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    COMPOUNDS FOR USE IN CANCER THERAPY
    1.
    发明申请
    COMPOUNDS FOR USE IN CANCER THERAPY 有权
    用于癌症治疗的化合物

    公开(公告)号：US20150065531A1

    公开(公告)日：2015-03-05

    申请号：US14239294

    申请日：2012-08-15

    Applicant: James R. Connor ,  Sang Yong Lee ,  Thomas James Brown ,  Phillip Martin Cowley

    Inventor： James R. Connor ,  Sang Yong Lee ,  Thomas James Brown ,  Phillip Martin Cowley

    IPC: C07D405/06 ,  C07D403/06 ,  C07D401/06 ,  C07D239/60

    CPC classification number: C07D405/06 ,  A61K31/513 ,  C07D239/60 ,  C07D401/06 ,  C07D403/06

    Abstract: Provided are methods and compositions for use in therapy, and in particular for treating cancer, preferably drug-resistant cancer, and/or radiation resistant cancer. The compounds may be used for reducing tumor size in a mammalian subject and for inducing apoptosis in a tumor cell. The methods are effective on tumor cells that are resistant to drugs such as temozolomide, doxorubicin, and geldanamycin, as well as non-resistant tumor cells. Further provided are barbiturate and thiobarbiturates diene compounds for use in treating cancer, and uses, methods and compositions relating to these compounds.

    Abstract translation: 提供了用于治疗，特别是用于治疗癌症，优选耐药性癌症和/或耐辐射癌症的方法和组合物。 所述化合物可用于减少哺乳动物受试者的肿瘤大小并诱导肿瘤细胞凋亡。 该方法对对诸如替莫唑胺，多柔比星和格尔德霉素的药物以及非抗性肿瘤细胞具有抗药性的肿瘤细胞是有效的。 还提供了用于治疗癌症的巴比妥酸盐和硫代巴比妥酸盐二烯化合物，以及与这些化合物有关的用途，方法和组合物。

    Use of ferritin to treat iron disorders
    4.
    发明授权
    Use of ferritin to treat iron disorders 有权
    使用铁蛋白治疗铁病

    公开(公告)号：US08778878B2

    公开(公告)日：2014-07-15

    申请号：US13114429

    申请日：2011-05-24

    Applicant: James R. Connor ,  Ralph Lauren Keil

    Inventor： James R. Connor ,  Ralph Lauren Keil

    IPC: A61K38/00 ,  C12N15/09

    CPC classification number: A61K45/06 ,  A61K33/26 ,  A61K38/1709 ,  C07K14/47 ,  C07K16/18 ,  A61K2300/00

    Abstract: Methods and compositions for treating an iron disorder in a patient are presented, including methods for delivering a therapeutically effective amount of iron to the brain. Iron disorders that may be treated by these methods include iron deficiency disorders and iron overload disorders. A recombinant yeast expressing human H-ferritin and a composition for treating an iron disorder comprising this recombinant yeast are also presented.

    Abstract translation: 提供了用于治疗患者中铁紊乱的方法和组合物，包括将治疗有效量的铁递送至脑的方法。 可能通过这些方法治疗的铁疾病包括缺铁障碍和铁超负荷障碍。 还提供了表达人H-铁蛋白的重组酵母和用于治疗包含该重组酵母的铁病症的组合物。

    Use of ferritin to treat iron deficiency disorders
    5.
    发明授权
    Use of ferritin to treat iron deficiency disorders 有权
    使用铁蛋白治疗铁缺乏症

    公开(公告)号：US08071542B2

    公开(公告)日：2011-12-06

    申请号：US12021922

    申请日：2008-01-29

    Applicant: James R. Connor ,  Ralph Lauren Keil

    Inventor： James R. Connor ,  Ralph Lauren Keil

    IPC: A61K38/00

    CPC classification number: A61K38/1709 ,  A61K33/26

    Abstract: The present inventors have demonstrated the presence of H-ferritin receptors on endothelial cells in culture and on rat brain rat brain microvasculature, identifying H-ferritin as a means for transporting iron across the blood brain barrier. The present invention provides a method for treating an iron deficiency disorder in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a ferritin-iron complex. In an embodiment of the invention, the ferritin-iron complex comprises H-ferritin. In another embodiment, the iron deficiency disorder comprises an iron deficiency in the brain. The present invention also provides a method for delivering iron to the brain, comprising administering iron in the form of a ferritin-iron complex to a patient, whereby said iron is transported across the blood-brain barrier and delivered to the brain; a method for using H-ferritin as a targeting moiety, comprising attaching H-ferritin to a liposome, whereby said liposome is targeted to the brain and/or cells within the brain; and a method for treating an iron overload disorder in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of a multi subunit ferritin complex, wherein said multi subunit ferritin complex is at less than 100% iron binding capacity.

    Abstract translation: 本发明人已经证明在培养物和大鼠脑大鼠脑微血管系统中的内皮细胞上存在H-铁蛋白受体，鉴定H-铁蛋白作为在血脑屏障上传输铁的手段。 本发明提供了一种治疗患者的缺铁性障碍的方法，包括向有需要的患者施用治疗有效量的铁蛋白 - 铁络合物。 在本发明的一个实施方案中，铁蛋白 - 铁络合物包含H-铁蛋白。 在另一个实施方案中，缺铁症包括脑缺铁。 本发明还提供了将铁递送至脑的方法，包括向患者施用铁蛋白 - 铁复合物形式的铁，由此将所述铁转运穿过血脑屏障并输送至脑; 一种使用H-铁蛋白作为靶向部分的方法，包括将H-铁蛋白附着到脂质体上，由此所述脂质体靶向脑内和/或脑内的细胞; 以及用于治疗患者铁过载障碍的方法，包括向有需要的患者施用治疗有效量的多亚基铁蛋白复合物，其中所述多亚基铁蛋白复合物的铁结合能力小于100％。

    FERRITIN AS A THERAPEUTIC TARGET IN ABNORMAL CELLS
    6.
    发明申请
    FERRITIN AS A THERAPEUTIC TARGET IN ABNORMAL CELLS 审中-公开
    FERRITIN作为异常细胞中的治疗目标

    公开(公告)号：US20090280166A1

    公开(公告)日：2009-11-12

    申请号：US12422709

    申请日：2009-04-13

    Applicant: James R. Connor ,  Nodar Surguladze

    Inventor： James R. Connor ,  Nodar Surguladze

    IPC: A61K9/127 ,  A61P35/00 ,  A61K31/7105

    CPC classification number: C12N15/113 ,  C12N15/111 ,  C12N2310/14 ,  C12N2320/31

    Abstract: Compositions for treatment of iron related diseases comprise an inhibitor of ferritin. An inhibitor of ferritin is active to reduce the level of H ferritin protein in a cell and/or to reduce the activity of H ferritin in a cell. Compositions providing cytoprotection, regulation of iron, increasing longevity and viability of cells are described.

    Abstract translation: 用于治疗铁相关疾病的组合物包含铁蛋白抑制剂。 铁蛋白抑制剂是有活性的以降低细胞中H铁蛋白的水平和/或降低细胞中H铁蛋白的活性。 描述了提供细胞保护，铁调节，细胞寿命延长和生存能力的组合物。

    System and method for electroslag welding an expansion joint rail
    8.
    发明授权
    System and method for electroslag welding an expansion joint rail 失效
    用于电焊焊接膨胀节轨的系统和方法

    公开(公告)号：US07038159B2

    公开(公告)日：2006-05-02

    申请号：US10712390

    申请日：2003-11-12

    Applicant: William L. Bong ,  Stephen E. Toy ,  James R. Connor

    Inventor： William L. Bong ,  Stephen E. Toy ,  James R. Connor

    IPC: B23K9/18

    CPC classification number: B23K11/046 ,  B23K2101/26

    Abstract: A system for butt welding expansion joint rails with an electroslag welding system. The electroslag welding system for butt welding the expansion joint rails comprises a control system. The method for butt welding the two expansion joint rails with the electroslag welding system comprises defining a weld cavity with a first expansion joint rail, a second expansion joint rail, a plurality of gland shoes, and a pair of butt shoes. The electroslag welding system can also be adapted to weld a expansion joint rail to a support beam. The method for welding the expansion joint rail to the support beam comprising placing the expansion joint rail on a horizontal axis, placing the support beam on a vertical axis and clamping a modular component system to the expansion joint rail.

    Abstract translation: 一种用电渣焊接系统对接膨胀接头导轨的系统。 用于对接膨胀接头导轨的电渣焊接系统包括控制系统。 利用电渣焊接系统对接两个膨胀接头轨道的方法包括：用第一膨胀接头轨道，第二伸缩接头轨道，多个压盖鞋和一对对接鞋来限定焊接腔。 电渣焊接系统还可以适用于将膨胀节焊接焊接到支撑梁上。 将膨胀接头轨道焊接到支撑梁上的方法，包括将膨胀接头轨道放置在水平轴线上，将支撑梁放置在垂直轴线上，并将模块化部件系统夹紧到膨胀接合轨道。

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