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公开(公告)号：US5458568A
公开(公告)日：1995-10-17
申请号：US123374
申请日：1993-09-17
CPC分类号： A61M25/104 , A61M16/0481 , A61M37/0092 , A61N1/05 , A61N1/306 , A61N1/325 , A61M2025/0057 , A61M2025/105 , A61N2001/0585
摘要： A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively wetting a membrane within the device, making the membrane permeable and allowing transport of a drug across the membrane and into the passageway wall or body tissue.
摘要翻译： 一种用于将药物局部递送到内部身体组织的药物递送装置和方法。 本发明考虑将药物递送装置定位在身体通道或身体组织内，然后选择性地润湿装置内的膜，使得膜可渗透并允许药物穿过膜并进入通道壁或身体组织。
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公开(公告)号：US5282785A
公开(公告)日：1994-02-01
申请号：US956789
申请日：1992-10-05
CPC分类号： A61M25/104 , A61M16/0481 , A61M29/02 , A61M37/0092 , A61N1/05 , A61N1/306 , A61N1/325 , A61M2025/0057 , A61M2025/105 , A61N2001/0585
摘要： A drug delivery apparatus and method for delivering a drug locally to internal body tissue. The invention contemplates positioning a drug delivery device in a body passageway or within body tissue and then selectively introducing a selected drug so that it is transported across a drug transport wall of the device for direct contact with the passageway wall or body tissue. A further aspect of the present invention involves treating a dilated vessel in the area of a stenotic lesion with a fixative or other drug to render the vessel biologically inert and to form a biological stent or prevent restenosis using specifically selected drugs. A still further aspect of the present invention involves treating a tumor or local or regional tissue mass with antitumor sensitizing agents, biological modifiers, antibiotics or other types of drugs by delivery of the drug to the tumor or tissue area directly or through the passageway wall.
摘要翻译： 一种用于将药物局部递送到内部身体组织的药物递送装置和方法。 本发明考虑将药物递送装置定位在身体通道或身体组织内，然后选择性地引入所选择的药物，使得其被输送穿过装置的药物输送壁，以与通道壁或身体组织直接接触。 本发明的另一方面涉及用固定剂或其它药物在狭窄病变区域中处理扩张的血管，使血管生物学惰性并形成生物支架，或使用特定选择的药物预防再狭窄。 本发明的另一方面涉及通过将药物直接或通过通道壁递送到肿瘤或组织区域，用抗肿瘤敏化剂，生物改良剂，抗生素或其它类型的药物来治疗肿瘤或局部或区域组织块。
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公开(公告)号：US5865787A
公开(公告)日：1999-02-02
申请号：US710146
申请日：1996-09-13
CPC分类号： A61M25/104 , A61M31/002 , A61N1/306 , A61N1/325 , A61N1/362 , A61M2025/0057
摘要： An apparatus and method for delivering a drug selectively and locally to internal body tissue with a catheter using electric current/voltage controlled in conjunction with active pacing of cardiac activity.
摘要翻译： 用于使用电流/电压与心脏活动的主动起搏一起控制的导管，使用导管将药物选择性地和局部地输送到内部身体组织的装置和方法。
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公开(公告)号：US5634899A
公开(公告)日：1997-06-03
申请号：US177175
申请日：1994-01-04
CPC分类号： A61M25/104 , A61M31/002 , A61N1/306 , A61N1/325 , A61N1/362 , A61M2025/0057
摘要： An apparatus and method for delivering a drug selectively and locally to internal body tissue with a catheter using electric current/voltage controlled in conjunction with active pacing of cardiac activity.
摘要翻译： 用于使用电流/电压与心脏活动的主动起搏一起控制的导管，使用导管将药物选择性地和局部地输送到内部身体组织的装置和方法。
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公开(公告)号：US20090202604A1
公开(公告)日：2009-08-13
申请号：US12426031
申请日：2009-04-17
IPC分类号： A61F13/00 , A61K31/551
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。
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公开(公告)号：US08940315B2
公开(公告)日：2015-01-27
申请号：US12426031
申请日：2009-04-17
CPC分类号： A61K31/197 , A61K9/0024 , A61K47/34
摘要： Effective treatments of pain for extended periods of time are provided. The treatments include the administration of one or more drug depots intraspinally wherein the drug depots include an effective amount of a benzodiazepine, such as midazolam, formulated within a polyorthoester. By administration of one or more drug depots, one can relieve pain caused by diverse sources, including but not limited to chronic pelvic pain syndromes, spinal disc herniation (i.e. sciatica), spondilothesis, stenosis, discongenic back pain and joint pain, as well as pain that is incidental to surgery. In some embodiments, the relief can be for at least twenty-five days, at least fifty days, at least one hundred days or at least one hundred and thirty-five days.
摘要翻译： 提供长时间有效的疼痛治疗。 治疗方法包括给药一种或多种药物贮库，其中药物贮库包括配制在聚原酸酯内的有效量的苯二氮卓类，如咪达唑仑。 通过管理一个或多个药物库，可以减轻由多种来源引起的疼痛，包括但不限于慢性盆腔疼痛综合征，椎间盘突出症（即坐骨神经痛），脊椎脱位，狭窄，恶性背痛和关节疼痛，以及 手术附带的疼痛。 在一些实施方案中，缓解可以是至少二十五天，至少五十天，至少一百天或至少一百三十五天。
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7.发明申请ALPHA ADRENERGIC RECEPTOR AGONISTS FOR TREATMENT OF INFLAMMATORY DISEASES 有权治疗炎症性疾病的ALPHA ADRENERGIC RECEPTOR AGONISTS公开(公告)号：US20090263450A1
公开(公告)日：2009-10-22
申请号：US12422624
申请日：2009-04-13
申请人： John Myers ZANELLA , William F. McKay , Vanja Margareta King , Christopher M. Hobot , Keith R. Hildebrand
发明人： John Myers ZANELLA , William F. McKay , Vanja Margareta King , Christopher M. Hobot , Keith R. Hildebrand
IPC分类号： A61K31/4168 , A61F2/00 , A61P25/00 , A61P29/00
CPC分类号： A61K31/137 , A61K9/0024 , A61K9/14 , A61K31/415 , A61K31/4162
摘要： Effective treatments of pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease are provided. Through the administration of an effective amount of at least one alpha adrenergic agonist at or near a target site, one can reduce, prevent or treat pain and/or inflammation from tendonitis, carpal tunnel syndrome, tarsal tunnel syndrome, osteoarthritis, bursitis and/or an oral-facial disease.
摘要翻译： 提供了对肌腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或口腔面部疾病的疼痛和/或炎症的有效治疗。 通过在目标部位处或附近施用有效量的至少一种α肾上腺素能激动剂，可以减少，预防或治疗由腱炎，腕管综合征，t疮综合征，骨关节炎，滑囊炎和/或 口腔疾病。
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8.发明授权公开(公告)号：US07390311B2
公开(公告)日：2008-06-24
申请号：US10903599
申请日：2004-07-30
IPC分类号： A61M31/00
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2230/00 , A61M2230/04 , A61M2230/63 , A61N1/3962
摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).
摘要翻译： 由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。 药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。 患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。 交感神经心血管药物是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西汀，脱甲基丸，美托咪定和 右美托咪定）。
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公开(公告)号：US5419763A
公开(公告)日：1995-05-30
申请号：US177332
申请日：1994-01-04
申请人： Keith R. Hildebrand
发明人： Keith R. Hildebrand
CPC分类号： A61M25/1011 , A61B2017/00274 , A61B2018/00547 , A61M2025/0175
摘要： A method and apparatus for the treatment of a prostate gland which isolates the prostatic urethra from the membranous urethra and the bladder so that fluid may be transported into the prostatic ducts without compromising the openings to the prostatic ducts. One preferred embodiment incorporates balloons located at either end of the prostatic urethra to isolate the same.
摘要翻译： 用于治疗前列腺的方法和装置，其将前列腺尿道与膜尿道和膀胱分离，使得流体可以被输送到前列腺管中而不损害前列腺导管的开口。 一个优选实施例包括位于前列腺尿道的任一端的气囊以将其隔离。
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10.发明授权公开(公告)号：US08956636B2
公开(公告)日：2015-02-17
申请号：US12388635
申请日：2009-02-19
申请人： Amira Wohabrebbi , William F. McKay , Christopher M. Hobot , Keith R. Hildebrand , Edward Phillip McDonald
发明人： Amira Wohabrebbi , William F. McKay , Christopher M. Hobot , Keith R. Hildebrand , Edward Phillip McDonald
CPC分类号： A61K31/407 , A61K9/0024 , A61K9/1647 , A61K49/0404 , A61K49/0419
摘要： Methods and compositions are provided for reducing, treating or preventing postoperative pain or inflammation in a patient in need of such treatment, the methods and compositions comprising administering one or more biodegradable drug depots comprising a therapeutically effective amount of ketorolac or pharmaceutically acceptable salt thereof to a target tissue site, wherein the drug depot releases an effective amount of ketorolac or pharmaceutically acceptable salt thereof over a period of 3 to 10 days.
摘要翻译： 提供了用于在需要这种治疗的患者中减少，治疗或预防术后疼痛或炎症的方法和组合物，所述方法和组合物包括给予包含治疗有效量的酮咯酸或其药学上可接受的盐的一种或多种可生物降解的药物宿主 靶组织部位，其中药物库在3至10天的时间内释放有效量的酮咯酸或其药学上可接受的盐。
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