公开(公告)号：US20200222478A1

公开(公告)日：2020-07-16

申请号：US16737950

申请日：2020-01-09

申请人： Janssen Biotech, Inc.

发明人： Kurtis E. Bachman ,  Vipul Bhargava ,  Darryl L. Davis ,  Vinod Krishna ,  Guido Leoni ,  David Pocalyko ,  Pegah Safabakhsh ,  Manuel Sepulveda ,  Derick Siegel ,  Marco Gottardis

IPC分类号： A61K35/761 ,  A61K39/00 ,  C07K16/30

摘要： The disclosure relates to prostate neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the prostate neoantigens, and methods of making and using them.

公开(公告)号：US11793843B2

公开(公告)日：2023-10-24

申请号：US16737950

申请日：2020-01-09

申请人： Janssen Biotech, Inc.

发明人： Kurtis E. Bachman ,  Vipul Bhargava ,  Darryl L. Davis ,  Vinod Krishna ,  Guido Leoni ,  David Pocalyko ,  Pegah Safabakhsh ,  Manuel Sepulveda ,  Derick Siegel ,  Marco Gottardis

IPC分类号： C07K16/30 ,  A61K35/761 ,  A61K39/00 ,  A61K45/06

CPC分类号： A61K35/761 ,  A61K39/001194 ,  A61K39/001195 ,  C07K16/3069 ,  A61K45/06 ,  A61K2039/51 ,  A61K2039/545 ,  A61K2039/572

摘要： The disclosure relates to prostate neoantigens, polynucleotides encoding them, vectors, host cells, recombinant virus particles, vaccines comprising the neoantigens, proteinaceous molecules binding the prostate neoantigens, and methods of making and using them.

公开(公告)号：US20230285548A1

公开(公告)日：2023-09-14

申请号：US18080639

申请日：2022-12-13

申请人： Janssen Biotech, Inc.

发明人： Patrick WILKINSON ,  Manuel Alejandro Sepulveda ,  Charles George Drake ,  Derick Siegel

IPC分类号： A61K39/235 ,  A61K39/285 ,  A61K39/395 ,  A61K45/06

CPC分类号： A61K39/235 ,  A61K39/285 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505

摘要： Disclosed herein are methods of treating or preventing a myeloproliferative disease, a cancer, or a cardiovascular disease, and methods of inducing an immune response, in a subject having a JAK2V617F substitution and/or a CALR exon 9 mutation.

公开(公告)号：US20230190903A1

公开(公告)日：2023-06-22

申请号：US18080634

申请日：2022-12-13

申请人： Janssen Biotech, Inc.

发明人： Patrick WILKINSON ,  Manuel Alejandro SEPULVEDA ,  Charles George DRAKE ,  Derick Siegel

IPC分类号： A61K39/00 ,  A61K39/395 ,  A61P35/00

CPC分类号： A61K39/001193 ,  A61K39/3955 ,  A61P35/00 ,  A61K2039/5256 ,  A61K2039/70 ,  A61K2039/545

摘要： Disclosed herein are methods of treating or preventing prostate cancer in a subject, the methods comprising administering to the subject a treatment regimen comprising two or more vaccines comprising a great ape adenovirus serotype 20 (GAd20) virus that, in turn, comprises a nucleotide sequence encoding the amino acid sequence of SEQ ID NO: 1 and one or more vaccines comprising a Modified Vaccinia Ankara (MVA) virus that, in turn, comprises a nucleotide sequence encoding the amino acid sequence of SEQ ID NO: 3 to thereby treat or prevent the prostate cancer.