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公开(公告)号：US11732019B2
公开(公告)日：2023-08-22
申请号：US17168325
申请日：2021-02-05
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Mark J. Wall , Yue-Mei Zhang
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
CPC分类号： C07K14/575 , A61K9/0019 , A61K38/17 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/68 , A61K47/6811 , A61K47/6845 , A61K47/6883 , A61K49/0032 , A61K49/0052 , A61K49/0056 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , C07K1/061 , C07K1/1072 , C07K1/12 , C07K1/18 , C07K5/0205 , C07K14/57545 , C07K16/00 , C07K16/24 , A61K38/00 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要： The present invention comprises compounds of Formula I.
wherein:
Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.-
公开(公告)号：US10961293B2
公开(公告)日：2021-03-30
申请号：US16344141
申请日：2017-10-26
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Mark J. Wall , Yue-Mei Zhang
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
摘要： The present invention comprises compounds of Formula I. wherein: Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.
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公开(公告)号：US10858413B2
公开(公告)日：2020-12-08
申请号：US16344263
申请日：2017-10-26
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Mark J. Wall , Yue-Mei Zhang , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Ellen Chi
IPC分类号： C07K14/575 , A61K47/68 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , C07K16/24 , A61K9/00 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
摘要： The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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公开(公告)号：US11591379B2
公开(公告)日：2023-02-28
申请号：US16820174
申请日：2020-03-16
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Yue-Mei Zhang , Mark J. Wall , Ellen Chi
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K38/17 , A61K38/26 , A61K47/64 , A61P3/10 , A61K47/60 , A61P3/08 , A61P3/04 , A61P3/06 , A61K38/22 , A61K9/00 , C07K1/06 , C07K1/107 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61P3/00 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
摘要： The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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公开(公告)号：US20180127476A1
公开(公告)日：2018-05-10
申请号：US15794231
申请日：2017-10-26
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Yue-Mei Zhang , Mark Wall
摘要： The present invention comprises compounds of Formula I. wherein: Z4, Z7, Z9, Z11, Z22, Z23, Z26, Z30, Z34, Z35, p, m, n, q, and BRIDGE are defined in the specification. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel compounds are useful for preventing, treating or ameliorating diseases and disorders, such as obesity, type 2 diabetes, the metabolic syndrome, insulin resistance, and dyslipidemia, among others.
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公开(公告)号：US10787495B2
公开(公告)日：2020-09-29
申请号：US16542751
申请日：2019-08-16
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Yue-Mei Zhang , Mark J. Wall , Ellen Chi
IPC分类号： A61K47/00 , A61K47/60 , C07K16/00 , A61K39/00 , A61K39/395 , A61K38/12 , A61K38/26 , C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , A61K38/00
摘要： The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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公开(公告)号：US11767354B2
公开(公告)日：2023-09-26
申请号：US17168503
申请日：2021-02-05
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Yue-Mei Zhang , Mark J. Wall , Ellen Chi
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
CPC分类号： C07K14/575 , A61K9/0019 , A61K38/17 , A61K38/1709 , A61K38/22 , A61K38/26 , A61K45/06 , A61K47/60 , A61K47/64 , A61K47/68 , A61K47/6811 , A61K47/6845 , A61K47/6883 , A61K49/0032 , A61K49/0052 , A61K49/0056 , A61P3/00 , A61P3/04 , A61P3/06 , A61P3/08 , A61P3/10 , C07K1/061 , C07K1/1072 , C07K1/12 , C07K1/18 , C07K5/0205 , C07K14/57545 , C07K16/00 , C07K16/24 , A61K38/00 , A61K2039/505 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/71 , C07K2317/92 , C07K2317/94 , C07K2319/30
摘要： The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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公开(公告)号：US10968265B2
公开(公告)日：2021-04-06
申请号：US16344174
申请日：2017-10-26
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Yue-Mei Zhang , Mark J. Wall , Ellen Chi
IPC分类号： C07K14/575 , A61K47/68 , C07K16/24 , A61K9/00 , A61K38/17 , A61K38/26 , C07K1/06 , C07K1/107 , A61K47/64 , A61P3/10 , A61K49/00 , C07K1/12 , C07K1/18 , C07K5/02 , A61K47/60 , A61P3/08 , A61P3/00 , A61P3/04 , A61P3/06 , A61K38/22 , A61K45/06 , C07K16/00 , A61K38/00 , A61K39/00
摘要： The present invention comprises conjugates comprising a monoclonal antibody conjugated to a cyclic PYY peptide. The invention also relates to pharmaceutical compositions and methods for use thereof. The novel conjugates are useful for preventing, treating or ameliorating diseases and disorders disclosed herein.
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公开(公告)号：US20180125998A1
公开(公告)日：2018-05-10
申请号：US15794250
申请日：2017-10-26
发明人： Mark Macielag , Raymond J. Patch , Rui Zhang , Martin A. Case , Shamina M. Rangwala , James N. Leonard , Raul C. Camacho , Michael J. Hunter , Katharine E. D'Aquino , Wilson Edwards , Ronald V. Swanson , Wenying Jian , Yue-Mei Zhang , Mark Wall , Ellen Chi
摘要： The present invention relates to a monoclonal antibody platform designed to be coupled to therapeutic peptides to increase the half-life of the therapeutic peptide in a subject. The invention also relates to pharmaceutical compositions and methods for use thereof.
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