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公开(公告)号：US20050225328A1
公开(公告)日：2005-10-13
申请号：US11062882
申请日：2005-02-22
申请人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
发明人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
CPC分类号： G01R33/307 , G01N1/44 , G01R33/282 , G01R33/62
摘要： The present invention relates to devices and method for melting solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup 9 in a strong magnetic field in a polarising means 3a, 3b, 3c in a cryostat 2 and then melted inside the cryostat 2 by melting means such as a laser 8 connected by an optical fibre 4 to the interior of the cryostat.
摘要翻译： 本发明涉及在保持高水平偏振的同时熔化固体极化样品的装置和方法。 在本发明的一个实施例中，样品在低温恒温器2中的偏振装置3a，3b，3c中的强磁场中在样品保持杯9中极化，然后通过熔化装置如激光器在低温恒温器2内熔化 8通过光纤4连接到低温恒温器的内部。
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公开(公告)号：US20060192559A1
公开(公告)日：2006-08-31
申请号：US11191140
申请日：2005-07-28
申请人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
发明人： Jan Ardenkjaer-Larsen , Oskar Axelsson , Klaes Golman , Jan Wolber , Mark Howard
IPC分类号： G01V3/00
CPC分类号： G01R33/307 , G01N1/44 , G01R33/282 , G01R33/62
摘要： The present invention relates to devices and methods for melting a solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup in a strong magnetic field in a polarising means in a cryostat and then melted inside the cryostat by melting means such as a laser connected by an optical fibre to the interior of the cryostat.
摘要翻译： 本发明涉及用于熔化固体极化样品同时保持高水平偏振的装置和方法。 在本发明的一个实施例中，样品在低温恒温器中的偏振装置中的强磁场中的样品保持杯中极化，然后通过诸如通过光纤连接到内部的激光器的熔化装置在低温恒温器内熔化 的低温恒温器。
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3.发明授权NMR-based methods for detecting ligands, where the ligand or target are hyperpolarized and the NMR-spectrum is compared with a reference spectrum of the ligand or target 有权用于检测配体的基于NMR的方法，其中配体或靶是超极化的，并且将NMR光谱与配体或靶的参考光谱进行比较公开(公告)号：US07557573B2
公开(公告)日：2009-07-07
申请号：US10537235
申请日：2003-11-27
申请人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham John Cotton , Klaes Golman , Mark Howard , Mathilde H. Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
发明人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham John Cotton , Klaes Golman , Mark Howard , Mathilde H. Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
IPC分类号： G01V3/00
CPC分类号： G01R33/465 , G01N24/08 , G01N24/088 , G01R33/282 , G01R33/62
摘要： The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.
摘要翻译： 本发明涉及包含用于基于NMR的测定中使用的超极化配体或靶的基于NMR的方法。
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4.发明申请Nmr-based methods for detecting ligands, where the ligand or target are hyperpolarized and the nmr-spectrum is compared with a reference spectrum of the ligand or target 有权用于检测配体的基于Nmr的方法，其中配体或靶是超极化的，并且将nmr光谱与配体或靶的参考光谱进行比较公开(公告)号：US20060171891A1
公开(公告)日：2006-08-03
申请号：US10537235
申请日：2003-11-27
申请人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham Cotton , Klaes Golman , Mark Howard , Mathilde Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
发明人： Jan-Henrik Ardenkjaer-Larsen , Herbert Baumann , Graham Cotton , Klaes Golman , Mark Howard , Mathilde Lerche , Rolf Servin , Mikkel Thaning , Jan Wolber
IPC分类号： A61B5/055
CPC分类号： G01R33/465 , G01N24/08 , G01N24/088 , G01R33/282 , G01R33/62
摘要： The invention relates to NMR-based methods comprising hyperpolarised ligands or targets for use in NMR-based assays.
摘要翻译： 本发明涉及包含用于基于NMR的测定中使用的超极化配体或靶的基于NMR的方法。
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5.发明授权Method for investigating the fate of a test compound or the stateof a biological system by means of NMR of hyperpolarised NMR active nuclei 有权通过超极化NMR活性核的NMR研究试验化合物的命运或生物体系的状态的方法公开(公告)号：US08372654B2
公开(公告)日：2013-02-12
申请号：US10311108
申请日：2001-06-12
申请人： Neil Cook , Albie Santos , Nigel Bosworth , Jan Wolber , Mike Looker , Peter Knox , Jan Jenrik Ardenkjaer-Larsen , Klaes Golman
发明人： Neil Cook , Albie Santos , Nigel Bosworth , Jan Wolber , Mike Looker , Peter Knox , Jan Jenrik Ardenkjaer-Larsen , Klaes Golman
IPC分类号： G01N1/00
CPC分类号： G01R33/465 , A61K49/10 , G01N33/5088 , G01R33/5601 , G01R33/62 , Y10T436/24 , Y10T436/25
摘要： The invention is concerned with Nuclear Magnetic Resonance (NMR) spectroscopy and Magnetic Resonance Imaging (MRI), particularly NMR spectroscopy. It provides hyperpolarization methods offering enhanced sensitivity of detection over conventional NMR for studying the fate of a test compound in a biological system. The methods are particularly suitable for studying metabolism and toxicity of drugs. The resulting NMR sensitivity increase is advantageous in two key aspects of NMR detection: test compounds can be detected at lower concentrations and substantial time saving can be achieved in cases where extensive averaging is conventionally employed to increase the signal to noise ratio of the corresponding NMR spectra. The methods can be used for studios that were not practical or not possible using conventional NMR.
摘要翻译： 本发明涉及核磁共振（NMR）光谱和磁共振成像（MRI），特别是NMR光谱。 它提供超极化方法，提供检测与常规NMR的灵敏度，以研究生物系统中测试化合物的命运。 该方法特别适用于研究药物的代谢和毒性。 所得的NMR灵敏度增加在NMR检测的两个关键方面是有利的：可以以较低的浓度检测测试化合物，并且在通常采用广泛平均以提高相应NMR光谱的信噪比的情况下可以实现显着的时间节省 。 该方法可用于使用常规NMR不实用或不可能的工作室。
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6.发明授权Methods and devices for hyperpolarising and melting NMR samples in a cryostat 有权在低温恒温器中超极化和熔解NMR样品的方法和装置公开(公告)号：US07102354B2
公开(公告)日：2006-09-05
申请号：US11062882
申请日：2005-02-22
申请人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Jan Wolber , Mark Howard
发明人： Jan Henrik Ardenkjaer-Larsen , Oskar H. E. Axelsson , Klaes Koppel Golman , Jan Wolber , Mark Howard
CPC分类号： G01R33/307 , G01N1/44 , G01R33/282 , G01R33/62
摘要： The present invention relates to devices and method for melting solid polarised sample while retaining a high level of polarisation. In an embodiment of the present invention a sample is polarised in a sample-retaining cup 9 in a strong magnetic field in a polarising means 3a, 3b, 3c in a cryostat 2 and then melted inside the cryostat 2 by melting means such as a laser 8 connected by an optical fibre 4 to the interior of the cryostat.
摘要翻译： 本发明涉及在保持高水平偏振的同时熔化固体极化样品的装置和方法。 在本发明的一个实施例中，样品在低温恒温器2中的偏振装置3a，3b，3c中的强磁场中在样品保持杯9中极化，然后通过熔化装置熔化在低温恒温器2内 作为通过光纤4连接到低温恒温器内部的激光器8。
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7.发明申请METHODS FOR IN VIVO EVALUATION OF PULMONARY PHYSIOLOGY AND/OR FUNCTION USING NMR SIGNALS OF POLARIZED 129XE 审中-公开使用极化129XE的NMR信号进行血管生成和/或功能的血管生成评估方法公开(公告)号：US20110104067A1
公开(公告)日：2011-05-05
申请号：US12987313
申请日：2011-01-10
申请人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansson , Jan Wolber
发明人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansson , Jan Wolber
IPC分类号： A61B5/055
CPC分类号： A61K49/06 , A61B5/02755 , A61B5/055 , A61B5/0813 , A61B5/411 , A61B5/413 , G01N24/08 , G01R33/46 , G01R33/485 , G01R33/5601 , G01R33/563 , G01R33/56308
摘要： In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.
摘要翻译： 在某些实施方案中，本发明的方法获得在所选结构，环境或系统中的极化129Xe的NMR光谱信号的动态数据集。 信号数据可用于评估：（a）膜或组织的生理学; （b）身体系统或其部分的运行状况或功能（休息时或刺激时）; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。 因此，本发明提供了用于筛选和/或诊断呼吸，心肺病或疾病如慢性心力衰竭的方法和/或用于监测施用于受治疗疾病或疾病的治疗剂的功效的方法。
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公开(公告)号：US07550970B2
公开(公告)日：2009-06-23
申请号：US10553381
申请日：2004-04-13
IPC分类号： G01V3/00
CPC分类号： G01R33/4633 , G01R33/62
摘要： The present invention relates to methods of performing Nuclear Magnetic Resonance (NMR) spectroscopy adapted for a hyperpolarized sample. The methods comprise the steps of hyperpolarizing a sample using DNP, wherein at least a portion of the NMR active nuclei receives hyperpolarization; performing NMR spectroscopy on the sample with the use of sequences of rf-pulses, wherein the pulse sequences comprises at least two rf-pulses, either on the same nuclei or on different nuclei, and wherein the pulse sequence is adapted for a hyperpolarized sample; and analyzing at least two of the NMR spectra to obtain a characterization of the sample, or to obtain an interim result to be used in the NMR spectroscopy step.
摘要翻译： 本发明涉及适用于超极化样品的核磁共振（NMR）光谱的方法。 所述方法包括使用DNP超极化样品的步骤，其中至少一部分NMR活性核接受超极化; 使用rf脉冲序列对样本进行NMR光谱分析，其中所述脉冲序列包括在同一核上或不同核上的至少两个rf脉冲，并且其中所述脉冲序列适用于超极化样品; 并分析至少两个NMR光谱以获得样品的表征，或获得在NMR光谱步骤中使用的中间结果。
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9.发明授权Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized 129Xe 有权使用极化129Xe的NMR信号进行肺生理学和/或功能的体内评估的方法公开(公告)号：US07867477B2
公开(公告)日：2011-01-11
申请号：US11623352
申请日：2007-01-16
申请人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansoon , Jan Wolber
发明人： Bastiaan Driehuys , Margaret Hall , Claudio Marelli , Sven Mansoon , Jan Wolber
IPC分类号： A61B5/055
CPC分类号： A61K49/06 , A61B5/02755 , A61B5/055 , A61B5/0813 , A61B5/411 , A61B5/413 , G01N24/08 , G01R33/46 , G01R33/485 , G01R33/5601 , G01R33/563 , G01R33/56308
摘要： In certain embodiments, methods of the present invention obtain dynamic data sets of an NMR spectroscopy signal of polarized 129Xe in a selected structure, environment, or system. The signal data can be used to evaluate: (a) the physiology of a membrane or tissue; (b) the operational condition or function of a body system or portion thereof (when at rest or under stimulation); and/or (c) the efficacy of a therapeutic treatment used to treat a diagnosed disorder, disease, or condition. Thus, the present invention provides methods for screening and/or diagnosing a respiratory, cardiopulmonary disorder or disease such as chronic heart failure, and/or methods for monitoring the efficacy of therapeutics administered to subject to treat the disorder or disease.
摘要翻译： 在某些实施方案中，本发明的方法获得在所选结构，环境或系统中的极化129Xe的NMR光谱信号的动态数据集。 信号数据可用于评估：（a）膜或组织的生理学; （b）身体系统或其部分的运行状况或功能（休息时或刺激时）; 和/或（c）用于治疗诊断的病症，疾病或病症的治疗性治疗的功效。 因此，本发明提供了用于筛选和/或诊断呼吸，心肺病或疾病如慢性心力衰竭的方法和/或用于监测施用于受治疗疾病或疾病的治疗剂的功效的方法。
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10.发明申请APPARATUS AND METHOD FOR FULLY AUTOMATED CLOSED SYSTEM QUALITY CONTROL OF A SUBSTANCE 有权一种物质完全自动关闭系统质量控制的装置和方法公开(公告)号：US20080275659A1
公开(公告)日：2008-11-06
申请号：US11743288
申请日：2007-05-02
申请人： Peter Miller , Jan Henrik Ardenkjaer-Larsen , Martin John Bradney , Andrew Michael Leach , Per Christian Sontum , Eric John Telfeyan , David Brandon Whitt , Jan Wolber
发明人： Peter Miller , Jan Henrik Ardenkjaer-Larsen , Martin John Bradney , Andrew Michael Leach , Per Christian Sontum , Eric John Telfeyan , David Brandon Whitt , Jan Wolber
IPC分类号： G01N21/01
CPC分类号： G01N21/33 , G01N21/21 , G01N21/35 , G01N21/3577 , G01N2021/8416 , G01R33/282 , G01R33/60
摘要： The present invention provides an apparatus and method for automated quality control of a substance comprising a compartment wherein a substance is located, a monitoring device coupled to the compartment and configured to monitor at least one quality control parameter prior to an end-use of the substance, and a processor coupled to the monitoring device, wherein the monitoring device is configured to communicate data to the processor for comparing at least one quality control parameter to an end-use value, and wherein the processor is further configured to control the release of the substance from the compartment to its end-use.
摘要翻译： 本发明提供了一种用于对物质进行自动质量控制的装置和方法，所述物质包括物质位于其中的隔间，耦合到隔室的监测装置，并且被配置为在物质的最终使用之前监测至少一个质量控制参数 以及耦合到所述监视设备的处理器，其中所述监视设备被配置为将数据传送到所述处理器，用于将至少一个质量控制参数与最终使用值进行比较，并且其中所述处理器还被配置为控制所述处理器的释放 物质从隔间到最终用途。
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