公开(公告)号：US20250145711A1

公开(公告)日：2025-05-08

申请号：US18830184

申请日：2024-09-10

Applicant: Janssen Biotech, Inc.

Inventor： Adam Zwolak ,  Raymond Brittingham ,  Scott R. Brodeur ,  Rajkumar Ganesan ,  Sherry Lynn La Porte ,  Jinquan Luo ,  Fang Yi ,  Colleen M. Kane ,  Triveni K. Bhatt

IPC: C07K16/28 ,  A61K39/00 ,  C07K16/46 ,  C12N15/85

Abstract: The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3ε, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US20230265218A1

公开(公告)日：2023-08-24

申请号：US18172987

申请日：2023-02-22

Applicant: Xencor, Inc. ,  Janssen Biotech, Inc.

Inventor： John R. Desjarlais ,  Gregory Moore ,  Michael Hedvat ,  Juan Diaz ,  Veronica Gusti Zeng ,  Matthew Adam Dragovich ,  Joseph Erhardt ,  Theresa McDevitt ,  Fouad Moussa ,  Pankaj Seth ,  Fei Shen ,  Adam Zwolak

IPC: C07K16/46

CPC classification number: C07K16/468 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/622

Abstract: Provided herein are novel anti-CD28×anti-PSMA antibodies and methods of using such antibodies for the treatment of PSMA-associated cancers. Subject anti-CD28×anti-PSMA antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and PSMA on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3×anti-PSMA antibodies) for the treatment of prostate cancers.

公开(公告)号：US20250122299A1

公开(公告)日：2025-04-17

申请号：US18818199

申请日：2024-08-28

Applicant: Xencor, Inc. ,  Janssen Biotech, Inc.

Inventor： Gregory L. Moore ,  Michael Hedvat ,  Matthew Adam Dragovich ,  Lorena Fontan Gabas ,  Adam Zwolak ,  Ulrike Philippar ,  Pankaj Seth ,  Nele Vloemans ,  Ivo Cornelissen

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00

Abstract: Provided herein are novel anti-CD20 x anti-CD28 antibodies and methods of using such antibodies for the treatment of B-cell malignancies. Subject anti-CD20 x anti-CD28 antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and CD20 on tumor cells. Thus, such antibodies enhance anti-tumor activity at tumor sites. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3 x anti-CD20 x anti-CD79b antibodies) for the treatment of B-cell malignancies.

公开(公告)号：US11952411B2

公开(公告)日：2024-04-09

申请号：US17405872

申请日：2021-08-18

Applicant: JANSSEN BIOTECH, INC.

Inventor： Adam Zwolak ,  Szeman Chan ,  Rajkumar Ganesan

IPC: C07K14/705 ,  A61K38/00 ,  A61P37/04 ,  C07K14/765

CPC classification number: C07K14/70575 ,  A61P37/04 ,  C07K14/765 ,  A61K38/00 ,  C07K2319/30 ,  C07K2319/31 ,  C07K2319/74

Abstract: Described herein are compositions and kits that comprise an engineered TL1A ligand that displays high stability, minimal binding to decoy receptor DcR3 while retaining functional activity via binding to its cell surface receptor, DR3, and the ability to activate T cells in vitro and in vivo. Methods of making an engineered TL1A ligand and methods of treating a disease or disorder in a subject by administering an engineered TL1A ligand are also provided.

公开(公告)号：US20220411504A1

公开(公告)日：2022-12-29

申请号：US17330462

申请日：2021-05-26

Applicant: Janssen Biotech, Inc.

Inventor： Raymond Brittingham ,  Scott R. Brodeur ,  Rajkumar Ganesan ,  Jaclyn Hoover ,  Steven A. Jacobs ,  Colleen M. Kane ,  Jinquan Luo ,  Sanjaya Singh ,  Fang Yi ,  Adam Zwolak ,  Triveni K. Bhatt ,  Michael Dennis Feldkamp ,  Sherry Lynn La Porte

IPC: C07K16/28 ,  A61P35/00 ,  C07K16/30 ,  C07K16/42

Abstract: The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3ε, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US12084501B2

公开(公告)日：2024-09-10

申请号：US17701764

申请日：2022-03-23

Applicant: Janssen Biotech, Inc.

Inventor： Adam Zwolak ,  Raymond Brittingham ,  Scott R. Brodeur ,  Rajkumar Ganesan ,  Sherry Lynn La Porte ,  Jinquan Luo ,  Fang Yi ,  Colleen M. Kane ,  Triveni K. Bhatt

IPC: C07K16/28 ,  C07K16/46 ,  C12N15/85 ,  A61K39/00

CPC classification number: C07K16/2809 ,  C07K16/468 ,  C12N15/85 ,  A61K2039/507 ,  C07K2317/31 ,  C07K2317/55 ,  C07K2317/622

Abstract: The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3ε, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US20240218082A1

公开(公告)日：2024-07-04

申请号：US18440860

申请日：2024-02-13

Applicant: Xencor, Inc. ,  Janssen Biotech, Inc.

Inventor： John R. Desjarlais ,  Gregory Moore ,  Michael Hedvat ,  Juan Diaz ,  Veronica Gusti Zeng ,  Matthew Adam Dragovich ,  Joseph Erhardt ,  Theresa McDevitt ,  Fouad Moussa ,  Pankaj Seth ,  Fei Shen ,  Adam Zwolak

IPC: C07K16/46 ,  C07K16/28 ,  C07K16/30

CPC classification number: C07K16/468 ,  C07K16/2818 ,  C07K16/3069 ,  C07K2317/31 ,  C07K2317/565 ,  C07K2317/622

Abstract: Provided herein are novel anti-CD28 x anti-PSMA antibodies and methods of using such antibodies for the treatment of PSMA-associated cancers. Subject anti-CD28 x anti-PSMA antibodies are capable of agonistically binding to CD28 costimulatory molecules on T cells and PSMA on tumor cells. Thus, such antibodies selectively enhance anti-tumor activity at tumor sites while minimizing peripheral toxicity. The subject antibodies provided herein are particularly useful in combination with other anti-cancer therapies (e.g., anti-CD3 x anti-PSMA antibodies) for the treatment of prostate cancers.

公开(公告)号：US20230040715A1

公开(公告)日：2023-02-09

申请号：US17701764

申请日：2022-03-23

Applicant: Janssen Biotech, Inc.

Inventor： Adam Zwolak ,  Raymond Brittingham ,  Scott R. Brodeur ,  Rajkumar Ganesan ,  Sherry Lynn La Porte ,  Jinquan Luo ,  Fang Yi ,  Colleen M. Kane ,  Triveni K. Bhatt

IPC: C07K16/28 ,  C07K16/46 ,  C12N15/85

Abstract: The disclosure provides antigen binding domains that bind cluster of differentiation 3 (CD3) protein, comprising the antigen binding domains that bind CD3ε, polynucleotides encoding them, vectors, host cells, methods of making and using them.

公开(公告)号：US11149094B2

公开(公告)日：2021-10-19

申请号：US15997222

申请日：2018-06-04

Applicant: Janssen Biotech, Inc.

Inventor： Mark Chiu ,  Adam Zwolak

IPC: C07K16/46 ,  C07K16/24 ,  C07K16/10 ,  C07K16/28

Abstract: The present invention relates to engineered multispecific antibodies and other multimeric proteins with asymmetrical CH2-CH3 region mutations and methods of making and using them.

公开(公告)号：US20180346605A1

公开(公告)日：2018-12-06

申请号：US15997222

申请日：2018-06-04

Applicant: Janssen Biotech, Inc.

Inventor： Mark Chiu ,  Adam Zwolak

IPC: C07K16/46

Abstract: The present invention relates to engineered multispecific antibodies and other multimeric proteins with asymmetrical CH2-CH3 region mutations and methods of making and using them.