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23 条记录 (耗时 0.023 秒)

    Immunoliposome-Nucleic Acid Amplification (ILNAA) Assay
    5.
    发明申请
    Immunoliposome-Nucleic Acid Amplification (ILNAA) Assay 失效
    免疫脂质体 - 核酸扩增（ILNAA）测定

    公开(公告)号：US20090176250A1

    公开(公告)日：2009-07-09

    申请号：US12399060

    申请日：2009-03-06

    申请人： Timothy J. O'Leary ,  Jeffrey T. Mason

    发明人： Timothy J. O'Leary ,  Jeffrey T. Mason

    IPC分类号： G01N33/53

    CPC分类号： A61K9/127 ,  C12Q1/6806 ,  C12Q2563/161

    摘要： Immunoliposomes and use thereof in highly specific and sensitive nucleic acid amplification assays relying on amplification of specific nucleic acid sequences released from encapsulation within a liposome after a receptor on the liposome couples with a targeted analyte/antigen immobilized on a select surface. The immunoliposome nucleic acid amplification assay permits both quantitative and qualitative analyte detection.

    摘要翻译： 免疫脂质体及其在高度特异性和灵敏的核酸扩增测定中的应用，其依赖于在脂质体上的受体之后从脂质体中的包封释放的特异性核酸序列的扩增与固定在选择表面上的靶向分析物/抗原相结合。 免疫脂质体核酸扩增测定允许定量和定性分析物检测。

    Method of applying a hot melt coating
    6.
    发明授权
    Method of applying a hot melt coating 失效
    施加热熔涂层的方法

    公开(公告)号：US5747107A

    公开(公告)日：1998-05-05

    申请号：US548897

    申请日：1995-10-26

    申请人： Glen H. Bayer, Jr. ,  Timothy J. O'Leary

    发明人： Glen H. Bayer, Jr. ,  Timothy J. O'Leary

    IPC分类号： B05D1/26 ,  B05C1/08 ,  D21H23/56 ,  B05D5/10

    CPC分类号： B32B37/153 ,  B05C1/0813 ,  B05C1/083 ,  B32B37/1284 ,  D21H23/56 ,  B32B2037/1215 ,  B32B2317/12

    摘要： A method of applying a coating of hot melt polymeric material from a die to a substrate. Hot melt polymeric material is extruded through the die onto the peripheral surface of a rotating application roller to provide a coating layer along that peripheral surface. A substrate is conveyed past the peripheral surface of the application roller at an application interface to cause transfer of the first coating layer to the substrate and shearing and thinning of the coating layer because the substrate is conveyed faster than the peripheral speed of the application roller. The velocity of the peripheral surface and spacing between the die and the application interface along are selected to provide a time interval of at least 0.12 second for movement of portions of the coating layer from the die to the application interface, thereby affording relaxation and molecular reorientation of the hot melt polymeric material after the extruding step to facilitate shearing of the first coating layer at the application interface without causing ribbing or breaking of the coating layer.

    摘要翻译： 将热熔聚合物材料的涂层从模具施加到基底上的方法。 将热熔聚合物材料通过模具挤出到旋转施加辊的外围表面上，以沿着该外围表面提供涂层。 衬底在应用界面处被传送通过施加辊的外周表面，从而使第一涂层转移到衬底上，并且由于衬底的输送速度比施加辊的圆周速度更快，所以涂层的剪切和变薄。 选择周边表面的速度和模具与应用界面之间的间距，以提供至少0.12秒的时间间隔，用于将涂层的一部分从模具移动到施加界面，由此提供松弛和分子重新取向 的挤出步骤之后的热熔聚合物材料，以便于施加界面处的第一涂层的剪切，而不会引起涂层的破裂或破裂。

    Automatic surface profiling for submicron device
    7.
    发明授权
    Automatic surface profiling for submicron device 失效
    亚微米器件的自动表面轮廓

    公开(公告)号：US5528033A

    公开(公告)日：1996-06-18

    申请号：US413070

    申请日：1995-03-29

    申请人： Jiann-Chang Lo ,  Timothy J. O'Leary

    发明人： Jiann-Chang Lo ,  Timothy J. O'Leary

    IPC分类号： G01B11/02 ,  G01B7/34 ,  G01B11/26 ,  G01B21/30 ,  G01Q30/04 ,  G01Q30/06 ,  G01Q60/38 ,  H01J37/00 ,  H01J37/26

    CPC分类号： G01Q60/38 ,  B82Y35/00 ,  G01B7/34 ,  G01Q30/04 ,  G01Q30/06 ,  Y10S977/839 ,  Y10S977/85 ,  Y10S977/852 ,  Y10S977/863

    摘要： A method for automatically providing a surface profile analysis of a submicron device using a microscope system typically used to measure critical dimensions of the submicron device is disclosed. The method generates a data point array that is linearly interpolated along a particular scan line measured. The system then calculates an angle for performing a rotational correlation then rotates the measurement profile from the scan line to an absolute horizontal position based on this rotational correlation angle. Next, the system separates the scan line into independent subset features having line and trench features. The number of these line and trench features are then determined in the scan line and using the data point array, the system then calculates the height, width, and angle for each subset feature in that scan line.

    摘要翻译： 公开了一种用于使用通常用于测量亚微米器件的临界尺寸的显微镜系统自动提供亚微米器件的表面轮廓分析的方法。 该方法产生沿所测量的特定扫描线线性内插的数据点阵列。 然后，该系统计算用于执行旋转相关的角度，然后基于该旋转相关角度将测量轮廓从扫描线旋转到绝对水平位置。 接下来，系统将扫描线分成具有线和沟槽特征的独立子集特征。 然后在扫描线中确定这些线和沟槽特征的数量，并使用数据点阵列，系统然后计算该扫描线中每个子集特征的高度，宽度和角度。

    ATTACHMENT SYSTEM
    8.
    发明申请
    ATTACHMENT SYSTEM 审中-公开
    附件系统

    公开(公告)号：US20120321852A1

    公开(公告)日：2012-12-20

    申请号：US13592681

    申请日：2012-08-23

    申请人： Douglas P. Bodziak ,  Jemes E. Nash ,  Peter Newbould ,  Timothy J. O'Leary ,  David C. Windorski

    发明人： Douglas P. Bodziak ,  Jemes E. Nash ,  Peter Newbould ,  Timothy J. O'Leary ,  David C. Windorski

    IPC分类号： B32B3/10

    摘要： A dispenser includes an upper member having a slot and a lower member attached to the upper member thereby forming a housing, the lower member having an outer surface; a stack of sheets assembled in a fan-fold configuration disposed in the housing; and a polymeric holding film having a first surface attached to the outer surface of the lower member. The holding film having a flexural modulus less than about 50 MPa, as measured according to ASTMD790 standard, and a roughness parameter, Ra of less than about 1 micrometer, as calculated according to ASME B46.1 standard.

    摘要翻译： 分配器包括具有狭槽的上部构件和附接到所述上部构件的下部构件，从而形成壳体，所述下部构件具有外表面; 堆叠的薄片组装成设置在壳体中的扇形折叠结构; 以及具有附接到下部构件的外表面的第一表面的聚合物保持膜。 根据ASTMD790标准测量的弯曲模量小于约50MPa的保持膜和根据ASME B46.1标准计算的粗糙度参数Ra小于约1微米。

    Dispenser package
    9.
    发明授权
    Dispenser package 有权
    分配器包装

    公开(公告)号：US07494027B2

    公开(公告)日：2009-02-24

    申请号：US11341293

    申请日：2006-01-27

    申请人： Timothy J. O'Leary ,  Scott A. Willard ,  James R. Emmerling

    发明人： Timothy J. O'Leary ,  Scott A. Willard ,  James R. Emmerling

    IPC分类号： B65H1/00

    CPC分类号： B42D5/005 ,  B65D83/0805

    摘要： A dispenser package for dispensing flexible sheets from a plurality of stacks of releasably adhered sheets. A carrier member supports the plurality of stacks, and a lowermost sheet of each of the plurality of stacks is adhered to the carrier member. The carrier member and stacks thereon are positioned within an enclosure having a bottom wall, a top wall, and transverse side walls. The top wall defines a transverse slot, with a first end of an uppermost sheet of each of the plurality of stacks projecting through the slot. The transverse side walls of the enclosure are spaced from transverse side edges of the carrier member to afford end-to-end movement of the carrier member and stacks of sheets thereon within the chamber as sheets are dispensed.

    摘要翻译： 一种分配器包装，用于从可释放地粘附的片材的多个堆叠中分配柔性片材。 载体构件支撑多个堆叠，并且多个堆叠中的每一个的最下面的片材粘附到载体构件。 载体构件和其上的叠层位于具有底壁，顶壁和横向侧壁的外壳内。 顶壁限定横向槽，多个堆叠中的每一个的最上面的板的第一端通过槽突出。 外壳的横向侧壁与承载构件的横向侧边缘间隔开，以便在分配片材时在载体构件和其中的片材堆叠之间提供端对端运动。