公开(公告)号：US20180170909A1

公开(公告)日：2018-06-21

申请号：US15847999

申请日：2017-12-20

Applicant: Janssen Biotech, Inc.

Inventor： Tianbao Lu ,  Brett Douglas Allison ,  Joseph Kent Barbay ,  Peter J. Connolly ,  Maxwell David Cummings ,  Gaston Diels ,  James Patrick Edwards ,  Kevin D. Kreutter ,  Ulrike Philippar ,  Fang Shen ,  Johannes Wilhelmus John Fitzgerald Thuring ,  Tongfei Wu

IPC: C07D401/14 ,  C07D401/12 ,  A61P35/00 ,  A61P19/02 ,  A61P1/00 ,  A61P11/06 ,  A61P37/00

Abstract: Disclosed are compounds, compositions and methods for treating of diseases, syndromes, conditions, and disorders that are affected by the modulation of MALT1. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5, R6, R5, G1, and G2 are defined herein.

公开(公告)号：US20240158499A1

公开(公告)日：2024-05-16

申请号：US18549665

申请日：2022-03-11

Applicant: JANSSEN BIOTECH, INC.

Inventor： Songmao Zheng ,  John Emery ,  Jennifer F. Nemeth ,  Fang Shen ,  Pankaj Seth

IPC: C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2803 ,  A61K2039/505 ,  C07K2317/565 ,  C07K2317/622

Abstract: The invention provides antigen binding domains that bind Cluster of Differentiation 79B protein (CD79B) protein comprising the antigen binding domains that bind CD79b, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US20200010571A1

公开(公告)日：2020-01-09

申请号：US16567646

申请日：2019-09-11

Applicant: Janssen Biotech, Inc.

Inventor： Mark Chiu ,  Jennifer Nemeth-Seay ,  Tatiana Ort ,  Fang Shen

IPC: C07K16/46 ,  A61K39/395 ,  A61K45/06 ,  C07K16/24

Abstract: The present invention relates to bispecific anti-TNF-α/IL-17A antibodies and anti-TNF-α antibodies, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

公开(公告)号：US20170218092A1

公开(公告)日：2017-08-03

申请号：US15417560

申请日：2017-01-27

Applicant: Janssen Biotech, Inc.

Inventor： Mark Chiu ,  Jennifer Nemeth-Seay ,  Tatiana Ort ,  Fang Shen

IPC: C07K16/46 ,  A61K39/395 ,  A61K45/06 ,  C07K16/24

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61P29/00 ,  A61P37/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to bispecific anti-TNF-α/IL-17A antibodies and anti-TNF-α antibodies, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.