公开(公告)号：US20250011454A1

公开(公告)日：2025-01-09

申请号：US18703264

申请日：2022-10-19

Applicant: Janssen Biotech, Inc.

Inventor： Adam ZWOLAK ,  Jason HO ,  James TESTA, Jr. ,  Michael Riis HANSEN ,  Xiefan LIN-SCHMIDT ,  Ian WHITE ,  Sanjaya SINGH

IPC: C07K16/28 ,  C07K16/30

Abstract: Provided herein, in certain aspects, is a binding molecule comprising an antigen binding domain and an Fc region; wherein the antigen binding domain is monovalent and the Fc region comprises K248E and T437R mutations (RE mutations), wherein amino acid residue numbering is according to the EU numbering system; wherein the binding molecule has increased capability of hexamerization on a cell surface, and/or increased capability of engaging C1q.

公开(公告)号：US20220356266A1

公开(公告)日：2022-11-10

申请号：US17233021

申请日：2021-04-16

Applicant: JANSSEN BIOTECH, INC.

Inventor： Rajkumar GANESAN ,  Adam ZWOLAK ,  Jason HO ,  Natasa OBERMAJER ,  Michael DIEM ,  Sanjaya SINGH ,  Sathyadevi VENKATARAMANI ,  Theresa MCDEVITT ,  Fei SHEN

IPC: C07K16/30 ,  C07K16/28

Abstract: A population of antibodies, wherein less than 80% of the oligosaccharides covalently attached to the population of the antibodies via N297 residues thereof comprise a core fucose residue; and wherein the population of the antibodies comprises an antibody which Fc region comprises K338A and T437R mutations, or K248E and T437R mutations.