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1.发明授权Method and reagent for treatment of diseases by expression of the c-Myc gene 失效通过c-Myc基因表达治疗疾病的方法和试剂公开(公告)号：US06544755B1
公开(公告)日：2003-04-08
申请号：US08192943
申请日：1994-02-07
IPC分类号： C07H2104
CPC分类号： C12N15/113 , C12N15/1135 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of Burkitt's lymphoma or acute lymphocytic leukemia.
摘要翻译： 一种酶切RNA分子，其切割与发展或维持伯基特氏淋巴瘤或急性淋巴细胞性白血病相关的mRNA。
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2.发明授权Method and reagent for treatment of diseases caused by expression of the bcl-2 gene 失效用于治疗由bcl-2基因表达引起的疾病的方法和试剂
公开(公告)号：US5750390A
公开(公告)日：1998-05-12
申请号：US936421
申请日：1992-08-26
IPC分类号： C12N15/113 , C12N15/10
CPC分类号： C12N15/113 , C12N15/1135 , C12N15/1138 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126
摘要： An enzymatic RNA molecule which cleaves bcl.2 mRNA associated with development or maintenance of follicular lymphoma.
摘要翻译： 裂解与发育或维持滤泡淋巴瘤相关的bcl.2 mRNA的酶促RNA分子。
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3.发明授权
公开(公告)号：US6159692A
公开(公告)日：2000-12-12
申请号：US249215
申请日：1999-02-12
IPC分类号： A61K38/00 , C07K14/08 , C12N15/113 , C12N15/85 , C12N15/86 , C12Q1/70 , C12Q1/68 , C07H21/04 , C12N15/63
CPC分类号： C12N15/1132 , A61K38/00 , C07K14/005 , C12N15/85 , C12N15/86 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2740/16022 , C12Q1/701 , C12Q1/703
摘要： An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
摘要翻译： 在病毒复制所需的基因中切割免疫缺陷病毒RNA的酶学核酸分子，例如nef或tat基因区域。
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公开(公告)号：US5599704A
公开(公告)日：1997-02-04
申请号：US435350
申请日：1995-05-05
IPC分类号： C12N15/113 , C07H21/04 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/113 , C12N15/1135 , C12N15/1138 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of breast cancer.
摘要翻译： 一种酶切RNA分子，其切割与乳腺癌发展或维持相关的mRNA。
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公开(公告)号：US5610052A
公开(公告)日：1997-03-11
申请号：US936110
申请日：1992-08-26
IPC分类号： C12N15/113 , C12N5/00 , C07H21/04
CPC分类号： C12N15/113 , C12N15/1135 , C12N15/1138 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of colon carcinoma.
摘要翻译： 一种酶切RNA分子，其切割与结肠癌发展或维持相关的mRNA。
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6.发明授权Method and reagent for treatment of lung cancer and other malignancies caused by the deregulation of L-MYC gene expression 失效用于治疗由L-MYC基因表达失调引起的肺癌和其他恶性肿瘤的方法和试剂公开(公告)号：US06492512B1
公开(公告)日：2002-12-10
申请号：US07936532
申请日：1992-08-26
IPC分类号： C07H2102
CPC分类号： C12N15/113 , C12N15/1135 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of lung cancer.
摘要翻译： 切割与肺癌发展或维持相关的mRNA的酶RNA分子。
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公开(公告)号：US5972704A
公开(公告)日：1999-10-26
申请号：US910408
申请日：1997-08-13
IPC分类号： A61K38/00 , C07K14/08 , C12N15/113 , C12N15/85 , C12N15/86 , C12Q1/70 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/1132 , C07K14/005 , C12N15/85 , C12N15/86 , C12Q1/701 , C12Q1/703 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2740/16022
摘要： An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
摘要翻译： 在病毒复制所需的基因中切割免疫缺陷病毒RNA的酶学核酸分子，例如nef或tat基因区域。
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公开(公告)号：US5801158A
公开(公告)日：1998-09-01
申请号：US777918
申请日：1996-12-23
IPC分类号： C12N15/113 , C12Q1/68 , A61K48/00 , C07H21/02 , C12N5/08
CPC分类号： C12N15/113 , C12N15/1135 , C12N15/1138 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of colon carcinoma.
摘要翻译： 一种酶切RNA分子，其切割与结肠癌发展或维持相关的mRNA。
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公开(公告)号：US5693535A
公开(公告)日：1997-12-02
申请号：US271880
申请日：1994-07-07
IPC分类号： A61K38/00 , C07K14/08 , C12N15/113 , C12N15/85 , C12N15/86 , C12Q1/70 , C12N15/83 , C12Q1/68
CPC分类号： C12N15/1132 , C07K14/005 , C12N15/85 , C12N15/86 , C12Q1/701 , C12Q1/703 , A61K38/00 , C12N2310/12 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3521 , C12N2310/3531 , C12N2310/3533 , C12N2310/3535 , C12N2740/16022
摘要： An enzymatic nucleic acid molecule which cleaves an immunodeficiency virus RNA in a gene required for viral replication, e.g., the nef or tat gene regions.
摘要翻译： 在病毒复制所需的基因中切割免疫缺陷病毒RNA的酶学核酸分子，例如nef或tat基因区域。
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公开(公告)号：US5639655A
公开(公告)日：1997-06-17
申请号：US233030
申请日：1994-04-25
CPC分类号： C12N15/113 , C12N15/1135 , C12N15/1138 , A61K38/00 , C12N2310/111 , C12N2310/121 , C12N2310/122 , C12N2310/123 , C12N2310/124 , C12N2310/126 , C12N2310/53
摘要： An enzymatic RNA molecule which cleaves mRNA associated with development or maintenance of promyelocytic leukemia.
摘要翻译： 一种酶切RNA分子，其切割与前髓细胞白血病发育或维持相关的mRNA。
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