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公开(公告)号:US07314936B2
公开(公告)日:2008-01-01
申请号:US10500840
申请日:2003-01-07
申请人: Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人: Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号: C07D498/02 , C07D513/02 , C07D515/02 , C07D471/02
CPC分类号: A61K31/437 , C07D471/04
摘要: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally
摘要翻译: 本发明提供具有式(I)的化合物,其中R 1,R 2,R 3和n如通常和类别所述 并且另外提供其药物组合物,及其用于治疗炎性或自身免疫性和增殖性疾病的方法,以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂
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公开(公告)号:US20110105427A1
公开(公告)日:2011-05-05
申请号:US12917669
申请日:2010-11-02
申请人: Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人: Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号: A61K31/437 , A61K31/5377 , A61K31/496 , A61K31/541 , A61K31/4545 , A61K31/444 , A61K31/4709 , A61K31/55 , A61K31/439 , A61K31/4725 , A61K31/695 , A61P29/00 , A61P35/00 , A61P37/06 , A61P17/06 , A61P11/06 , A61P9/00
CPC分类号: A61K31/437 , C07D471/04
摘要: The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.
摘要翻译: 本发明提供了具有式(I)的化合物:其中R 1,R 2,R 3和n如本文中一般和本领域和亚类所述,并且另外提供其药物组合物,及其用于治疗炎症或自身免疫的方法 和增殖性疾病以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂。
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公开(公告)号:US07868002B2
公开(公告)日:2011-01-11
申请号:US11906056
申请日:2007-09-28
申请人: Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人: Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号: C07D413/14 , C07D471/02 , A61K31/4745 , A61K31/5377 , A61P11/06 , A61P19/02 , A61P25/00 , A61P3/10 , A61P9/00
CPC分类号: A61K31/437 , C07D471/04
摘要: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds.
摘要翻译: 如上所述,仍然需要开发可用于治疗炎性或自身免疫性和增殖性疾病的新型治疗剂。 本发明提供了通式(I)的新型化合物及其药物组合物,如本文中一般和本课程和亚类所述,以及制备和使用这些化合物的方法。
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公开(公告)号:US08691814B2
公开(公告)日:2014-04-08
申请号:US12917669
申请日:2010-11-02
申请人: Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人: Jane Daun , Heather A. Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , André Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris M. Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号: A61K31/437 , A61K31/496 , A61K31/4545 , A61K31/444 , A61P35/00
CPC分类号: A61K31/437 , C07D471/04
摘要: The present invention provides compounds having formula (I): wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.
摘要翻译: 本发明提供了具有式(I)的化合物:其中R 1,R 2,R 3和n如本文中一般和本领域和亚类所述,并且另外提供其药物组合物,及其用于治疗炎症或自身免疫的方法 和增殖性疾病以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂。
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公开(公告)号:US20080103137A1
公开(公告)日:2008-05-01
申请号:US11906056
申请日:2007-09-28
申请人: Jane Daun , Heather Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , Andre Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人: Jane Daun , Heather Davis , Bruce DeCosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , Andre Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris Seletsky , Motohiro Soejima , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号: A61K31/4745 , A61K31/5377 , A61P11/06 , A61P19/02 , A61P25/00 , A61P3/10 , A61P35/00 , A61P9/00 , C07D413/14 , C07D471/02
CPC分类号: A61K31/437 , C07D471/04
摘要: As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds
摘要翻译: 如上所述,仍然需要开发可用于治疗炎性或自身免疫性和增殖性疾病的新型治疗剂。 本发明提供通式(I)的新化合物及其药物组合物,如本文中一般和本课题和亚类所述,以及制备和使用这些化合物的方法
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公开(公告)号:US20050124649A1
公开(公告)日:2005-06-09
申请号:US10500840
申请日:2003-01-07
申请人: Jane Daun , Heather Davis , Bruce DeAcosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , Andre Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris Seletsky , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
发明人: Jane Daun , Heather Davis , Bruce DeAcosta , Fabian Gusovsky , Ieharu Hishinuma , Yimin Jiang , Toshihiko Kaneko , Kouichi Kikuchi , Seiichi Kobayashi , Andre Lescarbeau , Xiang-Yi Li , Kenzo Muramoto , Norihito Ohi , Marc Pesant , Boris Seletsky , Mark Spyvee , Lynda Tremblay , Ye Yao , Hiromitsu Yokohama , Yan (Janet) Zhao , Wanjun Zheng
IPC分类号: A61K31/437 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/55 , A61P1/04 , A61P3/10 , A61P7/04 , A61P9/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P29/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07D471/04 , C07D519/00 , C07D471/02 , A61K31/4745
CPC分类号: A61K31/437 , C07D471/04
摘要: The present invention provides compounds having formula (I), wherein R1, R2, R3 and n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally.
摘要翻译: 本发明提供具有式(I)的化合物,其中R 1,R 2,R 3和n如通常和类别所述 并且另外提供其药物组合物,以及其用于治疗炎症或自身免疫和增殖性疾病的方法,以及作为细胞粘附分子表达和炎性细胞因子信号转导的抑制剂。
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公开(公告)号:US06518423B1
公开(公告)日:2003-02-11
申请号:US09230852
申请日:1999-04-05
申请人: Toshihiko Kaneko , Richard Clark , Norihito Ohi , Fumihiro Ozaki , Tetsuya Kawahara , Atsushi Kamada , Kazuo Okano , Hiromitsu Yokohama , Kenzo Muramoto , Tohru Arai , Masayoshi Ohkuro , Osamu Takenaka , Jiro Sonoda
发明人: Toshihiko Kaneko , Richard Clark , Norihito Ohi , Fumihiro Ozaki , Tetsuya Kawahara , Atsushi Kamada , Kazuo Okano , Hiromitsu Yokohama , Kenzo Muramoto , Tohru Arai , Masayoshi Ohkuro , Osamu Takenaka , Jiro Sonoda
IPC分类号: C07D51300
CPC分类号: C07D487/04 , C07D513/04
摘要: Benzopiperidine derivatives represented by formula (I), salts thereof or hydrates thereof, processes for producing the same and drugs comprising the same: wherein the variables are as described in the specification. These compounds are useful as drugs efficacious in the prevention and treatment of these various inflammatory diseases and immunologic diseases, such as rheumatoid arthritis, atopic dermatitis, psoriasis, asthma, and rejection reaction accompanying organ transplantation.
摘要翻译: 由式(I)表示的苯并哌啶衍生物,其盐或其水合物,其制备方法和包含其的药物:其中变量如说明书中所述。 这些化合物可用作预防和治疗各种炎性疾病和免疫疾病,如类风湿性关节炎,特应性皮炎,牛皮癣,哮喘和伴随器官移植排斥反应的药物。
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公开(公告)号:US5110956A
公开(公告)日:1992-05-05
申请号:US517444
申请日:1990-04-23
申请人: Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
发明人: Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
IPC分类号: A61K31/335 , C07D317/46 , C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/12 , C07D493/04
CPC分类号: C07D405/12 , C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D413/12 , C07D493/04
摘要: A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
摘要翻译: 提供苯并间二氧杂环戊烯衍生物在苯环中具有取代基,羧基烷基硫代烷基等。 这样的衍生物有效治疗肝脏疾病。 还提供了包含这些衍生物的组合物以及这些衍生物用于制备药物的用途。
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公开(公告)号:US5292901A
公开(公告)日:1994-03-08
申请号:US832220
申请日:1992-02-06
申请人: Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
发明人: Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
IPC分类号: C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/12 , C07D493/04 , A61K31/36
CPC分类号: C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/10 , C07D493/04
摘要: A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
摘要翻译: 新的苯并间二氧杂环戊烯衍生物在苯环中具有取代基,其是羧烷基硫代烷基等,并且有效治疗肝脏疾病。
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公开(公告)号:US5475024A
公开(公告)日:1995-12-12
申请号:US166019
申请日:1993-10-14
申请人: Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
发明人: Yoshitake Ogata , Makoto Ikeda , Seiichiro Nomoto , Makoto Okita , Naoyuki Shimomura , Toshihiko Kaneko , Takashi Yamanaka , Ieharu Hishinuma , Junichi Nagakawa , Kazuo Hirota , Kaname Miyamoto , Toru Horie , Tsuneo Wakabayashi
IPC分类号: C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/12 , C07D493/04 , A61K31/36
CPC分类号: C07D317/50 , C07D317/54 , C07D317/56 , C07D317/60 , C07D317/70 , C07D405/12 , C07D413/10 , C07D493/04
摘要: A new benzodioxole derivative has a substituent in the phenyl ring which is a carboxyalkylthioalkyl or the like and is effective to treat a liver disease.
摘要翻译: 新的苯并间二氧杂环戊烯衍生物在苯环中具有取代基,其是羧烷基硫代烷基等,并且有效治疗肝脏疾病。
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