公开(公告)号：US20240067754A1

公开(公告)日：2024-02-29

申请号：US18461191

申请日：2023-09-05

Applicant: Janssen Biotech, Inc.

Inventor： Jinquan LUO ,  Lauren BOUCHER ,  Michael FELDKAMP ,  Michael DIEM ,  Anthony A. ARMSTRONG ,  Alexey TEPLYAKOV ,  Chichi HUANG

IPC: C07K16/42 ,  C07K14/705 ,  C07K16/00

CPC classification number: C07K16/4283 ,  C07K14/705 ,  C07K16/00 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/624 ,  C07K2317/94

Abstract: Disclosed are materials and methods for improved single chain variable fragments.

公开(公告)号：US20190127444A1

公开(公告)日：2019-05-02

申请号：US15579860

申请日：2016-06-04

Applicant: NEW YORK UNIVERSITY ,  JANSSEN BIOTECH, INC.

Inventor： Randall J. BREZSKI ,  Anthony S. LYNCH ,  Peter T. BUCKLEY ,  Jeffrey FERNANDEZ ,  Jinquan LUO ,  Thomas J. MALIA ,  Sheng-Jiun WU ,  Victor J. TORRES

IPC: C07K14/78 ,  C07K16/12 ,  G01N33/569

Abstract: The present disclosure is directed to staphylococcal leukotoxin and hemolysin binding molecules and fusion constructs. The present disclosure is further directed to methods of treating, preventing, and diagnosing staphylococcal infection in a subject using the binding molecules and fusion constructs described herein.

公开(公告)号：US20220064254A1

公开(公告)日：2022-03-03

申请号：US16936719

申请日：2020-07-23

Applicant: Janssen Biotech, Inc.

Inventor： Raymond BRITTINGHAM ,  Rajkumar GANESAN ,  Sherry LA PORTE ,  John T. LEE ,  Jinquan LUO ,  Theresa MCDEVITT ,  Fei SHEN ,  Sanjaya SINGH ,  Degang SONG ,  Sathyadevi VENKATARAMANI ,  Fang YI ,  Yonghong ZHAO

IPC: C07K14/725 ,  A61K35/17 ,  C07K16/40 ,  C07K14/705

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

公开(公告)号：US20170210799A1

公开(公告)日：2017-07-27

申请号：US15409630

申请日：2017-01-19

Applicant: JANSSEN BIOTECH, INC.

Inventor： Glenn Mark ANDERSON ,  Eric T. BALDWIN ,  Benjamin HARMAN ,  Rosa M.F. CARDOSO ,  Jennifer F. NEMETH-SEAY ,  Ricardo ATTAR ,  Francois GAUDET ,  Yingzhe LI ,  Jinquan LUO ,  Ronan MCDAID ,  Steven C. POMERANTZ ,  Susan H. TAM ,  Alexey TEPLYAKOV ,  Sheng-Jiun WU

IPC: C07K16/28

CPC classification number: C07K16/28 ,  A61K2039/505 ,  C07K16/2803 ,  C07K16/2809 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92

Abstract: Provided herein are isolated antibodies that immunospecifically bind to ROR1, bispecific antibodies comprising an antigen-binding site that immunospecifically binds to ROR1 and an antigen-binding site that immunospecifically binds to CD3, and methods of using the same.