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公开(公告)号：US20250011454A1
公开(公告)日：2025-01-09
申请号：US18703264
申请日：2022-10-19
Applicant: Janssen Biotech, Inc.
Inventor： Adam ZWOLAK , Jason HO , James TESTA, Jr. , Michael Riis HANSEN , Xiefan LIN-SCHMIDT , Ian WHITE , Sanjaya SINGH
Abstract: Provided herein, in certain aspects, is a binding molecule comprising an antigen binding domain and an Fc region; wherein the antigen binding domain is monovalent and the Fc region comprises K248E and T437R mutations (RE mutations), wherein amino acid residue numbering is according to the EU numbering system; wherein the binding molecule has increased capability of hexamerization on a cell surface, and/or increased capability of engaging C1q.
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公开(公告)号：US20220089737A1
公开(公告)日：2022-03-24
申请号：US17472237
申请日：2021-09-10
Applicant: JANSSEN BIOTECH, INC.
Inventor： Rajkumar GANESAN , Michael Riis HANSEN , Iqbal S. GREWAL , Sanjaya SINGH
Abstract: Provided herein are trispecific antibodies or antigen binding fragments thereof that bind to Vβ17, CD28 and another target (e.g., a cancer antigen, such as BCMA or PSMA) are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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公开(公告)号：US20250043004A1
公开(公告)日：2025-02-06
申请号：US18912192
申请日：2024-10-10
Applicant: JANSSEN BIOTECH, INC.
Inventor： Rajkumar GANESAN , Michael Riis HANSEN , Iqbal S. GREWAL , Sanjaya SINGH
Abstract: Provided herein are trispecific antibodies or antigen binding fragments thereof that bind to Vβ17, CD28 and another target (e.g., a cancer antigen, such as BCMA or PSMA) are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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Patent Agency Ranking
公开(公告)号：US20220089736A1
公开(公告)日：2022-03-24
申请号：US17472186
申请日：2021-09-10
Applicant: JANSSEN BIOTECH, INC.
Inventor： Iqbal S. GREWAL , Michael Riis HANSEN , Rajkumar GANESAN , Sanjaya SINGH
IPC: C07K16/28
Abstract: Provided herein, in certain aspects, are antibodies that bind to CD28, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Also provided herein, in certain aspects, are multispecific antibodies that bind to CD28, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Methods of making and using the antibodies are also provided.
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公开(公告)号：US20250092134A1
公开(公告)日：2025-03-20
申请号：US18706417
申请日：2022-11-01
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , IqbaI S. GREWAL , Sanjaya SINGH , Michael Riis HANSEN
IPC: C07K16/28
Abstract: Anti-Vβ17 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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公开(公告)号：US20220125947A1
公开(公告)日：2022-04-28
申请号：US17512195
申请日：2021-10-27
Applicant: JANSSEN BIOTECH, INC.
Inventor： Rajkumar GANESAN , Iqbal S. GREWAL , Sanjaya SINGH , Michael Riis HANSEN
Abstract: Provided herein, in certain aspects, are antibodies that bind to T cell receptor (TCR) Vγ9 (TRGV9), TCR Vδ2 (TRDV2), or the TCR gamma/delta constant region (TRGDC), as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Methods of making and using the antibodies are also provided.
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公开(公告)号：US20220112288A1
公开(公告)日：2022-04-14
申请号：US17499597
申请日：2021-10-12
Applicant: JANSSEN BIOTECH, INC.
Inventor： Rajkumar GANESAN , Sanjaya SINGH , Iqbal S. GREWAL , Michael Riis HANSEN
Abstract: Provided herein, in certain aspects, are antibodies that bind to CD8, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Also provided herein, in certain aspects, are antibodies that bind to CD4, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Also provided herein, in certain aspects, are multispecific antibodies that bind to CD4 and CD8, as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Methods of making the antibodies are also provided.
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公开(公告)号：US20220089731A1
公开(公告)日：2022-03-24
申请号：US17472198
申请日：2021-09-10
Applicant: JANSSEN BIOTECH, INC.
Inventor： Rajkumar GANESAN , Iqbal S. GREWAL , Sanjaya SINGH , Michael Riis HANSEN
IPC: C07K16/28 , C07K16/30 , C12N5/0783 , A61P35/00
Abstract: Anti-Vβ17 antibodies or antigen binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies, and methods of using the antibodies for treating or preventing diseases.
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