公开(公告)号：US20110177002A1

公开(公告)日：2011-07-21

申请号：US13054606

申请日：2009-07-14

申请人： Sabine Zitzmann-Kolbe ,  Ulrike Bauder-Wuest ,  Michael Eisenhut ,  Doerte Oltmanns

发明人： Sabine Zitzmann-Kolbe ,  Ulrike Bauder-Wuest ,  Michael Eisenhut ,  Doerte Oltmanns

IPC分类号： A61K49/06 ,  A61K49/00 ,  C12N9/96 ,  A61K31/395 ,  C07K14/00 ,  C07K16/00 ,  C07D255/02 ,  C07D257/02 ,  C07D259/00

CPC分类号： C07D405/12 ,  A61K49/0043 ,  A61K49/0052 ,  A61K51/0482 ,  C07D257/02

摘要： The invention pertains to a compound for detecting cell death. According to the invention, the compound comprises a cyclic polyamine unit for the complexation of a bi- or trivalent metal ion. The compound of the invention may contain a reporting tag like fluorescein or a radioisotope including substituent.

摘要翻译： 本发明涉及用于检测细胞死亡的化合物。 根据本发明，化合物包含用于使二价或三价金属离子络合的环状多胺单元。 本发明的化合物可以含有报告标签如荧光素或包含取代基的放射性同位素。

公开(公告)号：US20050143338A1

公开(公告)日：2005-06-30

申请号：US10487480

申请日：2002-08-21

申请人： Joseph Eisenbarth ,  Stefan Martin ,  Ulrike Wagner-Utermann ,  Michael Eisenhut

发明人： Joseph Eisenbarth ,  Stefan Martin ,  Ulrike Wagner-Utermann ,  Michael Eisenhut

IPC分类号： C07D498/18 ,  C07H19/06 ,  C07H19/00 ,  A61K31/7072

CPC分类号： C07D498/18 ,  C07H19/06 ,  Y02P20/55

摘要： What is described are compounds wherein R represents Br, I or R1—SO3, where R1 is an unsubstituted or substituted C1-C5-alkyl group, or an unsubstituted or substituted phenyl group; X is O or NR″, where R″ is a usual protective group for N; and R′ represents hydrogen, a halogen, such as F, Cl, and Br, a substituted or unsubstituted C1-C7-alkyl group, such as methyl and ethyl, a substituted or unsubstituted C2-C7-alkenyl group, or a substituted or unsubstituted C2-C7-alkynyl group.

摘要翻译： 描述的是其中R表示Br，I或R 1 -SO 3的化合物，其中R 1是未取代或取代的C

公开(公告)号：US20070202047A1

公开(公告)日：2007-08-30

申请号：US11649503

申请日：2007-01-04

申请人： Markus Wolf ,  Ulrike Bauder-Wust ,  Uwe Haberkorn ,  Michael Eisenhut ,  Walter Mier

发明人： Markus Wolf ,  Ulrike Bauder-Wust ,  Uwe Haberkorn ,  Michael Eisenhut ,  Walter Mier

IPC分类号： A61K49/10 ,  C07F5/00 ,  C07D257/02

CPC分类号： C07D257/02 ,  A61K49/103 ,  A61K49/106

摘要： The present invention relates to a polyamine-substituted ligand for the preparation of a contrast agent derived from a chelating molecule selected from the group consisting of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and diethylentriamine-pentaacetic acid (DTPA), wherein at least one of the carboxylic groups of the chelating molecule is reacted with an amine of formula HNR1R2 to form an amide bond, wherein R1, R2 are independently selected from the group consisting of H; (CH2)n—NR3R4; and R5; R3, R4 are independently selected from the group consisting of H; (CH2)m—NR6R7; and (CH2)m-1—CH3; R6, R7 are independently selected from the group consisting of H; and (CH2)o-1—CH3; n, m, o are independently 2, 3, or 4; R5 is of formula and optionally at least one of the carboxylic groups of the chelating molecule is further reacted with a monoalkylamine having 1 to 18 carbon atoms to form an amide bond; provided that at least one of R1, R2 is other than H. Furthermore, the invention relates to contrast agents for magnetic resonance imaging (MRI) comprising said ligands and in-vivo diagnostic methods based on MRI using said contrast agents.

摘要翻译： 本发明涉及用于制备衍生自螯合分子的造影剂的多胺取代配体，所述螯合分子选自1,4,7,10-四氮杂环十二烷-1,4,7,10-四乙酸（DOTA ）和二乙基三胺五乙酸（DTPA），其中螯合分子的至少一个羧基与式HNR 1 R 2的胺反应形成 酰胺键，其中R 1，R 2，R 2独立地选自H; （CH 2）n - NR 3 - 3 - - - - - - - 和R 5; R 3，R 4，R 4独立地选自H; （CH 2 CH 2）m -NR 6 R 6 R 7 R 7， 和（CH 2 CH 2）m-1 -CH 3 3; R 6，R 7，R 7独立地选自H; 和（CH 2）2 -O-1 -CH 3; n，m，o分别为2,3或4; R 5是下式，并且任选地，螯合分子的至少一个羧酸基团与具有1至18个碳原子的单烷基胺进一步反应以形成酰胺键; 条件是R 1，R 2和R 2中的至少一个不是H.此外，本发明涉及用于包含所述配体的磁共振成像（MRI）的造影剂，并且在 - 使用所述造影剂的基于MRI的体内诊断方法。

公开(公告)号：US20090130020A1

公开(公告)日：2009-05-21

申请号：US12208939

申请日：2008-09-11

申请人： Lutz Lehmann ,  Mathias Berndt ,  Dietmar Berndorff ,  Sabine Zitzmann-Kolbe ,  Ulrike Bauder-Wust ,  Martin Schafer ,  Uwe Haberkorn ,  Michael Eisenhut ,  Armin Runz

发明人： Lutz Lehmann ,  Mathias Berndt ,  Dietmar Berndorff ,  Sabine Zitzmann-Kolbe ,  Ulrike Bauder-Wust ,  Martin Schafer ,  Uwe Haberkorn ,  Michael Eisenhut ,  Armin Runz

IPC分类号： A61K51/00 ,  C07D315/00 ,  C07C309/63 ,  A61P35/00 ,  C07D263/08 ,  C07C215/02

CPC分类号： A61K51/0406 ,  A61K51/0421 ,  A61K51/0453

摘要： This invention relates to novel compounds F-18 radio-labeled amino-alcohols suitable for labeling or already labeled by 18F methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds, compositions or kits for diagnostic imaging by positron emission tomography (PET).

摘要翻译： 本发明涉及适用于标记的新化合物F-18放射性标记的氨基醇或已经通过18F制备这种化合物的方法已经标记的组合物，包含这些化合物的组合物，包含这些化合物或组合物的试剂，以及这些化合物，组合物或试剂盒的用途 用于通过正电子发射断层扫描（PET）进行诊断成像。

公开(公告)号：US07145000B2

公开(公告)日：2006-12-05

申请号：US10487480

申请日：2002-08-21

申请人： Joseph Antonius Maria Eisenbarth ,  Stefan Johannes Martin ,  Ulrike Wagner-Utermann ,  Michael Eisenhut

发明人： Joseph Antonius Maria Eisenbarth ,  Stefan Johannes Martin ,  Ulrike Wagner-Utermann ,  Michael Eisenhut

IPC分类号： C07H19/00 ,  C07H19/048 ,  C07H19/06

CPC分类号： C07D498/18 ,  C07H19/06 ,  Y02P20/55

摘要： What is described are compounds wherein R represents Br, I or R1—SO3, where R1 is an unsubstituted or substituted C1–C5-alkyl group, or an unsubstituted or substituted phenyl group; X is O or NR″, where R″ is a usual protective group for N; and R′ represents hydrogen, a halogen, such as F, Cl, and Br, a substituted or unsubstituted C1–C7-alkyl group, such as methyl and ethyl, a substituted or unsubstituted C2–C7-alkenyl group, or a substituted or unsubstituted C2–C7-alkynyl group.

摘要翻译： 描述的是其中R表示Br，I或R 1 -SO 3的化合物，其中R 1是未取代或取代的C

公开(公告)号：US07007260B2

公开(公告)日：2006-02-28

申请号：US10273524

申请日：2002-10-18

申请人： Helge Altfeld ,  Monika Gschöderer ,  Michael Eisenhut ,  Marc Walter ,  Beate Frankowsky

发明人： Helge Altfeld ,  Monika Gschöderer ,  Michael Eisenhut ,  Marc Walter ,  Beate Frankowsky

IPC分类号： G06F17/50

CPC分类号： G06F17/5068 ,  H01L23/528 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method for fabricating an integrated semiconductor circuit having at least two different wiring forms realized in a same metallization plane includes drawing each of the different wiring forms on respectively different layer types. In this manner, the at least two different wiring forms can be individually and jointly analyzed.

公开(公告)号：US06891033B2

公开(公告)日：2005-05-10

申请号：US10470817

申请日：2002-01-28

申请人： Stefan Johannes Martin ,  Joseph Antonius Maria Eisenbarth ,  Ulrike Wagner-Utermann ,  Michael Eisenhut ,  Walter Mier

发明人： Stefan Johannes Martin ,  Joseph Antonius Maria Eisenbarth ,  Ulrike Wagner-Utermann ,  Michael Eisenhut ,  Walter Mier

IPC分类号： C07H19/06 ,  A61K31/7072

CPC分类号： C07H19/06

摘要： The application relates to compounds that are suitable as labelable precursors for synthesis of 3′-[18F]fluoro-3′-deoxythymidine and that have formula (1), in which R denotes triphenylmethyl, triphenylmethyl substituted in the phenyl group, trialkylmethyl, triphenylsilyl, triphenylsilyl substituted in the phenyl group, or trialkylsilyl, R′ denotes R1—SO2, where R1 is an unsubstituted or substituted C1 to C5 alkyl or an unsubstituted or substituted phenyl, and R″ denotes C2 to C10 alkyloxycarbonyl, with the exception of 3-N-Boc-1-(3-O-nosyl-5-O-trityl-2-deoxy-β-D-lyxofuranosy The application also relates to a method for preparation of these compounds and to the use of the same for synthesis of 3′-[18F]fluoro-3′-deoxythymidine.

摘要翻译： 本申请涉及适用于合成3' - [16 F]氟-3'-脱氧胸苷的可标记前体的化合物，其具有式（1），其中R表示三苯基甲基，三苯基甲基取代的 在苯基中，三烷基甲基，三苯基甲硅烷基，苯基取代的三苯基甲硅烷基或三烷基甲硅烷基，R'表示R 1 -SO 2 - ，其中R 1， SUP>是未取代或取代的C 1至C 5烷基或未取代或取代的苯基，R“表示C 2至C 除了3-N-Boc-1-（3-O-壬基-5-O-三苯甲基-2-脱氧-β-D-吡喃葡萄糖醛酸之外），除了3-N-Boc- 1-烷氧基羰基外，本申请还涉及 制备这些化合物的方法及其用于合成3' - [[18 F]氟-3'-脱氧胸苷的方法。