公开(公告)号：US07589209B2

公开(公告)日：2009-09-15

申请号：US11086987

申请日：2005-03-23

申请人： James W. Canary ,  Maksim Royzen

发明人： James W. Canary ,  Maksim Royzen

IPC分类号： C07D215/38

CPC分类号： C07D401/14

摘要： Highly sensitive fluorescent zinc or cadmium sensors are derived from 8-hydroxyquinaldine, a well-established fluorescent zinc probe, as a building block. High binding efficiency was achieved by incorporating two 8-hydroxyquninaldine moieties into a single ligand. Incorporation of sulfonamide groups further improved binding efficiency. The compounds make it possible to monitor zinc ion or cadmium ion concentration in the picomolar or femtomolar range.

摘要翻译： 高灵敏度的荧光锌或镉传感器来自8-羟基喹哪啶，一种成熟的荧光锌探针，作为结构单元。 通过将两个8-羟基喹喔啉部分并入单个配体中来实现高结合效率。 磺酰胺基团的结合进一步提高了结合效率。 这些化合物可以监测皮摩尔或飞摩尔范围内的锌离子或镉离子浓度。

公开(公告)号：US20130267036A1

公开(公告)日：2013-10-10

申请号：US13622248

申请日：2012-09-18

申请人： Joel A. TANG ,  Francesca Gruppi ,  Roman Fleysher ,  Daniel K. Sodickson ,  James W. Canary ,  Alexej Jerschow

发明人： Joel A. TANG ,  Francesca Gruppi ,  Roman Fleysher ,  Daniel K. Sodickson ,  James W. Canary ,  Alexej Jerschow

IPC分类号： G01R33/46 ,  G01N24/08

CPC分类号： G01R33/46 ,  G01N24/08 ,  G01R33/282 ,  Y10T436/24

摘要： A method and system for providing an article of manufacture with increased longevity of hyperpolarized 1H signals (and other species) for NMR spectroscopy and MRI. The method involves providing a material including a molecular species susceptible of NMR spectroscopy, by providing parahydrogen (and other appropriate species) to disperse within the material/solvent to establish increased longevity of the NMR signals. The material can be in a solution with a surfactant and catalysts added to enhance the persistence of parahydrogen (or other species) in the form of enhanced solubility, microbubbles or micelles and resultant hydrogenation (or other species) of the material.

摘要翻译： 一种用于为NMR光谱和MRI提供超极化1H信号（和其他物种）寿命增加的制品的方法和系统。 该方法包括通过提供仲氢（和其它合适的物质）分散在材料/溶剂中以提供核磁共振信号的寿命增加，提供包括易于NMR光谱的分子物质的材料。 该材料可以在添加有表面活性剂和催化剂的溶液中，以增强溶解度，微泡或胶束形式的加氢（或其他物质）形式的仲氢（或其它物质）的持久性。

公开(公告)号：US07024068B2

公开(公告)日：2006-04-04

申请号：US10328126

申请日：2003-12-23

申请人： James W. Canary ,  Suffen Zahn

发明人： James W. Canary ,  Suffen Zahn

IPC分类号： G02B6/26 ,  G02F1/1335 ,  C09K19/34 ,  C07F1/08 ,  C07F3/06

CPC分类号： C07F1/005 ,  B82Y10/00 ,  C09K9/02

摘要： Complexes of organic ligands with a metal ion exhibit unique conformation and spectroscopic properties upon changes in oxidation state of the metal ion. The metal is a redox-active metal ion and may possess additional ligands bonded to it. The organic ligand has three “arms” that are linked together at a central atom; each arm contains atoms that may also coordinate to the metal ion. At least two of the arms possess chromophoric properties. At least one arm contains two different groups that may coordinate to the metal ion. In one oxidation state, a first atom binds to the metal. In a second oxidation state, a second atom binds to the metal. This change in coordination of the metal ion results in a rotation of one of the arms, which changes the orientation of another group, which inverses the orientation of the two chromophoric species with respect to one another.

公开(公告)号：US06541645B1

公开(公告)日：2003-04-01

申请号：US09626167

申请日：2000-07-26

申请人： James W. Canary ,  Steffen Zahn

发明人： James W. Canary ,  Steffen Zahn

IPC分类号： C07F108

CPC分类号： C07F1/005 ,  B82Y10/00 ,  C09K9/02

摘要： Complexes of organic ligands with a metal ion exhibit unique conformation and spectroscopic properties upon changes in oxidation state of the metal ion. The metal is a redox-active metal ion and may possess additional ligands bonded to it. The organic ligand has three “arms” that are linked together at a central atom; each arm contains atoms that may also coordinate to the metal ion. At least two of the arms possess chromophoric properties. At least one arm contains two different groups that may coordinate to the metal ion. In one oxidation state, a first atom binds to the metal. In a second oxidation state, a second atom binds to the metal. This change in coordination of the metal ion results in a rotation of one of the arms, which changes the orientation of another group, which inverses the orientation of the two chromophoric species with respect to one another.

摘要翻译： 有机配体与金属离子的配合物在金属离子的氧化态变化时表现出独特的构象和光谱性质。 金属是氧化还原活性金属离子，并且可以具有与其键合的另外的配体。 有机配体具有在中心原子处连接在一起的三个“臂” 每个臂包含也可以与金属离子配位的原子。 至少两个臂具有发色特性。 至少一个臂包含可以与金属离子配位的两个不同的基团。 在一种氧化态中，第一原子与金属结合。 在第二氧化态中，第二原子与金属结合。 这种金属离子的配位变化导致其中一个臂的旋转，这改变另一组的取向，这反转了两个发色物质相对于彼此的取向。