公开(公告)号：US20230322924A1

公开(公告)日：2023-10-12

申请号：US18180225

申请日：2023-03-08

Applicant: Janssen Biotech, Inc.

Inventor： Francois Gaudet ,  Jill Giles-Komar ,  Bradley Heidrich ,  Chichi Huang ,  Colleen Kane ,  Ronan Mcdaid ,  Jennifer Nemeth-Seay

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  C07K16/30

CPC classification number: C07K16/2809 ,  A61P35/00 ,  A61K39/39541 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/3069 ,  A61K2039/505

Abstract: The present invention relates to antibodies that specifically bind CD3. The present invention relates to antibodies that specifically bind PSMA. The present invention relates to antibodies that specifically bind CD3 and PSMA. The invention relates to antibodies that specifically bind IL1RAP. The present invention relates to antibodies that specifically bind CD33. The present invention relates to antibodies that specifically bind CD3 and IL1RAP. The present invention relates to antibodies that specifically bind CD3 and CD33. The present invention relates to antibodies that specifically bind TMEFF2. The present invention relates to antibodies that specifically bind CD3 and TMEFF2. The present invention relates to fragments of the antibodies, polynucleotides encoding the antibodies or fragments thereof, and methods of making and using the same.

公开(公告)号：US11603405B2

公开(公告)日：2023-03-14

申请号：US16418082

申请日：2019-05-21

Applicant: Janssen Biotech, Inc.

Inventor： Francois Gaudet ,  Jill Giles-Komar ,  Bradley Heidrich ,  Chichi Huang ,  Colleen Kane ,  Ronan McDaid ,  Jennifer Nemeth-Seay

IPC: C07K16/28 ,  A61P35/00 ,  A61K39/395 ,  C07K16/30 ,  A61K39/00

Abstract: The present invention relates to antibodies that specifically bind CD3. The present invention relates to antibodies that specifically bind PSMA. The present invention relates to antibodies that specifically bind CD3 and PSMA. The present invention relates to antibodies that specifically bind IL1RAP. The present invention relates to antibodies that specifically bind CD33. The present invention relates to antibodies that specifically bind CD3 and IL1RAP. The present invention relates to antibodies that specifically bind CD3 and CD33. The present invention relates to antibodies that specifically bind TMEFF2. The present invention relates to antibodies that specifically bind CD3 and TMEFF2. The present invention relates to fragments of the antibodies, polynucleotides encoding the antibodies or fragments thereof, and methods of making and using the same.

公开(公告)号：US20160347840A1

公开(公告)日：2016-12-01

申请号：US15148371

申请日：2016-05-06

Applicant: Janssen Biotech, Inc.

Inventor： Glenn Anderson ,  Rosa Cardoso ,  Michael Diem ,  Francois Gaudet ,  Shalom Goldberg ,  Benjamin Harman ,  Linus Hyun ,  Steven Jacobs ,  Donna Klein ,  Yingzhe Li ,  Jinquan Luo ,  Ronan McDaid ,  Jill Mooney ,  Jennifer Nemeth-Seay ,  Karyn O'Neil ,  Steven Pomerantz ,  Galla Chandra Rao ,  Tracy Spinka-Doms ,  Alexey Teplyakov ,  Leopoldo Luistro ,  Sheng-Jiun Wu

IPC: C07K16/28 ,  C07K14/78 ,  A61K45/06 ,  C07K16/30 ,  A61K39/395

CPC classification number: C07K16/2809 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6869 ,  A61K49/0045 ,  A61K49/0058 ,  A61K2039/505 ,  C07K14/78 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2318/20 ,  C07K2319/30 ,  C12Y304/17021

Abstract: Provided herein are isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.

Abstract translation: 本文提供了分离的CD3×PSMA-双特异性抗原结合分子或其双特异性抗原结合片段，其中FN3结构域特异性结合人前列腺特异性膜抗原（PSMA）和第二抗原结合位点免疫特异性结合CD3。 还描述了能够编码所提供的融合蛋白的融合蛋白和相关多核苷酸，以及表达所提供的融合蛋白的细胞。 此外，描述了使用所提供的分离的CD3×PSMA-双特异性抗原结合分子或其双特异性抗原结合片段的方法。

公开(公告)号：US20200010571A1

公开(公告)日：2020-01-09

申请号：US16567646

申请日：2019-09-11

Applicant: Janssen Biotech, Inc.

Inventor： Mark Chiu ,  Jennifer Nemeth-Seay ,  Tatiana Ort ,  Fang Shen

IPC: C07K16/46 ,  A61K39/395 ,  A61K45/06 ,  C07K16/24

Abstract: The present invention relates to bispecific anti-TNF-α/IL-17A antibodies and anti-TNF-α antibodies, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.

公开(公告)号：US20170218092A1

公开(公告)日：2017-08-03

申请号：US15417560

申请日：2017-01-27

Applicant: Janssen Biotech, Inc.

Inventor： Mark Chiu ,  Jennifer Nemeth-Seay ,  Tatiana Ort ,  Fang Shen

IPC: C07K16/46 ,  A61K39/395 ,  A61K45/06 ,  C07K16/24

CPC classification number: C07K16/468 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  A61P29/00 ,  A61P37/00 ,  C07K16/241 ,  C07K16/244 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention relates to bispecific anti-TNF-α/IL-17A antibodies and anti-TNF-α antibodies, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.