，从而确定感兴趣区域的氧化还原状态 。

公开(公告)号：US20120276644A1

公开(公告)日：2012-11-01

申请号：US13504890

申请日：2010-10-29

申请人： Hideo Utsumi ,  Fuminori Hyodo ,  Kazuhiro Ichikawa

发明人： Hideo Utsumi ,  Fuminori Hyodo ,  Kazuhiro Ichikawa

IPC分类号： A61B5/055 ,  G01N24/08

CPC分类号： A61K49/20 ,  G01R33/48 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/60 ,  G01R33/62 ,  Y10T436/141111 ,  Y10T436/142222 ,  Y10T436/200833 ,  Y10T436/24

摘要： Provided is a method for the real-time visualization of an endogenous biomolecule to clarify the mechanisms of various diseases and enable diagnosis and treatment of these diseases. Specifically provided is a novel method for visualizing an endogenous biomolecule by using a magnetic resonance method (including Overhauser MRI and the electron spin resonance method). The aforesaid visualization method, whereby an endogenous biomolecule is visualized on a real-time basis, comprises: a step for treating a living organism to be examined by a magnetic resonance method and thus acquiring data of the endogenous biomolecule; a step for processing the data of the endogenous biomolecule thus obtained to give imaging data; and a step for displaying the imaging data thus obtained.

摘要翻译： 提供了一种内源性生物分子的实时可视化方法，以澄清各种疾病的机制，并能够诊断和治疗这些疾病。 具体提供的是通过使用磁共振法（包括Overhauser MRI和电子自旋共振法）来观察内源性生物分子的新方法。 上述可视化方法，其中内生生物分子在实时的基础上可视化，包括：通过磁共振方法处理待检查的活生物体，从而获取内源性生物分子的数据的步骤; 用于处理由此获得的内源性生物分子的数据以提供成像数据的步骤; 以及用于显示由此获得的成像数据的步骤。

公开(公告)号：US08722420B2

公开(公告)日：2014-05-13

申请号：US13504890

申请日：2010-10-29

申请人： Hideo Utsumi ,  Fuminori Hyodo ,  Kazuhiro Ichikawa

发明人： Hideo Utsumi ,  Fuminori Hyodo ,  Kazuhiro Ichikawa

IPC分类号： G01N24/00

CPC分类号： A61K49/20 ,  G01R33/48 ,  G01R33/485 ,  G01R33/5601 ,  G01R33/60 ,  G01R33/62 ,  Y10T436/141111 ,  Y10T436/142222 ,  Y10T436/200833 ,  Y10T436/24

摘要： Provided is a method for the real-time visualization of an endogenous biomolecule to clarify the mechanisms of various diseases and enable diagnosis and treatment of these diseases. Specifically provided is a novel method for visualizing an endogenous biomolecule by using a magnetic resonance method (including Overhauser MRI and the electron spin resonance method). The aforesaid visualization method, whereby an endogenous biomolecule is visualized on a real-time basis, comprises: a step for treating a living organism to be examined by a magnetic resonance method and thus acquiring data of the endogenous biomolecule; a step for processing the data of the endogenous biomolecule thus obtained to give imaging data; and a step for displaying the imaging data thus obtained.

摘要翻译： 提供了一种内源性生物分子的实时可视化方法，以澄清各种疾病的机制，并能够诊断和治疗这些疾病。 具体提供的是通过使用磁共振法（包括Overhauser MRI和电子自旋共振法）来观察内源性生物分子的新方法。 上述可视化方法，其中内生生物分子在实时的基础上可视化，包括：通过磁共振方法处理待检查的活生物体，从而获取内源性生物分子的数据的步骤; 用于处理由此获得的内源性生物分子的数据以提供成像数据的步骤; 以及用于显示由此获得的成像数据的步骤。