公开(公告)号：US06838086B1

公开(公告)日：2005-01-04

申请号：US09763794

申请日：1999-08-26

申请人： Jan Simon ,  Stefan Martin ,  Christian Termeer

发明人： Jan Simon ,  Stefan Martin ,  Christian Termeer

IPC分类号： A61K39/00 ,  A61K39/39 ,  A61P35/00 ,  C12N5/0784 ,  A01N1/02 ,  A01N65/00 ,  C12N15/63 ,  C12N15/85

CPC分类号： C12N5/0639 ,  A61K39/0011 ,  A61K39/39 ,  A61K2039/55511 ,  C12N2501/22 ,  C12N2501/23 ,  C12N2501/905

摘要： The invention discloses the use of low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, for producing vaccines. The vaccines are particularly suitable for controlling cancer diseases. Surprisingly, it has been found that low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, can be used both for preparing mature dendritic cells and directly, together with antigens or peptides or carrier systems, as an adjuvant in vaccines. It is likewise possible to couple the low molecular weight hyaluronic acid fragments, which can be suitably modified, where appropriate, to an antigen, peptide or carrier system. The coupled system can then be advantageously employed as a vaccine, in particular for treating cancer diseases.

摘要翻译： 本发明公开了使用低分子量透明质酸片段，其可以适当地适当地修饰用于生产疫苗。 疫苗特别适用于控制癌症疾病。 令人惊讶的是，已经发现，适当地可适当地修饰的低分子量透明质酸片段可用于制备成熟树突状细胞，并且可以直接与抗原或肽或载体系统一起用作疫苗中的佐剂。 同样可以将适当地适当修饰的低分子量透明质酸片段连接到抗原，肽或载体系统上。 因此，偶联系统可以有利地用作疫苗，特别是用于治疗癌症疾病。

公开(公告)号：US20050143338A1

公开(公告)日：2005-06-30

申请号：US10487480

申请日：2002-08-21

申请人： Joseph Eisenbarth ,  Stefan Martin ,  Ulrike Wagner-Utermann ,  Michael Eisenhut

发明人： Joseph Eisenbarth ,  Stefan Martin ,  Ulrike Wagner-Utermann ,  Michael Eisenhut

IPC分类号： C07D498/18 ,  C07H19/06 ,  C07H19/00 ,  A61K31/7072

CPC分类号： C07D498/18 ,  C07H19/06 ,  Y02P20/55

摘要： What is described are compounds wherein R represents Br, I or R1—SO3, where R1 is an unsubstituted or substituted C1-C5-alkyl group, or an unsubstituted or substituted phenyl group; X is O or NR″, where R″ is a usual protective group for N; and R′ represents hydrogen, a halogen, such as F, Cl, and Br, a substituted or unsubstituted C1-C7-alkyl group, such as methyl and ethyl, a substituted or unsubstituted C2-C7-alkenyl group, or a substituted or unsubstituted C2-C7-alkynyl group.

摘要翻译： 描述的是其中R表示Br，I或R 1 -SO 3的化合物，其中R 1是未取代或取代的C

公开(公告)号：US06827858B2

公开(公告)日：2004-12-07

申请号：US10275942

申请日：2002-11-14

申请人： Joachim Bader ,  Hans-Heinrich Bechtolsheimer ,  Armin Brucker ,  Toni Dockner ,  Gabriele Iffland ,  Hans Klink ,  Stefan Martin ,  Jürgen Mohr ,  Hans-Martin Mugrauer

发明人： Joachim Bader ,  Hans-Heinrich Bechtolsheimer ,  Armin Brucker ,  Toni Dockner ,  Gabriele Iffland ,  Hans Klink ,  Stefan Martin ,  Jürgen Mohr ,  Hans-Martin Mugrauer

IPC分类号： C02F142

CPC分类号： C08G65/30 ,  B01J39/04 ,  B01J49/06 ,  B01J49/53

摘要： Alkali metal ions are separated off from alkoxylates containing alkali metal ions by a process comprising: a) dilution of the alkali metal-containing alkoxylate with an inert solvent, b) treatment of the alkali metal-containing solution of the alkoxylate with a cationic exchanger in order to obtain a substantially alkali metal-free solution of the alkoxylate, and c) removal of the solvent from the substantially alkali metal-free solution of the alkoxylate in order to obtain a substantially alkali metal-free and substantially solvent-free alkoxylate.

摘要翻译： 碱金属离子与含有碱金属离子的烷氧基离子分离，其方法包括：a）用惰性溶剂稀释含碱金属的烷氧基化物，b）用阳离子交换剂处理含烷氧基化物的碱金属的溶液 以获得基本上不含碱金属的烷氧基化物溶液，和c）从基本上不含碱金属的烷氧基化物溶液中除去溶剂，以获得基本上无碱金属和基本上无溶剂的烷氧基化物。

公开(公告)号：US5595499A

公开(公告)日：1997-01-21

申请号：US634074

申请日：1996-04-17

申请人： Hans-Joachim Zander ,  Dieter Bozzer ,  Stefan Martin

发明人： Hans-Joachim Zander ,  Dieter Bozzer ,  Stefan Martin

IPC分类号： H01R13/639 ,  H01R13/627 ,  H01R13/646 ,  H01R24/40

CPC分类号： H01R24/40 ,  H01R13/6277 ,  H01R2103/00

摘要： A coaxial connector plug includes an inner insulating housing carrying a coaxial connector pin, where an outer grounding spring is positioned coaxially around the housing. The grounding spring is positioned within a sleeve member and a locking spring and outer sleeve are axially moveable between positions where locking arms of the locking spring are moveable to a position where a front edge of the locking arms is engaged with a corresponding surface of the sleeve member. The locking arms also include a locking projection which will reside in a peripheral groove of a mating jack connector when fully inserted thereto.

摘要翻译： 同轴连接器插头包括承载同轴连接器针的内部绝缘壳体，其中外部接地弹簧同轴地位于壳体周围。 接地弹簧定位在套筒构件内，并且锁定弹簧和外套筒可以在锁定弹簧的锁定臂可移动到其中锁定臂的前边缘与套筒的相应表面接合的位置之间轴向移动 会员。 锁定臂还包括锁定突起，该突起将在完全插入其中时位于配合插座连接器的外围槽中。