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    Quinazolinone T-type calcium channel antagonists
    3.
    发明授权
    Quinazolinone T-type calcium channel antagonists 有权
    喹唑啉酮T型钙通道拮抗剂

    公开(公告)号：US07745452B2

    公开(公告)日：2010-06-29

    申请号：US11886053

    申请日：2006-03-08

    申请人： James C. Barrow ,  Rowena V. Cube ,  Phung Le Ngo ,  Kenneth E. Rittle ,  Zhiqiang Yang ,  Steven D. Young

    发明人： James C. Barrow ,  Rowena V. Cube ,  Phung Le Ngo ,  Kenneth E. Rittle ,  Zhiqiang Yang ,  Steven D. Young

    IPC分类号： C07D473/00

    CPC分类号： C07D239/82 ,  C07D401/06 ,  C07D405/06

    摘要： The present invention is directed to quinazolinone compounds of the formula I: wherein R1, R2, R3, X1, X2 X3 are defined herein. These compounds are antagonists of T-type calcium channels, and are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels are involved.

    摘要翻译： 本发明涉及式I的喹唑啉酮化合物：其中R 1，R 2，R 3，X 1，X 2 X 3在本文中定义。 这些化合物是T型钙通道的拮抗剂，可用于治疗或预防涉及T型钙通道的疾病和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及T型钙通道的疾病中的用途。

    HIV integrase inhibitors
    6.
    发明授权
    HIV integrase inhibitors 失效
    HIV整合酶抑制剂

    公开(公告)号：US06262055B1

    公开(公告)日：2001-07-17

    申请号：US09323457

    申请日：1999-06-01

    申请人： Steven D. Young ,  John S. Wai ,  Mark W. Embrey ,  Thorsten E. Fisher

    发明人： Steven D. Young ,  John S. Wai ,  Mark W. Embrey ,  Thorsten E. Fisher

    IPC分类号： A61K31495

    CPC分类号： C07D409/12 ,  C07D277/42 ,  C07D333/24 ,  C07D333/32 ,  C07D333/34 ,  C07D333/36 ,  C07D333/60 ,  C07D333/74

    摘要： Sulfur-containing heteroaryl dioxo-butyric acid derivatives are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

    摘要翻译： 含硫杂芳基二氧代丁酸衍生物被描述为HIV整合酶的抑制剂和HIV复制抑制剂。 这些化合物可用于预防或治疗HIV的感染和治疗AIDS，无论是化合物，药学上可接受的盐，药物组合物成分，无论是否与其他抗病毒药，免疫调节剂，抗生素或疫苗结合使用。 还描述了治疗艾滋病的方法和预防或治疗HIV感染的方法。

    Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors
    10.
    发明授权
    Hydroxynaphthyridinone carboxamides useful as HIV integrase inhibitors 失效
    可用作HIV整合酶抑制剂的羟基萘啶酮甲酰胺

    公开(公告)号：US07279487B2

    公开(公告)日：2007-10-09

    申请号：US10500972

    申请日：2003-01-13

    申请人： Melissa Egbertson ,  Jeffrey Y. Melamed ,  H. Marie Langford ,  Steven D. Young

    发明人： Melissa Egbertson ,  Jeffrey Y. Melamed ,  H. Marie Langford ,  Steven D. Young

    IPC分类号： A61K31/44 ,  C07F5/02 ,  C07D471/02

    CPC分类号： C07D471/04 ,  A61K31/4353 ,  A61K45/06 ,  A61K2300/00

    摘要： Hydroxynaphthyridinone carboxamides of formula: are described as inhibitors of HIV integrase and inhibitors of HIV replication, wherein L, R1a, R1b, R1c, R2a, R2b, R3, R4, and R5 are defined herein. These compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of preventing, treating or delaying the onset of AIDS and methods of preventing or treating infection by HIV are also described.

    摘要翻译： 下式的羟基萘啶酮甲酰胺被描述为HIV整合酶的抑制剂和HIV复制抑制剂，其中L，R 1a，R 1b，R 1c， R 2a，R 2b，R 3，R 4和R 5，以及R 5， >在本文中定义。 这些化合物可用于预防和治疗艾滋病毒感染以及艾滋病的预防，延迟发作和治疗。 这些化合物用作抗感染和艾滋病作为化合物本身或以药学上可接受的盐的形式。 化合物及其盐可以用作药物组合物中的成分，任选与其它抗病毒剂，免疫调节剂，抗生素或疫苗组合使用。 还描述了预防，治疗或延缓AIDS发病的方法以及预防或治疗HIV感染的方法。